These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

291 related articles for article (PubMed ID: 27863425)

  • 1. Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells.
    Castagnola P; Bellese G; Birocchi F; Gagliani MC; Tacchetti C; Cortese K
    Oncotarget; 2016 Dec; 7(51):85411-85429. PubMed ID: 27863425
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination.
    Marx C; Held JM; Gibson BW; Benz CC
    Cancer Res; 2010 May; 70(9):3709-17. PubMed ID: 20406983
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments.
    Cortese K; Howes MT; Lundmark R; Tagliatti E; Bagnato P; Petrelli A; Bono M; McMahon HT; Parton RG; Tacchetti C
    Mol Biol Cell; 2013 Jan; 24(2):129-44. PubMed ID: 23154999
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer.
    Zhang J; Liu S; Li Q; Shi Y; Wu Y; Liu F; Wang S; Zaky MY; Yousuf W; Sun Q; Guo D; Wang T; Zhang Y; Wang Y; Li M; Liu H
    Cell Death Differ; 2020 Sep; 27(9):2710-2725. PubMed ID: 32327714
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Protein kinase C mediated internalization of ErbB2 is independent of clathrin, ubiquitination and Hsp90 dissociation.
    Dietrich M; Malik MS; Nikolaysen F; Skeie M; Stang E
    Exp Cell Res; 2018 Oct; 371(1):139-150. PubMed ID: 30098331
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Clathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cells.
    Barr DJ; Ostermeyer-Fay AG; Matundan RA; Brown DA
    J Cell Sci; 2008 Oct; 121(Pt 19):3155-66. PubMed ID: 18765569
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
    Lerdrup M; Hommelgaard AM; Grandal M; van Deurs B
    J Cell Sci; 2006 Jan; 119(Pt 1):85-95. PubMed ID: 16352662
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK).
    Qing G; Yan P; Xiao G
    Cell Res; 2006 Nov; 16(11):895-901. PubMed ID: 17088896
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.
    Xu W; Yuan X; Jung YJ; Yang Y; Basso A; Rosen N; Chung EJ; Trepel J; Neckers L
    Cancer Res; 2003 Nov; 63(22):7777-84. PubMed ID: 14633703
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Endocytic down-regulation of ErbB2 is stimulated by cleavage of its C-terminus.
    Lerdrup M; Bruun S; Grandal MV; Roepstorff K; Kristensen MM; Hommelgaard AM; van Deurs B
    Mol Biol Cell; 2007 Sep; 18(9):3656-66. PubMed ID: 17626164
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.
    Krishnamoorthy GP; Guida T; Alfano L; Avilla E; Santoro M; Carlomagno F; Melillo RM
    J Biol Chem; 2013 Jun; 288(24):17481-94. PubMed ID: 23629654
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent.
    Pedersen NM; Madshus IH; Haslekås C; Stang E
    Mol Cancer Res; 2008 Mar; 6(3):491-500. PubMed ID: 18337455
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Geldanamycin destabilizes HER2 tyrosine kinase and suppresses Wnt/beta-catenin signaling in HER2 overexpressing human breast cancer cells.
    Wang K; Ma Q; Ren Y; He J; Zhang Y; Zhang Y; Chen W
    Oncol Rep; 2007 Jan; 17(1):89-96. PubMed ID: 17143483
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Flotillin depletion affects ErbB protein levels in different human breast cancer cells.
    Asp N; Pust S; Sandvig K
    Biochim Biophys Acta; 2014 Sep; 1843(9):1987-96. PubMed ID: 24747692
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2.
    Pedersen NM; Breen K; Rødland MS; Haslekås C; Stang E; Madshus IH
    Mol Cancer Res; 2009 Feb; 7(2):275-84. PubMed ID: 19208749
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Phosphorylation accelerates geldanamycin-induced Akt degradation.
    Su CH; Lan KH; Li CP; Chao Y; Lin HC; Lee SD; Lee WP
    Arch Biochem Biophys; 2013 Aug; 536(1):6-11. PubMed ID: 23668972
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.
    Khaledian B; Taguchi A; Shin-Ya K; Kondo-Ida L; Kagaya N; Suzuki M; Kajino T; Yamaguchi T; Shimada Y; Takahashi T
    Cancer Sci; 2021 Mar; 112(3):1225-1234. PubMed ID: 33370472
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Neratinib induces ErbB2 ubiquitylation and endocytic degradation via HSP90 dissociation in breast cancer cells.
    Zhang Y; Zhang J; Liu C; Du S; Feng L; Luan X; Zhang Y; Shi Y; Wang T; Wu Y; Cheng W; Meng S; Li M; Liu H
    Cancer Lett; 2016 Nov; 382(2):176-185. PubMed ID: 27597738
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Preubiquitinated chimeric ErbB2 is constitutively endocytosed and subsequently degraded in lysosomes.
    Vuong TT; Berger C; Bertelsen V; Rødland MS; Stang E; Madshus IH
    Exp Cell Res; 2013 Feb; 319(3):32-45. PubMed ID: 23127513
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade.
    Mimnaugh EG; Xu W; Vos M; Yuan X; Neckers L
    Mol Cancer Res; 2006 Sep; 4(9):667-81. PubMed ID: 16966435
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.