These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
336 related articles for article (PubMed ID: 27979631)
1. Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells. Quirit JG; Lavrenov SN; Poindexter K; Xu J; Kyauk C; Durkin KA; Aronchik I; Tomasiak T; Solomatin YA; Preobrazhenskaya MN; Firestone GL Biochem Pharmacol; 2017 Mar; 127():13-27. PubMed ID: 27979631 [TBL] [Abstract][Full Text] [Related]
2. The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation. Aronchik I; Kundu A; Quirit JG; Firestone GL Mol Cancer Res; 2014 Nov; 12(11):1621-1634. PubMed ID: 25009292 [TBL] [Abstract][Full Text] [Related]
3. Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling. Aronchik I; Chen T; Durkin KA; Horwitz MS; Preobrazhenskaya MN; Bjeldanes LF; Firestone GL Mol Carcinog; 2012 Nov; 51(11):881-94. PubMed ID: 22012859 [TBL] [Abstract][Full Text] [Related]
4. 1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M. Kundu A; Khouri MG; Aryana S; Firestone GL Carcinogenesis; 2017 Dec; 38(12):1207-1217. PubMed ID: 29028954 [TBL] [Abstract][Full Text] [Related]
6. 1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells. Nguyen HH; Lavrenov SN; Sundar SN; Nguyen DH; Tseng M; Marconett CN; Kung J; Staub RE; Preobrazhenskaya MN; Bjeldanes LF; Firestone GL Chem Biol Interact; 2010 Aug; 186(3):255-66. PubMed ID: 20570586 [TBL] [Abstract][Full Text] [Related]
7. Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain. Bruce MC; Kanelis V; Fouladkou F; Debonneville A; Staub O; Rotin D Biochem J; 2008 Oct; 415(1):155-63. PubMed ID: 18498246 [TBL] [Abstract][Full Text] [Related]
8. Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy. Li Y; Zhang L; Zhou J; Luo S; Huang R; Zhao C; Diao A Cell Prolif; 2015 Jun; 48(3):338-47. PubMed ID: 25809873 [TBL] [Abstract][Full Text] [Related]
9. Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells. Poindexter KM; Matthew S; Aronchik I; Firestone GL Cell Biol Toxicol; 2016 Apr; 32(2):103-19. PubMed ID: 27055402 [TBL] [Abstract][Full Text] [Related]
10. Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition. Wang J; Peng Q; Lin Q; Childress C; Carey D; Yang W J Biol Chem; 2010 Apr; 285(16):12279-88. PubMed ID: 20172859 [TBL] [Abstract][Full Text] [Related]
11. NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway. Eide PW; Cekaite L; Danielsen SA; Eilertsen IA; Kjenseth A; Fykerud TA; Ågesen TH; Bruun J; Rivedal E; Lothe RA; Leithe E Cell Signal; 2013 Jan; 25(1):12-8. PubMed ID: 22974840 [TBL] [Abstract][Full Text] [Related]
13. NEDD4: a promising target for cancer therapy. Ye X; Wang L; Shang B; Wang Z; Wei W Curr Cancer Drug Targets; 2014; 14(6):549-56. PubMed ID: 25088038 [TBL] [Abstract][Full Text] [Related]
14. The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer. Su J; Zhou X; Yin X; Wang L; Zhao Z; Hou Y; Zheng N; Xia J; Wang Z Biochem Pharmacol; 2017 Sep; 140():28-40. PubMed ID: 28535906 [TBL] [Abstract][Full Text] [Related]
15. The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters. Aleidi SM; Howe V; Sharpe LJ; Yang A; Rao G; Brown AJ; Gelissen IC J Biol Chem; 2015 Oct; 290(40):24604-13. PubMed ID: 26296893 [TBL] [Abstract][Full Text] [Related]
16. NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. Kuratomi G; Komuro A; Goto K; Shinozaki M; Miyazawa K; Miyazono K; Imamura T Biochem J; 2005 Mar; 386(Pt 3):461-70. PubMed ID: 15496141 [TBL] [Abstract][Full Text] [Related]
17. Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes. Vina-Vilaseca A; Sorkin A J Biol Chem; 2010 Mar; 285(10):7645-56. PubMed ID: 20051513 [TBL] [Abstract][Full Text] [Related]
18. Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells. Tin AS; Park AH; Sundar SN; Firestone GL BMC Biol; 2014 Sep; 12():72. PubMed ID: 25209720 [TBL] [Abstract][Full Text] [Related]
19. N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells. Jump SM; Kung J; Staub R; Kinseth MA; Cram EJ; Yudina LN; Preobrazhenskaya MN; Bjeldanes LF; Firestone GL Biochem Pharmacol; 2008 Feb; 75(3):713-24. PubMed ID: 18023427 [TBL] [Abstract][Full Text] [Related]
20. Cruciferous vegetable-derived indole-3-carbinol prevents coronavirus cell egression mechanisms in tracheal and intestinal 3D in vitro models. Pennarossa G; Arcuri S; Pasquariello R; Gandolfi F; Maranesi M; Brevini TAL Phytochemistry; 2023 Aug; 212():113713. PubMed ID: 37169138 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]