BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

80 related articles for article (PubMed ID: 27982681)

  • 1. Background levels of neomorphic 2-hydroxyglutarate facilitate proliferation of primary fibroblasts.
    Dvořák A; Zelenka J; Smolková K; Vítek L; JeŽek P
    Physiol Res; 2017 May; 66(2):293-304. PubMed ID: 27982681
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells.
    Smolková K; Dvořák A; Zelenka J; Vítek L; Ježek P
    Int J Biochem Cell Biol; 2015 Aug; 65():125-33. PubMed ID: 26007236
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 2-Hydroxyglutarate in Cancer Cells.
    Ježek P
    Antioxid Redox Signal; 2020 Nov; 33(13):903-926. PubMed ID: 31847543
    [No Abstract]   [Full Text] [Related]  

  • 4. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.
    Shim EH; Livi CB; Rakheja D; Tan J; Benson D; Parekh V; Kho EY; Ghosh AP; Kirkman R; Velu S; Dutta S; Chenna B; Rea SL; Mishur RJ; Li Q; Johnson-Pais TL; Guo L; Bae S; Wei S; Block K; Sudarshan S
    Cancer Discov; 2014 Nov; 4(11):1290-8. PubMed ID: 25182153
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
    Koivunen P; Lee S; Duncan CG; Lopez G; Lu G; Ramkissoon S; Losman JA; Joensuu P; Bergmann U; Gross S; Travins J; Weiss S; Looper R; Ligon KL; Verhaak RG; Yan H; Kaelin WG
    Nature; 2012 Feb; 483(7390):484-8. PubMed ID: 22343896
    [TBL] [Abstract][Full Text] [Related]  

  • 6. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.
    Akbay EA; Moslehi J; Christensen CL; Saha S; Tchaicha JH; Ramkissoon SH; Stewart KM; Carretero J; Kikuchi E; Zhang H; Cohoon TJ; Murray S; Liu W; Uno K; Fisch S; Jones K; Gurumurthy S; Gliser C; Choe S; Keenan M; Son J; Stanley I; Losman JA; Padera R; Bronson RT; Asara JM; Abdel-Wahab O; Amrein PC; Fathi AT; Danial NN; Kimmelman AC; Kung AL; Ligon KL; Yen KE; Kaelin WG; Bardeesy N; Wong KK
    Genes Dev; 2014 Mar; 28(5):479-90. PubMed ID: 24589777
    [TBL] [Abstract][Full Text] [Related]  

  • 7. An olive oil phenolic is a new chemotype of mutant isocitrate dehydrogenase 1 (IDH1) inhibitors.
    Verdura S; Cuyàs E; Lozano-Sánchez J; Bastidas-Velez C; Llorach-Parés L; Fernández-Arroyo S; Hernández-Aguilera A; Joven J; Nonell-Canals A; Bosch-Barrera J; Martin-Castillo B; Vellon L; Sanchez-Martinez M; Segura-Carretero A; Menendez JA
    Carcinogenesis; 2019 Mar; 40(1):27-40. PubMed ID: 30428017
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Drosophila larvae synthesize the putative oncometabolite L-2-hydroxyglutarate during normal developmental growth.
    Li H; Chawla G; Hurlburt AJ; Sterrett MC; Zaslaver O; Cox J; Karty JA; Rosebrock AP; Caudy AA; Tennessen JM
    Proc Natl Acad Sci U S A; 2017 Feb; 114(6):1353-1358. PubMed ID: 28115720
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Quantitative Analysis of Oncometabolite 2-Hydroxyglutarate.
    Yuan BF
    Adv Exp Med Biol; 2021; 1280():161-172. PubMed ID: 33791981
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Isocitrate dehydrogenase mutation as a therapeutic target in gliomas.
    Han CH; Batchelor TT
    Chin Clin Oncol; 2017 Jun; 6(3):33. PubMed ID: 28705010
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.
    Becker-Kettern J; Paczia N; Conrotte JF; Kay DP; Guignard C; Jung PP; Linster CL
    J Biol Chem; 2016 Mar; 291(12):6036-58. PubMed ID: 26774271
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
    Fu X; Chin RM; Vergnes L; Hwang H; Deng G; Xing Y; Pai MY; Li S; Ta L; Fazlollahi F; Chen C; Prins RM; Teitell MA; Nathanson DA; Lai A; Faull KF; Jiang M; Clarke SG; Cloughesy TF; Graeber TG; Braas D; Christofk HR; Jung ME; Reue K; Huang J
    Cell Metab; 2015 Sep; 22(3):508-15. PubMed ID: 26190651
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells.
    Li L; Paz AC; Wilky BA; Johnson B; Galoian K; Rosenberg A; Hu G; Tinoco G; Bodamer O; Trent JC
    PLoS One; 2015; 10(9):e0133813. PubMed ID: 26368816
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Roles of the oncometabolite enantiomers of 2-hydroxyglutarate and their metabolism by diverse dehydrogenases.
    Garcia I; Cornely K; Peterson CN; Berkmen MB
    Essays Biochem; 2024 Jun; ():. PubMed ID: 38919140
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma.
    Nagashima H; Tanaka K; Sasayama T; Irino Y; Sato N; Takeuchi Y; Kyotani K; Mukasa A; Mizukawa K; Sakata J; Yamamoto Y; Hosoda K; Itoh T; Sasaki R; Kohmura E
    Neuro Oncol; 2016 Nov; 18(11):1559-1568. PubMed ID: 27154922
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Circulating oncometabolite D-2-hydroxyglutarate enantiomer is a surrogate marker of isocitrate dehydrogenase-mutated intrahepatic cholangiocarcinomas.
    Delahousse J; Verlingue L; Broutin S; Legoupil C; Touat M; Doucet L; Ammari S; Lacroix L; Ducreux M; Scoazec JY; Malka D; Paci A; Hollebecque A
    Eur J Cancer; 2018 Feb; 90():83-91. PubMed ID: 29274619
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.
    Rendina AR; Pietrak B; Smallwood A; Zhao H; Qi H; Quinn C; Adams ND; Concha N; Duraiswami C; Thrall SH; Sweitzer S; Schwartz B
    Biochemistry; 2013 Jul; 52(26):4563-77. PubMed ID: 23731180
    [TBL] [Abstract][Full Text] [Related]  

  • 18. On the Utility of Short Echo Time (TE) Single Voxel 1H-MRS in Non-Invasive Detection of 2-Hydroxyglutarate (2HG); Challenges and Potential Improvement Illustrated with Animal Models Using MRUI and LCModel.
    Heo H; Kim S; Lee HH; Cho HR; Xu WJ; Lee SH; Park CK; Park S; Choi SH; Kim H
    PLoS One; 2016; 11(1):e0147794. PubMed ID: 26820720
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Volumetric relationship between 2-hydroxyglutarate and FLAIR hyperintensity has potential implications for radiotherapy planning of mutant IDH glioma patients.
    Jafari-Khouzani K; Loebel F; Bogner W; Rapalino O; Gonzalez GR; Gerstner E; Chi AS; Batchelor TT; Rosen BR; Unkelbach J; Shih HA; Cahill DP; Andronesi OC
    Neuro Oncol; 2016 Nov; 18(11):1569-1578. PubMed ID: 27382115
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma.
    de la Fuente MI; Young RJ; Rubel J; Rosenblum M; Tisnado J; Briggs S; Arevalo-Perez J; Cross JR; Campos C; Straley K; Zhu D; Dong C; Thomas A; Omuro AA; Nolan CP; Pentsova E; Kaley TJ; Oh JH; Noeske R; Maher E; Choi C; Gutin PH; Holodny AI; Yen K; DeAngelis LM; Mellinghoff IK; Thakur SB
    Neuro Oncol; 2016 Feb; 18(2):283-90. PubMed ID: 26691210
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.