141 related articles for article (PubMed ID: 27943678)
1. Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells.
Moriwaki T; Okamoto S; Sasanuma H; Nagasawa H; Takeda S; Masunaga SI; Tano K
Chem Res Toxicol; 2017 Feb; 30(2):699-704. PubMed ID: 27943678
[TBL] [Abstract][Full Text] [Related]
2. Metabolism of tirapazamine by multiple reductases in the nucleus.
Delahoussaye YM; Evans JW; Brown JM
Biochem Pharmacol; 2001 Nov; 62(9):1201-9. PubMed ID: 11705453
[TBL] [Abstract][Full Text] [Related]
3. Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity.
Elwell JH; Siim BG; Evans JW; Brown JM
Biochem Pharmacol; 1997 Jul; 54(2):249-57. PubMed ID: 9271329
[TBL] [Abstract][Full Text] [Related]
4. Tirapazamine: a hypoxia-activated topoisomerase II poison.
Peters KB; Brown JM
Cancer Res; 2002 Sep; 62(18):5248-53. PubMed ID: 12234992
[TBL] [Abstract][Full Text] [Related]
5. DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2).
Chowdhury G; Junnotula V; Daniels JS; Greenberg MM; Gates KS
J Am Chem Soc; 2007 Oct; 129(42):12870-7. PubMed ID: 17900117
[TBL] [Abstract][Full Text] [Related]
6. Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317.
Siim BG; Pruijn FB; Sturman JR; Hogg A; Hay MP; Brown JM; Wilson WR
Cancer Res; 2004 Jan; 64(2):736-42. PubMed ID: 14744792
[TBL] [Abstract][Full Text] [Related]
7. Enhanced conversion of DNA radical damage to double strand breaks by 1,2,4-benzotriazine 1,4-dioxides linked to a DNA binder compared to tirapazamine.
Anderson RF; Harris TA; Hay MP; Denny WA
Chem Res Toxicol; 2003 Nov; 16(11):1477-83. PubMed ID: 14615975
[TBL] [Abstract][Full Text] [Related]
8. Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells.
Evans JW; Chernikova SB; Kachnic LA; Banath JP; Sordet O; Delahoussaye YM; Treszezamsky A; Chon BH; Feng Z; Gu Y; Wilson WR; Pommier Y; Olive PL; Powell SN; Brown JM
Cancer Res; 2008 Jan; 68(1):257-65. PubMed ID: 18172318
[TBL] [Abstract][Full Text] [Related]
9. Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.
Junnotula V; Sarkar U; Sinha S; Gates KS
J Am Chem Soc; 2009 Jan; 131(3):1015-24. PubMed ID: 19117394
[TBL] [Abstract][Full Text] [Related]
10. Photodynamic Therapy with Liposomal Zinc Phthalocyanine and Tirapazamine Increases Tumor Cell Death via DNA Damage.
Broekgaarden M; Weijer R; van Wijk AC; Cox RC; Egmond MR; Hoebe R; van Gulik TM; Heger M
J Biomed Nanotechnol; 2017 Feb; 13(2):204-20. PubMed ID: 29377650
[TBL] [Abstract][Full Text] [Related]
11. DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine.
Dorie MJ; Kovacs MS; Gabalski EC; Adam M; Le QT; Bloch DA; Pinto HA; Terris DJ; Brown JM
Neoplasia; 1999 Nov; 1(5):461-7. PubMed ID: 10933062
[TBL] [Abstract][Full Text] [Related]
12. Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity.
Guise CP; Abbattista MR; Anderson RF; Li D; Taghipouran R; Tsai A; Lee SJ; Smaill JB; Denny WA; Hay MP; Wilson WR; Hicks KO; Patterson AV
Molecules; 2020 Oct; 25(21):. PubMed ID: 33105798
[TBL] [Abstract][Full Text] [Related]
13. Putative electron-affinic radiosensitizers and markers of hypoxic tissue: Synthesis and preliminary in vitro biological characterization of C3-amino-substituted benzotriazine dioxides (BTDOs).
Elsaidi HR; Yang XH; Ahmadi F; Weinfeld M; Wiebe LI; Kumar P
Eur J Med Chem; 2019 Mar; 165():216-224. PubMed ID: 30684798
[TBL] [Abstract][Full Text] [Related]
14. Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting.
Delahoussaye YM; Hay MP; Pruijn FB; Denny WA; Brown JM
Biochem Pharmacol; 2003 Jun; 65(11):1807-15. PubMed ID: 12781332
[TBL] [Abstract][Full Text] [Related]
15. Photochemical and photobiological studies of tirapazamine (SR 4233) and related quinoxaline 1,4-Di-N-oxide analogues.
Inbaraj JJ; Motten AG; Chignell CF
Chem Res Toxicol; 2003 Feb; 16(2):164-70. PubMed ID: 12588187
[TBL] [Abstract][Full Text] [Related]
16. Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: comparison with other hypoxia-activated prodrugs.
Hunter FW; Wang J; Patel R; Hsu HL; Hickey AJ; Hay MP; Wilson WR
Biochem Pharmacol; 2012 Mar; 83(5):574-85. PubMed ID: 22182429
[TBL] [Abstract][Full Text] [Related]
17. Distinct DNA Damage Spectra Induced by Ionizing Radiation in Normoxic and Hypoxic Cells.
Shimizu N; Ooka M; Takagi T; Takeda S; Hirota K
Radiat Res; 2015 Oct; 184(4):442-8. PubMed ID: 26430822
[TBL] [Abstract][Full Text] [Related]
18. Mitochondrial dysfunction after aerobic exposure to the hypoxic cytotoxin tirapazamine.
Wouters BG; Delahoussaye YM; Evans JW; Birrell GW; Dorie MJ; Wang J; MacDermed D; Chiu RK; Brown JM
Cancer Res; 2001 Jan; 61(1):145-52. PubMed ID: 11196153
[TBL] [Abstract][Full Text] [Related]
19. Carbonic anhydrase 9 (CA9) expression in tumor cells enhances sensitivity to tirapazamine.
Shin HJ; Kim JY; Yoo CW; Roberts SA; Lee S; Choi SJ; Lee HY; Lee DH; Kim TH; Cho KH
J Cancer Res Clin Oncol; 2008 Mar; 134(3):397-404. PubMed ID: 17724612
[TBL] [Abstract][Full Text] [Related]
20. Large-scale analysis of genes that alter sensitivity to the anticancer drug tirapazamine in Saccharomyces cerevisiae.
Hellauer K; Lesage G; Sdicu AM; Turcotte B
Mol Pharmacol; 2005 Nov; 68(5):1365-75. PubMed ID: 16061773
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]