These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition. Nakagawa T; Takeuchi S; Yamada T; Ebi H; Sano T; Nanjo S; Ishikawa D; Sato M; Hasegawa Y; Sekido Y; Yano S Cancer Res; 2013 Apr; 73(8):2428-34. PubMed ID: 23382048 [TBL] [Abstract][Full Text] [Related]
3. Phase I study of vorinostat with gefitinib in BIM deletion polymorphism/epidermal growth factor receptor mutation double-positive lung cancer. Takeuchi S; Hase T; Shimizu S; Ando M; Hata A; Murakami H; Kawakami T; Nagase K; Yoshimura K; Fujiwara T; Tanimoto A; Nishiyama A; Arai S; Fukuda K; Katakami N; Takahashi T; Hasegawa Y; Ko TK; Ong ST; Yano S Cancer Sci; 2020 Feb; 111(2):561-570. PubMed ID: 31782583 [TBL] [Abstract][Full Text] [Related]
4. Resminostat, a histone deacetylase inhibitor, circumvents tolerance to EGFR inhibitors in EGFR-mutated lung cancer cells with BIM deletion polymorphism. Arai S; Takeuchi S; Fukuda K; Tanimoto A; Nishiyama A; Konishi H; Takagi A; Takahashi H; Ong ST; Yano S J Med Invest; 2020; 67(3.4):343-350. PubMed ID: 33148913 [TBL] [Abstract][Full Text] [Related]
5. Phase I study of combined therapy with vorinostat and gefitinib to treat BIM deletion polymorphism-associated resistance in EGFR-mutant lung cancer (VICTROY-J): a study protocol. Takeuchi S; Yoshimura K; Fujiwara T; Ando M; Shimizu S; Nagase K; Hasegawa Y; Takahashi T; Katakami N; Inoue A; Yano S J Med Invest; 2017; 64(3.4):321-325. PubMed ID: 28955007 [TBL] [Abstract][Full Text] [Related]
6. Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation. Shi P; Oh YT; Deng L; Zhang G; Qian G; Zhang S; Ren H; Wu G; Legendre B; Anderson E; Ramalingam SS; Owonikoko TK; Chen M; Sun SY Clin Cancer Res; 2017 Nov; 23(21):6567-6579. PubMed ID: 28765329 [No Abstract] [Full Text] [Related]
7. Clinical implications of germline BCL2L11 deletion polymorphism in pretreated advanced NSCLC patients with osimertinib therapy. Li X; Zhang D; Li B; Zou B; Wang S; Fan B; Li W; Yu J; Wang L Lung Cancer; 2021 Jan; 151():39-43. PubMed ID: 33296806 [TBL] [Abstract][Full Text] [Related]
8. Overcoming acquired resistance of epidermal growth factor receptor-mutant non-small cell lung cancer cells to osimertinib by combining osimertinib with the histone deacetylase inhibitor panobinostat (LBH589). Zang H; Qian G; Zong D; Fan S; Owonikoko TK; Ramalingam SS; Sun SY Cancer; 2020 Jan; 126(9):2024-2033. PubMed ID: 31999837 [TBL] [Abstract][Full Text] [Related]
9. ERK inhibition effectively overcomes acquired resistance of epidermal growth factor receptor-mutant non-small cell lung cancer cells to osimertinib. Li Y; Zang H; Qian G; Owonikoko TK; Ramalingam SR; Sun SY Cancer; 2020 Mar; 126(6):1339-1350. PubMed ID: 31821539 [TBL] [Abstract][Full Text] [Related]
10. Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation. Hayakawa D; Takahashi F; Mitsuishi Y; Tajima K; Hidayat M; Winardi W; Ihara H; Kanamori K; Matsumoto N; Asao T; Ko R; Shukuya T; Takamochi K; Hayashi T; Suehara Y; Takeda Nakamura I; Ueno T; Kohsaka S; Mano H; Takahashi K Thorac Cancer; 2020 Jan; 11(1):140-149. PubMed ID: 31758670 [TBL] [Abstract][Full Text] [Related]
11. BIM Deletion Polymorphism Confers Resistance to Osimertinib in EGFR T790M Lung Cancer: a Case Report and Literature Review. Li X; Wang S; Li B; Wang Z; Shang S; Shao Y; Sun X; Wang L Target Oncol; 2018 Aug; 13(4):517-523. PubMed ID: 29907952 [TBL] [Abstract][Full Text] [Related]
13. Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis. Zhao W; Yu D; Chen Z; Yao W; Yang J; Ramalingam SS; Sun SY Cancer Lett; 2021 Oct; 519():141-149. PubMed ID: 34245854 [TBL] [Abstract][Full Text] [Related]
14. Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity. Ballard P; Yates JW; Yang Z; Kim DW; Yang JC; Cantarini M; Pickup K; Jordan A; Hickey M; Grist M; Box M; Johnström P; Varnäs K; Malmquist J; Thress KS; Jänne PA; Cross D Clin Cancer Res; 2016 Oct; 22(20):5130-5140. PubMed ID: 27435396 [TBL] [Abstract][Full Text] [Related]
15. Aspirin sensitizes osimertinib-resistant NSCLC cells in vitro and in vivo via Bim-dependent apoptosis induction. Han R; Hao S; Lu C; Zhang C; Lin C; Li L; Wang Y; Hu C; He Y Mol Oncol; 2020 Jun; 14(6):1152-1169. PubMed ID: 32239624 [TBL] [Abstract][Full Text] [Related]
16. EGFR-Mutated Lung Cancers Resistant to Osimertinib through EGFR C797S Respond to First-Generation Reversible EGFR Inhibitors but Eventually Acquire EGFR T790M/C797S in Preclinical Models and Clinical Samples. Rangachari D; To C; Shpilsky JE; VanderLaan PA; Kobayashi SS; Mushajiang M; Lau CJ; Paweletz CP; Oxnard GR; Jänne PA; Costa DB J Thorac Oncol; 2019 Nov; 14(11):1995-2002. PubMed ID: 31377341 [TBL] [Abstract][Full Text] [Related]
17. Trametinib overcomes KRAS-G12V-induced osimertinib resistance in a leptomeningeal carcinomatosis model of EGFR-mutant lung cancer. Fukuda K; Otani S; Takeuchi S; Arai S; Nanjo S; Tanimoto A; Nishiyama A; Naoki K; Yano S Cancer Sci; 2021 Sep; 112(9):3784-3795. PubMed ID: 34145930 [TBL] [Abstract][Full Text] [Related]
18. ID1 mediates resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer through epithelial-mesenchymal transition. Liu K; Chen X; Wu L; Chen S; Fang N; Cai L; Jia J BMC Pulm Med; 2021 May; 21(1):163. PubMed ID: 33992097 [TBL] [Abstract][Full Text] [Related]
19. Inhibition of Bcl-2 and Bcl-xL overcomes the resistance to the third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer. Lu Y; Bian D; Zhang X; Zhang H; Zhu Z Mol Med Rep; 2021 Jan; 23(1):. PubMed ID: 33200796 [TBL] [Abstract][Full Text] [Related]
20. Efficacy of EGFR tyrosine kinase inhibitors in patients having EGFR-activating mutations with or without BIM polymorphisms. Ariyasu R; Yanagitani N; Tadokoro K; Yamaguchi T; Uchibori K; Kitazono S; Fujita N; Katayama R; Nishio M Cancer Chemother Pharmacol; 2020 Oct; 86(4):517-525. PubMed ID: 32948919 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]