These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells. Risberg K; Redalen KR; Sønstevold L; Bjørnetrø T; Sølvernes J; Ree AH BMC Cancer; 2016 Jul; 16():531. PubMed ID: 27461218 [TBL] [Abstract][Full Text] [Related]
3. Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism. Rahmani M; Aust MM; Attkisson E; Williams DC; Ferreira-Gonzalez A; Grant S Cancer Res; 2013 Feb; 73(4):1340-51. PubMed ID: 23243017 [TBL] [Abstract][Full Text] [Related]
4. Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy. Hu X; Xia M; Wang J; Yu H; Chai J; Zhang Z; Sun Y; Su J; Sun L Biomed Pharmacother; 2020 Sep; 129():110397. PubMed ID: 32585451 [TBL] [Abstract][Full Text] [Related]
5. Bcl-xL inhibition radiosensitizes Pesch AM; Chandler BC; Michmerhuizen AR; Carter HM; Hirsh NH; Wilder-Romans K; Liu M; Ward T; Ritter CL; Nino CA; Jungles KM; Pierce LJ; Rae JM; Speers CW Cancer Res Commun; 2022 Jul; 2(7):679-693. PubMed ID: 36381235 [TBL] [Abstract][Full Text] [Related]
6. PI3K/mTOR dual inhibitor NVP-BEZ235 decreases Mcl-1 expression and sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies, provided that Bim expression is induced. Jebahi A; Villedieu M; Pétigny-Lechartier C; Brotin E; Louis MH; Abeilard E; Giffard F; Guercio M; Briand M; Gauduchon P; Lheureux S; Poulain L Cancer Lett; 2014 Jun; 348(1-2):38-49. PubMed ID: 24650799 [TBL] [Abstract][Full Text] [Related]
7. Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases. Ippen FM; Grosch JK; Subramanian M; Kuter BM; Liederer BM; Plise EG; Mora JL; Nayyar N; Schmidt SP; Giobbie-Hurder A; Martinez-Lage M; Carter SL; Cahill DP; Wakimoto H; Brastianos PK Neuro Oncol; 2019 Nov; 21(11):1401-1411. PubMed ID: 31173106 [TBL] [Abstract][Full Text] [Related]
8. Key Survival Factor, Mcl-1, Correlates with Sensitivity to Combined Bcl-2/Bcl-xL Blockade. Williams MM; Lee L; Hicks DJ; Joly MM; Elion D; Rahman B; McKernan C; Sanchez V; Balko JM; Stricker T; Estrada MV; Cook RS Mol Cancer Res; 2017 Mar; 15(3):259-268. PubMed ID: 28039357 [TBL] [Abstract][Full Text] [Related]
9. mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. Faber AC; Coffee EM; Costa C; Dastur A; Ebi H; Hata AN; Yeo AT; Edelman EJ; Song Y; Tam AT; Boisvert JL; Milano RJ; Roper J; Kodack DP; Jain RK; Corcoran RB; Rivera MN; Ramaswamy S; Hung KE; Benes CH; Engelman JA Cancer Discov; 2014 Jan; 4(1):42-52. PubMed ID: 24163374 [TBL] [Abstract][Full Text] [Related]
10. Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia. Iacovelli S; Ricciardi MR; Allegretti M; Mirabilii S; Licchetta R; Bergamo P; Rinaldo C; Zeuner A; Foà R; Milella M; McCubrey JA; Martelli AM; Tafuri A Oncotarget; 2015 Oct; 6(31):32089-103. PubMed ID: 26392332 [TBL] [Abstract][Full Text] [Related]
11. c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1. Campone M; Noël B; Couriaud C; Grau M; Guillemin Y; Gautier F; Gouraud W; Charbonnel C; Campion L; Jézéquel P; Braun F; Barré B; Coqueret O; Barillé-Nion S; Juin P Mol Cancer; 2011 Sep; 10():110. PubMed ID: 21899728 [TBL] [Abstract][Full Text] [Related]
12. MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma. Lee JS; Tang SS; Ortiz V; Vo TT; Fruman DA Oncotarget; 2015 Nov; 6(34):35202-17. PubMed ID: 26460954 [TBL] [Abstract][Full Text] [Related]
13. Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma. Müller A; Zang C; Chumduri C; Dörken B; Daniel PT; Scholz CW Int J Cancer; 2013 Oct; 133(8):1813-24. PubMed ID: 23580240 [TBL] [Abstract][Full Text] [Related]
14. Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition. Zhang H; Cohen AL; Krishnakumar S; Wapnir IL; Veeriah S; Deng G; Coram MA; Piskun CM; Longacre TA; Herrler M; Frimannsson DO; Telli ML; Dirbas FM; Matin AC; Dairkee SH; Larijani B; Glinsky GV; Bild AH; Jeffrey SS Breast Cancer Res; 2014 Apr; 16(2):R36. PubMed ID: 24708766 [TBL] [Abstract][Full Text] [Related]
15. MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor. Xiao Y; Nimmer P; Sheppard GS; Bruncko M; Hessler P; Lu X; Roberts-Rapp L; Pappano WN; Elmore SW; Souers AJ; Leverson JD; Phillips DC Mol Cancer Ther; 2015 Aug; 14(8):1837-47. PubMed ID: 26013319 [TBL] [Abstract][Full Text] [Related]
16. Low BCL-xL expression in triple-negative breast cancer cells favors chemotherapy efficacy, and this effect is limited by cancer-associated fibroblasts. Nocquet L; Roul J; Lefebvre CC; Duarte L; Campone M; Juin PP; Souazé F Sci Rep; 2024 Jun; 14(1):14177. PubMed ID: 38898061 [TBL] [Abstract][Full Text] [Related]
17. Dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 synergizes with chloroquine to induce apoptosis in embryonal rhabdomyosarcoma. Hugle M; Fulda S Cancer Lett; 2015 Apr; 360(1):1-9. PubMed ID: 25637161 [TBL] [Abstract][Full Text] [Related]
18. Pan-mammalian target of rapamycin (mTOR) inhibitor AZD8055 primes rhabdomyosarcoma cells for ABT-737-induced apoptosis by down-regulating Mcl-1 protein. Preuss E; Hugle M; Reimann R; Schlecht M; Fulda S J Biol Chem; 2013 Dec; 288(49):35287-96. PubMed ID: 24133218 [TBL] [Abstract][Full Text] [Related]
19. Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML. Vachhani P; Bose P; Rahmani M; Grant S Physiol Genomics; 2014 Jul; 46(13):448-56. PubMed ID: 24824212 [TBL] [Abstract][Full Text] [Related]
20. The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition. Peddaboina C; Jupiter D; Fletcher S; Yap JL; Rai A; Tobin RP; Jiang W; Rascoe P; Rogers MK; Smythe WR; Cao X BMC Cancer; 2012 Nov; 12():541. PubMed ID: 23171055 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]