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2. p16INK4a downregulation is involved in immortalization of primary human prostate epithelial cells induced by telomerase. Shao G; Balajee AS; Hei TK; Zhao Y Mol Carcinog; 2008 Oct; 47(10):775-83. PubMed ID: 18383581 [TBL] [Abstract][Full Text] [Related]
3. Genetic and epigenetic changes in human epithelial cells immortalized by telomerase. Farwell DG; Shera KA; Koop JI; Bonnet GA; Matthews CP; Reuther GW; Coltrera MD; McDougall JK; Klingelhutz AJ Am J Pathol; 2000 May; 156(5):1537-47. PubMed ID: 10793065 [TBL] [Abstract][Full Text] [Related]
4. Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations. Garbe JC; Vrba L; Sputova K; Fuchs L; Novak P; Brothman AR; Jackson M; Chin K; LaBarge MA; Watts G; Futscher BW; Stampfer MR Cell Cycle; 2014; 13(21):3423-35. PubMed ID: 25485586 [TBL] [Abstract][Full Text] [Related]
5. p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells. Jarrard DF; Sarkar S; Shi Y; Yeager TR; Magrane G; Kinoshita H; Nassif N; Meisner L; Newton MA; Waldman FM; Reznikoff CA Cancer Res; 1999 Jun; 59(12):2957-64. PubMed ID: 10383161 [TBL] [Abstract][Full Text] [Related]
6. Events in the immortalizing process of primary human mammary epithelial cells by the catalytic subunit of human telomerase. Kim H; Farris J; Christman SA; Kong BW; Foster LK; O'Grady SM; Foster DN Biochem J; 2002 Aug; 365(Pt 3):765-72. PubMed ID: 11978176 [TBL] [Abstract][Full Text] [Related]
7. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Dickson MA; Hahn WC; Ino Y; Ronfard V; Wu JY; Weinberg RA; Louis DN; Li FP; Rheinwald JG Mol Cell Biol; 2000 Feb; 20(4):1436-47. PubMed ID: 10648628 [TBL] [Abstract][Full Text] [Related]
8. Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells. Darbro BW; Lee KM; Nguyen NK; Domann FE; Klingelhutz AJ Oncogene; 2006 Nov; 25(56):7421-33. PubMed ID: 16767161 [TBL] [Abstract][Full Text] [Related]
9. Breast primary epithelial cells that escape p16-dependent stasis enter a telomere-driven crisis state. Feijoo P; Terradas M; Soler D; Domínguez D; Tusell L; Genescà A Breast Cancer Res; 2016 Jan; 18(1):7. PubMed ID: 26758019 [TBL] [Abstract][Full Text] [Related]
10. Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells. Schwarze SR; Shi Y; Fu VX; Watson PA; Jarrard DF Oncogene; 2001 Dec; 20(57):8184-92. PubMed ID: 11781834 [TBL] [Abstract][Full Text] [Related]
11. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Rheinwald JG; Hahn WC; Ramsey MR; Wu JY; Guo Z; Tsao H; De Luca M; Catricalà C; O'Toole KM Mol Cell Biol; 2002 Jul; 22(14):5157-72. PubMed ID: 12077343 [TBL] [Abstract][Full Text] [Related]
12. Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation. Harada H; Nakagawa H; Oyama K; Takaoka M; Andl CD; Jacobmeier B; von Werder A; Enders GH; Opitz OG; Rustgi AK Mol Cancer Res; 2003 Aug; 1(10):729-38. PubMed ID: 12939398 [TBL] [Abstract][Full Text] [Related]
13. Association of p16(INK4a) and pRb inactivation with immortalization of human cells. Tsutsui T; Kumakura S; Yamamoto A; Kanai H; Tamura Y; Kato T; Anpo M; Tahara H; Barrett JC Carcinogenesis; 2002 Dec; 23(12):2111-7. PubMed ID: 12507935 [TBL] [Abstract][Full Text] [Related]
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15. Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT. Haga K; Ohno S; Yugawa T; Narisawa-Saito M; Fujita M; Sakamoto M; Galloway DA; Kiyono T Cancer Sci; 2007 Feb; 98(2):147-54. PubMed ID: 17233832 [TBL] [Abstract][Full Text] [Related]
16. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Kiyono T; Foster SA; Koop JI; McDougall JK; Galloway DA; Klingelhutz AJ Nature; 1998 Nov; 396(6706):84-8. PubMed ID: 9817205 [TBL] [Abstract][Full Text] [Related]
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19. Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells. Yang G; Rosen DG; Mercado-Uribe I; Colacino JA; Mills GB; Bast RC; Zhou C; Liu J Carcinogenesis; 2007 Jan; 28(1):174-82. PubMed ID: 16829690 [TBL] [Abstract][Full Text] [Related]
20. Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells. Ramirez RD; Herbert BS; Vaughan MB; Zou Y; Gandia K; Morales CP; Wright WE; Shay JW Oncogene; 2003 Jan; 22(3):433-44. PubMed ID: 12545164 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]