119 related articles for article (PubMed ID: 27933890)
1. Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors.
Yoon S; Kim JH; Kim SE; Kim C; Tran PT; Ann J; Koh Y; Jang J; Kim S; Moon HS; Kim WK; Lee S; Lee J; Kim S; Lee J
J Med Chem; 2016 Nov; 59(22):10322-10328. PubMed ID: 27933890
[TBL] [Abstract][Full Text] [Related]
2. Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Yoon S; Zuo D; Kim JH; Yoon I; Ann J; Kim SE; Cho D; Kim WK; Lee S; Lee J; Kim S; Lee J
Bioorg Med Chem; 2018 Aug; 26(14):4073-4079. PubMed ID: 30041947
[TBL] [Abstract][Full Text] [Related]
3. Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).
Yoon S; Kim SE; Kim JH; Yoon I; Tran PT; Ann J; Kim C; Byun WS; Lee S; Kim S; Lee J; Lee J
Bioorg Med Chem; 2019 Mar; 27(6):1099-1109. PubMed ID: 30755350
[TBL] [Abstract][Full Text] [Related]
4. Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Yoon S; Kim JH; Koh Y; Tran PT; Ann J; Yoon I; Jang J; Kim WK; Lee S; Lee J; Kim S; Lee J
Bioorg Med Chem; 2017 Aug; 25(15):4145-4152. PubMed ID: 28625715
[TBL] [Abstract][Full Text] [Related]
5. Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor.
Yoon S; Kim JH; Yoon I; Kim C; Kim SE; Koh Y; Jeong SJ; Lee J; Kim S; Lee J
Bioorg Med Chem Lett; 2016 Jul; 26(13):3038-3041. PubMed ID: 27209231
[TBL] [Abstract][Full Text] [Related]
6. Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.
Kim JH; Lee C; Lee M; Wang H; Kim K; Park SJ; Yoon I; Jang J; Zhao H; Kim HK; Kwon NH; Jeong SJ; Yoo HC; Kim JH; Yang JS; Lee MY; Lee CW; Yun J; Oh SJ; Kang JS; Martinis SA; Hwang KY; Guo M; Han G; Han JM; Kim S
Nat Commun; 2017 Sep; 8(1):732. PubMed ID: 28963468
[TBL] [Abstract][Full Text] [Related]
7. Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction.
Kim JH; Jung K; Lee C; Song D; Kim K; Yoo HC; Park SJ; Kang JS; Lee KR; Kim S; Han JM; Han G
Bioorg Chem; 2021 Jul; 112():104907. PubMed ID: 33979735
[TBL] [Abstract][Full Text] [Related]
8. Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane.
Choi H; Son JB; Kang J; Kwon J; Kim JH; Jung M; Kim SK; Kim S; Mun JY
Biochem Biophys Res Commun; 2017 Nov; 493(2):1129-1135. PubMed ID: 28882589
[TBL] [Abstract][Full Text] [Related]
9. Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway.
Lee M; Kim JH; Yoon I; Lee C; Fallahi Sichani M; Kang JS; Kang J; Guo M; Lee KY; Han G; Kim S; Han JM
Proc Natl Acad Sci U S A; 2018 Jun; 115(23):E5279-E5288. PubMed ID: 29784813
[TBL] [Abstract][Full Text] [Related]
10. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.
Han JM; Jeong SJ; Park MC; Kim G; Kwon NH; Kim HK; Ha SH; Ryu SH; Kim S
Cell; 2012 Apr; 149(2):410-24. PubMed ID: 22424946
[TBL] [Abstract][Full Text] [Related]
11. Leucyl-tRNA synthetase: double duty in amino acid sensing.
Durán RV; Hall MN
Cell Res; 2012 Aug; 22(8):1207-9. PubMed ID: 22525334
[TBL] [Abstract][Full Text] [Related]
12. Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors.
Faes S; Duval AP; Planche A; Uldry E; Santoro T; Pythoud C; Stehle JC; Horlbeck J; Letovanec I; Riggi N; Demartines N; Dormond O
Mol Cancer; 2016 Dec; 15(1):78. PubMed ID: 27919264
[TBL] [Abstract][Full Text] [Related]
13. mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress.
Li J; Shin S; Sun Y; Yoon SO; Li C; Zhang E; Yu J; Zhang J; Blenis J
Cancer Res; 2016 Aug; 76(16):4816-27. PubMed ID: 27197195
[TBL] [Abstract][Full Text] [Related]
14. Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling.
Yoon MS; Son K; Arauz E; Han JM; Kim S; Chen J
Cell Rep; 2016 Aug; 16(6):1510-1517. PubMed ID: 27477288
[TBL] [Abstract][Full Text] [Related]
15. Benzofuran derivatives as anticancer inhibitors of mTOR signaling.
Salomé C; Ribeiro N; Chavagnan T; Thuaud F; Serova M; de Gramont A; Faivre S; Raymond E; Désaubry L
Eur J Med Chem; 2014 Jun; 81():181-91. PubMed ID: 24836070
[TBL] [Abstract][Full Text] [Related]
16. mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo.
Zhang Y; Xu S; Lin J; Yao G; Han Z; Liang B; Zou Z; Chen Z; Song Q; Dai Y; Gao T; Liu A; Bai X
Breast Cancer Res Treat; 2012 Nov; 136(2):379-88. PubMed ID: 23053656
[TBL] [Abstract][Full Text] [Related]
17. Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling.
Nagamori S; Wiriyasermkul P; Okuda S; Kojima N; Hari Y; Kiyonaka S; Mori Y; Tominaga H; Ohgaki R; Kanai Y
Amino Acids; 2016 Apr; 48(4):1045-1058. PubMed ID: 26724922
[TBL] [Abstract][Full Text] [Related]
18. Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation.
Ma C; Cao J; Liang X; Huang Y; Wu P; Li Y; Xu W; Zhang Y
Eur J Med Chem; 2016 Jan; 108():21-27. PubMed ID: 26629857
[TBL] [Abstract][Full Text] [Related]
19. Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.
Teo T; Yu M; Yang Y; Gillam T; Lam F; Sykes MJ; Wang S
Cancer Lett; 2015 Feb; 357(2):612-23. PubMed ID: 25527453
[TBL] [Abstract][Full Text] [Related]
20. The anti-hepatocellular carcinoma cell activity by a novel mTOR kinase inhibitor CZ415.
Zhang W; Chen B; Zhang Y; Li K; Hao K; Jiang L; Wang Y; Mou X; Xu X; Wang Z
Biochem Biophys Res Commun; 2017 Jun; 487(3):494-499. PubMed ID: 28366631
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
