BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

243 related articles for article (PubMed ID: 27951490)

  • 1. 2,4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies.
    Mohamed T; Rao PPN
    Eur J Med Chem; 2017 Jan; 126():823-843. PubMed ID: 27951490
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.
    Osman W; Mohamed T; Sit VM; Vasefi MS; Beazely MA; Rao PP
    Chem Biol Drug Des; 2016 Nov; 88(5):710-723. PubMed ID: 27282589
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease.
    Li Y; Qiang X; Li Y; Yang X; Luo L; Xiao G; Cao Z; Tan Z; Deng Y
    Bioorg Med Chem Lett; 2016 Apr; 26(8):2035-9. PubMed ID: 26947607
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.
    Huang L; Miao H; Sun Y; Meng F; Li X
    Eur J Med Chem; 2014 Nov; 87():429-39. PubMed ID: 25282266
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.
    Manral A; Saini V; Meena P; Tiwari M
    Bioorg Med Chem; 2015 Oct; 23(19):6389-403. PubMed ID: 26337018
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.
    Ma F; Du H
    Eur J Med Chem; 2017 Nov; 140():118-127. PubMed ID: 28923380
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity.
    Su T; Xie S; Wei H; Yan J; Huang L; Li X
    Bioorg Med Chem; 2013 Sep; 21(18):5830-40. PubMed ID: 23932451
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.
    Lan JS; Zhang T; Liu Y; Yang J; Xie SS; Liu J; Miao ZY; Ding Y
    Eur J Med Chem; 2017 Jun; 133():184-196. PubMed ID: 28388521
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of Novel Pyrazolopyrimidinone Derivatives as Phosphodiesterase 9A Inhibitors Capable of Inhibiting Butyrylcholinesterase for Treatment of Alzheimer's Disease.
    Yu YF; Huang YD; Zhang C; Wu XN; Zhou Q; Wu D; Wu Y; Luo HB
    ACS Chem Neurosci; 2017 Nov; 8(11):2522-2534. PubMed ID: 28783948
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives.
    Chakravarty H; Ju Y; Chen WH; Tam KY
    Drug Dev Res; 2020 Apr; 81(2):242-255. PubMed ID: 31837041
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.
    Kumar J; Meena P; Singh A; Jameel E; Maqbool M; Mobashir M; Shandilya A; Tiwari M; Hoda N; Jayaram B
    Eur J Med Chem; 2016 Aug; 119():260-77. PubMed ID: 27227482
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.
    Wichur T; Więckowska A; Więckowski K; Godyń J; Jończyk J; Valdivieso ÁDR; Panek D; Pasieka A; Sabaté R; Knez D; Gobec S; Malawska B
    Eur J Med Chem; 2020 Feb; 187():111916. PubMed ID: 31812794
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel tetrahydroacridine derivatives with iodobenzoic acid moiety as multifunctional acetylcholinesterase inhibitors.
    Skibiński R; Czarnecka K; Girek M; Bilichowski I; Chufarova N; Mikiciuk-Olasik E; Szymański P
    Chem Biol Drug Des; 2018 Feb; 91(2):505-518. PubMed ID: 28944565
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.
    Mohamed T; Yeung JC; Rao PP
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5881-7. PubMed ID: 21873056
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors.
    Mohamed T; Zhao X; Habib LK; Yang J; Rao PP
    Bioorg Med Chem; 2011 Apr; 19(7):2269-81. PubMed ID: 21429752
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.
    Guzior N; Bajda M; Skrok M; Kurpiewska K; Lewiński K; Brus B; Pišlar A; Kos J; Gobec S; Malawska B
    Eur J Med Chem; 2015 Mar; 92():738-49. PubMed ID: 25621991
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents.
    Luo W; Wang T; Hong C; Yang YC; Chen Y; Cen J; Xie SQ; Wang CJ
    Eur J Med Chem; 2016 Oct; 122():17-26. PubMed ID: 27343850
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Lan JS; Xie SS; Li SY; Pan LF; Wang XB; Kong LY
    Bioorg Med Chem; 2014 Nov; 22(21):6089-104. PubMed ID: 25282654
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
    He Y; Yao PF; Chen SB; Huang ZH; Huang SL; Tan JH; Li D; Gu LQ; Huang ZS
    Eur J Med Chem; 2013 May; 63():299-312. PubMed ID: 23501115
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Chromone-lipoic acid conjugate: Neuroprotective agent having acceptable butyrylcholinesterase inhibition, antioxidant and copper-chelation activities.
    Jalili-Baleh L; Nadri H; Forootanfar H; Küçükkılınç TT; Ayazgök B; Sharifzadeh M; Rahimifard M; Baeeri M; Abdollahi M; Foroumadi A; Khoobi M
    Daru; 2021 Jun; 29(1):23-38. PubMed ID: 33420969
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.