253 related articles for article (PubMed ID: 27959531)
1. Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy.
Ravez S; Spillier Q; Marteau R; Feron O; Frédérick R
J Med Chem; 2017 Feb; 60(4):1227-1237. PubMed ID: 27959531
[TBL] [Abstract][Full Text] [Related]
2. A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism.
Zhao JY; Feng KR; Wang F; Zhang JW; Cheng JF; Lin GQ; Gao D; Tian P
Eur J Med Chem; 2021 May; 217():113379. PubMed ID: 33756126
[TBL] [Abstract][Full Text] [Related]
3. Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015-2020.
Spillier Q; Frédérick R
Expert Opin Ther Pat; 2021 Jul; 31(7):597-608. PubMed ID: 33571419
[No Abstract] [Full Text] [Related]
4. α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).
Ravez S; Corbet C; Spillier Q; Dutu A; Robin AD; Mullarky E; Cantley LC; Feron O; Frédérick R
J Med Chem; 2017 Feb; 60(4):1591-1597. PubMed ID: 28085281
[TBL] [Abstract][Full Text] [Related]
5. The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer.
Zhao X; Fu J; Du J; Xu W
Int J Biol Sci; 2020; 16(9):1495-1506. PubMed ID: 32226297
[TBL] [Abstract][Full Text] [Related]
6. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.
Wang Q; Liberti MV; Liu P; Deng X; Liu Y; Locasale JW; Lai L
Cell Chem Biol; 2017 Jan; 24(1):55-65. PubMed ID: 28042046
[TBL] [Abstract][Full Text] [Related]
7. Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer.
Yoon S; Kim JG; Seo AN; Park SY; Kim HJ; Park JS; Choi GS; Jeong JY; Jun do Y; Yoon GS; Kang BW
Oncology; 2015; 89(6):351-9. PubMed ID: 26439504
[TBL] [Abstract][Full Text] [Related]
8. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
Rohde JM; Brimacombe KR; Liu L; Pacold ME; Yasgar A; Cheff DM; Lee TD; Rai G; Baljinnyam B; Li Z; Simeonov A; Hall MD; Shen M; Sabatini DM; Boxer MB
Bioorg Med Chem; 2018 May; 26(8):1727-1739. PubMed ID: 29555419
[TBL] [Abstract][Full Text] [Related]
9. Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.
Guo J; Gu X; Zheng M; Zhang Y; Chen L; Li H
Bioorg Chem; 2019 Jun; 87():16-22. PubMed ID: 30852233
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.
Mullarky E; Xu J; Robin AD; Huggins DJ; Jennings A; Noguchi N; Olland A; Lakshminarasimhan D; Miller M; Tomita D; Michino M; Su T; Zhang G; Stamford AW; Meinke PT; Kargman S; Cantley LC
Bioorg Med Chem Lett; 2019 Sep; 29(17):2503-2510. PubMed ID: 31327531
[TBL] [Abstract][Full Text] [Related]
11. ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction.
Li X; Gracilla D; Cai L; Zhang M; Yu X; Chen X; Zhang J; Long X; Ding HF; Yan C
Cell Rep; 2021 Sep; 36(12):109706. PubMed ID: 34551291
[TBL] [Abstract][Full Text] [Related]
12. Artemether Exhibits Amoebicidal Activity against Acanthamoeba castellanii through Inhibition of the Serine Biosynthesis Pathway.
Deng Y; Ran W; Man S; Li X; Gao H; Tang W; Tachibana H; Cheng X
Antimicrob Agents Chemother; 2015 Aug; 59(8):4680-8. PubMed ID: 26014935
[TBL] [Abstract][Full Text] [Related]
13. 3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment.
Li M; Wu C; Yang Y; Zheng M; Yu S; Wang J; Chen L; Li H
Cell Oncol (Dordr); 2021 Jun; 44(3):541-556. PubMed ID: 33735398
[TBL] [Abstract][Full Text] [Related]
14. Molecular cloning and expression of phosphoglycerate dehydrogenase and phosphoserine aminotransferase in the serine biosynthetic pathway from Acanthamoeba castellanii.
Deng Y; Wu D; Tachibana H; Cheng X
Parasitol Res; 2015 Apr; 114(4):1387-95. PubMed ID: 25622549
[TBL] [Abstract][Full Text] [Related]
15. Reducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth.
Polet F; Corbet C; Pinto A; Rubio LI; Martherus R; Bol V; Drozak X; Grégoire V; Riant O; Feron O
Oncotarget; 2016 Jan; 7(2):1765-76. PubMed ID: 26625201
[TBL] [Abstract][Full Text] [Related]
16. Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression.
Barnabas GD; Lee JS; Shami T; Harel M; Beck L; Selitrennik M; Jerby-Arnon L; Erez N; Ruppin E; Geiger T
Cancer Res; 2021 Mar; 81(6):1443-1456. PubMed ID: 33500247
[TBL] [Abstract][Full Text] [Related]
17. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Ngo B; Kim E; Osorio-Vasquez V; Doll S; Bustraan S; Liang RJ; Luengo A; Davidson SM; Ali A; Ferraro GB; Fischer GM; Eskandari R; Kang DS; Ni J; Plasger A; Rajasekhar VK; Kastenhuber ER; Bacha S; Sriram RK; Stein BD; Bakhoum SF; Snuderl M; Cotzia P; Healey JH; Mainolfi N; Suri V; Friedman A; Manfredi M; Sabatini DM; Jones DR; Yu M; Zhao JJ; Jain RK; Keshari KR; Davies MA; Vander Heiden MG; Hernando E; Mann M; Cantley LC; Pacold ME
Cancer Discov; 2020 Sep; 10(9):1352-1373. PubMed ID: 32571778
[TBL] [Abstract][Full Text] [Related]
18. Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor
Weinstabl H; Treu M; Rinnenthal J; Zahn SK; Ettmayer P; Bader G; Dahmann G; Kessler D; Rumpel K; Mischerikow N; Savarese F; Gerstberger T; Mayer M; Zoephel A; Schnitzer R; Sommergruber W; Martinelli P; Arnhof H; Peric-Simov B; Hofbauer KS; Garavel G; Scherbantin Y; Mitzner S; Fett TN; Scholz G; Bruchhaus J; Burkard M; Kousek R; Ciftci T; Sharps B; Schrenk A; Harrer C; Haering D; Wolkerstorfer B; Zhang X; Lv X; Du A; Li D; Li Y; Quant J; Pearson M; McConnell DB
J Med Chem; 2019 Sep; 62(17):7976-7997. PubMed ID: 31365252
[TBL] [Abstract][Full Text] [Related]
19. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
Mullarky E; Lucki NC; Beheshti Zavareh R; Anglin JL; Gomes AP; Nicolay BN; Wong JC; Christen S; Takahashi H; Singh PK; Blenis J; Warren JD; Fendt SM; Asara JM; DeNicola GM; Lyssiotis CA; Lairson LL; Cantley LC
Proc Natl Acad Sci U S A; 2016 Feb; 113(7):1778-83. PubMed ID: 26831078
[TBL] [Abstract][Full Text] [Related]
20. The PHGDH enigma: Do cancer cells only need serine or also a redox modulator?
Li AM; Ye J
Cancer Lett; 2020 Apr; 476():97-105. PubMed ID: 32032680
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
