210 related articles for article (PubMed ID: 27959508)
1. Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold.
Mishra SJ; Ghosh S; Stothert AR; Dickey CA; Blagg BS
ACS Chem Biol; 2017 Jan; 12(1):244-253. PubMed ID: 27959508
[TBL] [Abstract][Full Text] [Related]
2. Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.
Crowley VM; Khandelwal A; Mishra S; Stothert AR; Huard DJ; Zhao J; Muth A; Duerfeldt AS; Kizziah JL; Lieberman RL; Dickey CA; Blagg BS
J Med Chem; 2016 Apr; 59(7):3471-88. PubMed ID: 27003516
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
Ge J; Normant E; Porter JR; Ali JA; Dembski MS; Gao Y; Georges AT; Grenier L; Pak RH; Patterson J; Sydor JR; Tibbitts TT; Tong JK; Adams J; Palombella VJ
J Med Chem; 2006 Jul; 49(15):4606-15. PubMed ID: 16854066
[TBL] [Abstract][Full Text] [Related]
4. Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer.
Crowley VM; Huard DJE; Lieberman RL; Blagg BSJ
Chemistry; 2017 Nov; 23(62):15775-15782. PubMed ID: 28857290
[TBL] [Abstract][Full Text] [Related]
5. Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Huang KH; Veal JM; Fadden RP; Rice JW; Eaves J; Strachan JP; Barabasz AF; Foley BE; Barta TE; Ma W; Silinski MA; Hu M; Partridge JM; Scott A; DuBois LG; Freed T; Steed PM; Ommen AJ; Smith ED; Hughes PF; Woodward AR; Hanson GJ; McCall WS; Markworth CJ; Hinkley L; Jenks M; Geng L; Lewis M; Otto J; Pronk B; Verleysen K; Hall SE
J Med Chem; 2009 Jul; 52(14):4288-305. PubMed ID: 19552433
[TBL] [Abstract][Full Text] [Related]
6. GRP94/gp96 in Cancer: Biology, Structure, Immunology, and Drug Development.
Wu BX; Hong F; Zhang Y; Ansa-Addo E; Li Z
Adv Cancer Res; 2016; 129():165-90. PubMed ID: 26916005
[TBL] [Abstract][Full Text] [Related]
7. A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production.
Wong MY; Doan ND; DiChiara AS; Papa LJ; Cheah JH; Soule CK; Watson N; Hulleman JD; Shoulders MD
Biochemistry; 2018 May; 57(19):2814-2827. PubMed ID: 29676157
[TBL] [Abstract][Full Text] [Related]
8. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.
Patel HJ; Patel PD; Ochiana SO; Yan P; Sun W; Patel MR; Shah SK; Tramentozzi E; Brooks J; Bolaender A; Shrestha L; Stephani R; Finotti P; Leifer C; Li Z; Gewirth DT; Taldone T; Chiosis G
J Med Chem; 2015 May; 58(9):3922-43. PubMed ID: 25901531
[TBL] [Abstract][Full Text] [Related]
9. Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.
Prince TL; Kijima T; Tatokoro M; Lee S; Tsutsumi S; Yim K; Rivas C; Alarcon S; Schwartz H; Khamit-Kush K; Scroggins BT; Beebe K; Trepel JB; Neckers L
PLoS One; 2015; 10(10):e0141786. PubMed ID: 26517842
[TBL] [Abstract][Full Text] [Related]
10. Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.
Huard DJE; Crowley VM; Du Y; Cordova RA; Sun Z; Tomlin MO; Dickey CA; Koren J; Blair L; Fu H; Blagg BSJ; Lieberman RL
ACS Chem Biol; 2018 Apr; 13(4):933-941. PubMed ID: 29402077
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, and structure--activity relationships for chimeric inhibitors of Hsp90.
Shen G; Wang M; Welch TR; Blagg BS
J Org Chem; 2006 Sep; 71(20):7618-31. PubMed ID: 16995666
[TBL] [Abstract][Full Text] [Related]
12. Organelle-specific Hsp90 inhibitors.
Seo YH
Arch Pharm Res; 2015 Sep; 38(9):1582-90. PubMed ID: 26195286
[TBL] [Abstract][Full Text] [Related]
13. NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.
Huck JD; Que NLS; Immormino RM; Shrestha L; Taldone T; Chiosis G; Gewirth DT
J Biol Chem; 2019 Nov; 294(44):16010-16019. PubMed ID: 31501246
[TBL] [Abstract][Full Text] [Related]
14. Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.
Ghosh S; Shinogle HE; Galeva NA; Dobrowsky RT; Blagg BS
J Biol Chem; 2016 Apr; 291(16):8309-23. PubMed ID: 26872972
[TBL] [Abstract][Full Text] [Related]
15. Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1).
Gómez-Fernández P; Urtasun A; Astobiza I; Mena J; Alloza I; Vandenbroeck K
Int J Mol Sci; 2019 May; 20(10):. PubMed ID: 31108847
[TBL] [Abstract][Full Text] [Related]
16. Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
Que NLS; Crowley VM; Duerfeldt AS; Zhao J; Kent CN; Blagg BSJ; Gewirth DT
J Med Chem; 2018 Apr; 61(7):2793-2805. PubMed ID: 29528635
[TBL] [Abstract][Full Text] [Related]
17. Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
Immormino RM; Metzger LE; Reardon PN; Dollins DE; Blagg BS; Gewirth DT
J Mol Biol; 2009 May; 388(5):1033-42. PubMed ID: 19361515
[TBL] [Abstract][Full Text] [Related]
18. Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.
Huck JD; Que NL; Hong F; Li Z; Gewirth DT
Cell Rep; 2017 Sep; 20(12):2800-2809. PubMed ID: 28930677
[TBL] [Abstract][Full Text] [Related]
19. The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with
Mishra SJ; Liu W; Beebe K; Banerjee M; Kent CN; Munthali V; Koren J; Taylor JA; Neckers LM; Holzbeierlein J; Blagg BSJ
J Med Chem; 2021 Feb; 64(3):1545-1557. PubMed ID: 33428418
[TBL] [Abstract][Full Text] [Related]
20. SNX-2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells.
Wang SX; Ju HQ; Liu KS; Zhang JX; Wang X; Xiang YF; Wang R; Liu JY; Liu QY; Xia M; Xing GW; Liu Z; Wang YF
Biosci Biotechnol Biochem; 2011; 75(8):1540-5. PubMed ID: 21821931
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]