156 related articles for article (PubMed ID: 27958734)
1. Novel Irreversible Agonists Acting at the A
Jörg M; Glukhova A; Abdul-Ridha A; Vecchio EA; Nguyen AT; Sexton PM; White PJ; May LT; Christopoulos A; Scammells PJ
J Med Chem; 2016 Dec; 59(24):11182-11194. PubMed ID: 27958734
[TBL] [Abstract][Full Text] [Related]
2. Design and in Vivo Characterization of A
Tosh DK; Rao H; Bitant A; Salmaso V; Mannes P; Lieberman DI; Vaughan KL; Mattison JA; Rothwell AC; Auchampach JA; Ciancetta A; Liu N; Cui Z; Gao ZG; Reitman ML; Gavrilova O; Jacobson KA
J Med Chem; 2019 Feb; 62(3):1502-1522. PubMed ID: 30605331
[TBL] [Abstract][Full Text] [Related]
3. Design and pharmacological profile of a novel covalent partial agonist for the adenosine A
Yang X; Dilweg MA; Osemwengie D; Burggraaff L; van der Es D; Heitman LH; IJzerman AP
Biochem Pharmacol; 2020 Oct; 180():114144. PubMed ID: 32653590
[TBL] [Abstract][Full Text] [Related]
4. Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A
Petrelli R; Scortichini M; Belardo C; Boccella S; Luongo L; Capone F; Kachler S; Vita P; Del Bello F; Maione S; Lavecchia A; Klotz KN; Cappellacci L
J Med Chem; 2018 Jan; 61(1):305-318. PubMed ID: 29257884
[TBL] [Abstract][Full Text] [Related]
5. Quantification of adenosine A(1) receptor biased agonism: Implications for drug discovery.
Baltos JA; Gregory KJ; White PJ; Sexton PM; Christopoulos A; May LT
Biochem Pharmacol; 2016 Jan; 99():101-12. PubMed ID: 26581123
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N(6)-substituents as adenosine A(1) receptor agonists.
Gosling JI; Baker SP; Haynes JM; Kassiou M; Pouton CW; Warfe L; White PJ; Scammells PJ
ChemMedChem; 2012 Jul; 7(7):1191-201. PubMed ID: 22684887
[TBL] [Abstract][Full Text] [Related]
7. 5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists.
Petrelli R; Torquati I; Kachler S; Luongo L; Maione S; Franchetti P; Grifantini M; Novellino E; Lavecchia A; Klotz KN; Cappellacci L
J Med Chem; 2015 Mar; 58(5):2560-6. PubMed ID: 25699637
[TBL] [Abstract][Full Text] [Related]
8. 4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A
Cosimelli B; Greco G; Laneri S; Novellino E; Sacchi A; Trincavelli ML; Giacomelli C; Taliani S; Da Settimo F; Martini C
Chem Biol Drug Des; 2016 Nov; 88(5):724-729. PubMed ID: 27282729
[TBL] [Abstract][Full Text] [Related]
9. Capadenoson, a clinically trialed partial adenosine A
Baltos JA; Vecchio EA; Harris MA; Qin CX; Ritchie RH; Christopoulos A; White PJ; May LT
Biochem Pharmacol; 2017 Jul; 135():79-89. PubMed ID: 28344125
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study.
Romagnoli R; Baraldi PG; Lopez-Cara C; Cruz-Lopez O; Moorman AR; Massink A; IJzerman AP; Vincenzi F; Borea PA; Varani K
Eur J Med Chem; 2015 Aug; 101():185-204. PubMed ID: 26141910
[TBL] [Abstract][Full Text] [Related]
11. Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy.
Nguyen AT; Baltos JA; Thomas T; Nguyen TD; Muñoz LL; Gregory KJ; White PJ; Sexton PM; Christopoulos A; May LT
Mol Pharmacol; 2016 Dec; 90(6):703-714. PubMed ID: 27683014
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor.
Valant C; Aurelio L; Devine SM; Ashton TD; White JM; Sexton PM; Christopoulos A; Scammells PJ
J Med Chem; 2012 Mar; 55(5):2367-75. PubMed ID: 22315963
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene.
Romagnoli R; Baraldi PG; IJzerman AP; Massink A; Cruz-Lopez O; Lopez-Cara LC; Saponaro G; Preti D; Aghazadeh Tabrizi M; Baraldi S; Moorman AR; Vincenzi F; Borea PA; Varani K
J Med Chem; 2014 Sep; 57(18):7673-86. PubMed ID: 25181013
[TBL] [Abstract][Full Text] [Related]
14. Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists.
Louvel J; Guo D; Soethoudt M; Mocking TA; Lenselink EB; Mulder-Krieger T; Heitman LH; IJzerman AP
Eur J Med Chem; 2015 Aug; 101():681-91. PubMed ID: 26210506
[TBL] [Abstract][Full Text] [Related]
15. A Structure-Activity Relationship Study of Bitopic N
Aurelio L; Baltos JA; Ford L; Nguyen ATN; Jörg M; Devine SM; Valant C; White PJ; Christopoulos A; May LT; Scammells PJ
J Med Chem; 2018 Mar; 61(5):2087-2103. PubMed ID: 29446948
[TBL] [Abstract][Full Text] [Related]
16. Current status of A1 adenosine receptor allosteric enhancers.
Romagnoli R; Baraldi PG; Moorman AR; Borea PA; Varani K
Future Med Chem; 2015; 7(10):1247-59. PubMed ID: 26144263
[TBL] [Abstract][Full Text] [Related]
17. Modulation of insulin release by adenosine A1 receptor agonists and antagonists in INS-1 cells: the possible contribution of 86Rb+ efflux and 45Ca2+ uptake.
Töpfer M; Burbiel CE; Müller CE; Knittel J; Verspohl EJ
Cell Biochem Funct; 2008 Dec; 26(8):833-43. PubMed ID: 18979526
[TBL] [Abstract][Full Text] [Related]
18. Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A
Miao Y; Bhattarai A; Nguyen ATN; Christopoulos A; May LT
Sci Rep; 2018 Nov; 8(1):16836. PubMed ID: 30442899
[TBL] [Abstract][Full Text] [Related]
19. 2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists.
Ferguson GN; Valant C; Horne J; Figler H; Flynn BL; Linden J; Chalmers DK; Sexton PM; Christopoulos A; Scammells PJ
J Med Chem; 2008 Oct; 51(19):6165-72. PubMed ID: 18771255
[TBL] [Abstract][Full Text] [Related]
20. Exploring the Role of N
Petrelli R; Scortichini M; Kachler S; Boccella S; Cerchia C; Torquati I; Del Bello F; Salvemini D; Novellino E; Luongo L; Maione S; Jacobson KA; Lavecchia A; Klotz KN; Cappellacci L
J Med Chem; 2017 May; 60(10):4327-4341. PubMed ID: 28447789
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
