BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

340 related articles for article (PubMed ID: 27979631)

  • 1. Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.
    Quirit JG; Lavrenov SN; Poindexter K; Xu J; Kyauk C; Durkin KA; Aronchik I; Tomasiak T; Solomatin YA; Preobrazhenskaya MN; Firestone GL
    Biochem Pharmacol; 2017 Mar; 127():13-27. PubMed ID: 27979631
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation.
    Aronchik I; Kundu A; Quirit JG; Firestone GL
    Mol Cancer Res; 2014 Nov; 12(11):1621-1634. PubMed ID: 25009292
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling.
    Aronchik I; Chen T; Durkin KA; Horwitz MS; Preobrazhenskaya MN; Bjeldanes LF; Firestone GL
    Mol Carcinog; 2012 Nov; 51(11):881-94. PubMed ID: 22012859
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/β-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M.
    Kundu A; Khouri MG; Aryana S; Firestone GL
    Carcinogenesis; 2017 Dec; 38(12):1207-1217. PubMed ID: 29028954
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation.
    Kundu A; Quirit JG; Khouri MG; Firestone GL
    Mol Carcinog; 2017 Jan; 56(1):49-61. PubMed ID: 26878440
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.
    Nguyen HH; Lavrenov SN; Sundar SN; Nguyen DH; Tseng M; Marconett CN; Kung J; Staub RE; Preobrazhenskaya MN; Bjeldanes LF; Firestone GL
    Chem Biol Interact; 2010 Aug; 186(3):255-66. PubMed ID: 20570586
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.
    Bruce MC; Kanelis V; Fouladkou F; Debonneville A; Staub O; Rotin D
    Biochem J; 2008 Oct; 415(1):155-63. PubMed ID: 18498246
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy.
    Li Y; Zhang L; Zhou J; Luo S; Huang R; Zhao C; Diao A
    Cell Prolif; 2015 Jun; 48(3):338-47. PubMed ID: 25809873
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells.
    Poindexter KM; Matthew S; Aronchik I; Firestone GL
    Cell Biol Toxicol; 2016 Apr; 32(2):103-19. PubMed ID: 27055402
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition.
    Wang J; Peng Q; Lin Q; Childress C; Carey D; Yang W
    J Biol Chem; 2010 Apr; 285(16):12279-88. PubMed ID: 20172859
    [TBL] [Abstract][Full Text] [Related]  

  • 11. NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.
    Eide PW; Cekaite L; Danielsen SA; Eilertsen IA; Kjenseth A; Fykerud TA; Ågesen TH; Bruun J; Rivedal E; Lothe RA; Leithe E
    Cell Signal; 2013 Jan; 25(1):12-8. PubMed ID: 22974840
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of HECT E3 ligases as potential therapy for COVID-19.
    Novelli G; Liu J; Biancolella M; Alonzi T; Novelli A; Patten JJ; Cocciadiferro D; Agolini E; Colona VL; Rizzacasa B; Giannini R; Bigio B; Goletti D; Capobianchi MR; Grelli S; Mann J; McKee TD; Cheng K; Amanat F; Krammer F; Guarracino A; Pepe G; Tomino C; Tandjaoui-Lambiotte Y; Uzunhan Y; Tubiana S; Ghosn J; ; ; ; Notarangelo LD; Su HC; Abel L; Cobat A; Elhanan G; Grzymski JJ; Latini A; Sidhu SS; Jain S; Davey RA; Casanova JL; Wei W; Pandolfi PP
    Cell Death Dis; 2021 Mar; 12(4):310. PubMed ID: 33762578
    [TBL] [Abstract][Full Text] [Related]  

  • 13. NEDD4: a promising target for cancer therapy.
    Ye X; Wang L; Shang B; Wang Z; Wei W
    Curr Cancer Drug Targets; 2014; 14(6):549-56. PubMed ID: 25088038
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer.
    Su J; Zhou X; Yin X; Wang L; Zhao Z; Hou Y; Zheng N; Xia J; Wang Z
    Biochem Pharmacol; 2017 Sep; 140():28-40. PubMed ID: 28535906
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.
    Aleidi SM; Howe V; Sharpe LJ; Yang A; Rao G; Brown AJ; Gelissen IC
    J Biol Chem; 2015 Oct; 290(40):24604-13. PubMed ID: 26296893
    [TBL] [Abstract][Full Text] [Related]  

  • 16. NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.
    Kuratomi G; Komuro A; Goto K; Shinozaki M; Miyazawa K; Miyazono K; Imamura T
    Biochem J; 2005 Mar; 386(Pt 3):461-70. PubMed ID: 15496141
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.
    Vina-Vilaseca A; Sorkin A
    J Biol Chem; 2010 Mar; 285(10):7645-56. PubMed ID: 20051513
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells.
    Tin AS; Park AH; Sundar SN; Firestone GL
    BMC Biol; 2014 Sep; 12():72. PubMed ID: 25209720
    [TBL] [Abstract][Full Text] [Related]  

  • 19. N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells.
    Jump SM; Kung J; Staub R; Kinseth MA; Cram EJ; Yudina LN; Preobrazhenskaya MN; Bjeldanes LF; Firestone GL
    Biochem Pharmacol; 2008 Feb; 75(3):713-24. PubMed ID: 18023427
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cruciferous vegetable-derived indole-3-carbinol prevents coronavirus cell egression mechanisms in tracheal and intestinal 3D in vitro models.
    Pennarossa G; Arcuri S; Pasquariello R; Gandolfi F; Maranesi M; Brevini TAL
    Phytochemistry; 2023 Aug; 212():113713. PubMed ID: 37169138
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.