380 related articles for article (PubMed ID: 27914802)
1. Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors.
Lee JH; Shin SC; Seo SH; Seo YH; Jeong N; Kim CW; Kim EE; Keum G
Bioorg Med Chem Lett; 2017 Jan; 27(2):237-241. PubMed ID: 27914802
[TBL] [Abstract][Full Text] [Related]
2. Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line.
Jung MH; Kim H; Choi WK; El-Gamal MI; Park JH; Yoo KH; Sim TB; Lee SH; Baek D; Hah JM; Cho JH; Oh CH
Bioorg Med Chem Lett; 2009 Dec; 19(23):6538-43. PubMed ID: 19857963
[TBL] [Abstract][Full Text] [Related]
3. Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study.
Lee JH; El-Damasy AK; Seo SH; Gadhe CG; Pae AN; Jeong N; Hong SS; Keum G
Bioorg Med Chem; 2018 Nov; 26(21):5596-5611. PubMed ID: 30385226
[TBL] [Abstract][Full Text] [Related]
4. Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase.
Xing R; Zhang H; Yuan J; Zhang K; Li L; Guo H; Zhao L; Zhang C; Li S; Gao T; Liu Y; Wang L
Eur J Med Chem; 2017 Oct; 139():531-541. PubMed ID: 28830032
[TBL] [Abstract][Full Text] [Related]
5. Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening.
Sun HP; Jia JM; Jiang F; Xu XL; Liu F; Guo XK; Cherfaoui B; Huang HZ; Pan Y; You QD
Eur J Med Chem; 2014 May; 79():399-412. PubMed ID: 24763261
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents.
Tian C; Wang M; Han Z; Fang F; Zhang Z; Wang X; Liu J
Eur J Med Chem; 2017 Sep; 138():630-643. PubMed ID: 28711701
[TBL] [Abstract][Full Text] [Related]
7. Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents.
Gao T; Zhang C; Shi X; Guo R; Zhang K; Gu J; Li L; Li S; Zheng Q; Cui M; Cui M; Gao X; Liu Y; Wang L
Eur J Med Chem; 2019 Sep; 178():329-340. PubMed ID: 31200235
[TBL] [Abstract][Full Text] [Related]
8. Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors.
Suda A; Koyano H; Hayase T; Hada K; Kawasaki K; Komiyama S; Hasegawa K; Fukami TA; Sato S; Miura T; Ono N; Yamazaki T; Saitoh R; Shimma N; Shiratori Y; Tsukuda T
Bioorg Med Chem Lett; 2012 Jan; 22(2):1136-41. PubMed ID: 22192591
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis, and biological evaluation of 2,6,7-substituted pyrrolo[2,3-d]pyrimidines as cyclin dependent kinase inhibitor in pancreatic cancer cells.
Shi X; Quan Y; Wang Y; Wang Y; Li Y
Bioorg Med Chem Lett; 2021 Feb; 33():127725. PubMed ID: 33316409
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, and molecular docking studies of novel pyrazolyl 2-aminopyrimidine derivatives as HSP90 inhibitors.
Mettu A; Talla V; Bajaj DM; Subhashini NJP
Arch Pharm (Weinheim); 2019 Oct; 352(10):e1900063. PubMed ID: 31411362
[TBL] [Abstract][Full Text] [Related]
11. Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone.
Kung PP; Sinnema PJ; Richardson P; Hickey MJ; Gajiwala KS; Wang F; Huang B; McClellan G; Wang J; Maegley K; Bergqvist S; Mehta PP; Kania R
Bioorg Med Chem Lett; 2011 Jun; 21(12):3557-62. PubMed ID: 21612924
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis.
Liu Y; Zhang C; Zhang H; Li M; Yuan J; Zhang Y; Zhou J; Guo H; Zhao L; Du Y; Wang L; Ren L
Eur J Med Chem; 2015 Mar; 93():142-55. PubMed ID: 25668494
[TBL] [Abstract][Full Text] [Related]
13. Discovery of novel pyrrolo-pyridine/pyrimidine derivatives bearing pyridazinone moiety as c-Met kinase inhibitors.
Wang LX; Liu X; Xu S; Tang Q; Duan Y; Xiao Z; Zhi J; Jiang L; Zheng P; Zhu W
Eur J Med Chem; 2017 Dec; 141():538-551. PubMed ID: 29107421
[TBL] [Abstract][Full Text] [Related]
14. 2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance.
Gangjee A; Namjoshi OA; Keller SN; Smith CD
Bioorg Med Chem; 2011 Jul; 19(14):4355-65. PubMed ID: 21680190
[TBL] [Abstract][Full Text] [Related]
15. Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors.
Liang C; Wu X; Li Z; Zhu J; Lu C; Shen Y
Eur J Med Chem; 2018 Jan; 143():85-96. PubMed ID: 29172085
[TBL] [Abstract][Full Text] [Related]
16. Novel water-soluble substituted pyrrolo[3,2-d]pyrimidines: design, synthesis, and biological evaluation as antitubulin antitumor agents.
Gangjee A; Pavana RK; Li W; Hamel E; Westbrook C; Mooberry SL
Pharm Res; 2012 Nov; 29(11):3033-9. PubMed ID: 22814902
[TBL] [Abstract][Full Text] [Related]
17. Cytotoxic and Apoptotic Effects of Novel Pyrrolo[2,3-d]Pyrimidine Derivatives Containing Urea Moieties on Cancer Cell Lines.
Kilic-Kurt Z; Bakar-Ates F; Karakas B; Kütük Ö
Anticancer Agents Med Chem; 2018; 18(9):1303-1312. PubMed ID: 29866023
[TBL] [Abstract][Full Text] [Related]
18. Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-
Cawrse BM; Robinson NM; Lee NC; Wilson GM; Seley-Radtke KL
Molecules; 2019 Jul; 24(14):. PubMed ID: 31340431
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and antiproliferative activity of 2,4-disubstituted 6-aryl-7H-pyrrolo[3,2-d]pyrimidin-7-one 5-oxides.
Pudziuvelyte E; Ríos-Luci C; León LG; Cikotiene I; Padrón JM
Bioorg Med Chem; 2009 Jul; 17(14):4955-60. PubMed ID: 19527934
[TBL] [Abstract][Full Text] [Related]
20. The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: a new class of Aurora-A kinase inhibitors.
Moriarty KJ; Koblish HK; Garrabrant T; Maisuria J; Khalil E; Ali F; Petrounia IP; Crysler CS; Maroney AC; Johnson DL; Galemmo RA
Bioorg Med Chem Lett; 2006 Nov; 16(22):5778-83. PubMed ID: 16949284
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
