156 related articles for article (PubMed ID: 27994735)
1. Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
Wang X; Liu J; Zhang W; Stashko MA; Nichols J; Miley MJ; Norris-Drouin J; Chen Z; Machius M; DeRyckere D; Wood E; Graham DK; Earp HS; Kireev D; Frye SV
ACS Med Chem Lett; 2016 Dec; 7(12):1044-1049. PubMed ID: 27994735
[TBL] [Abstract][Full Text] [Related]
2. Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
McIver AL; Zhang W; Liu Q; Jiang X; Stashko MA; Nichols J; Miley MJ; Norris-Drouin J; Machius M; DeRyckere D; Wood E; Graham DK; Earp HS; Kireev D; Frye SV; Wang X
ChemMedChem; 2017 Feb; 12(3):207-213. PubMed ID: 28032464
[TBL] [Abstract][Full Text] [Related]
3. Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors.
Kong D; Tian Q; Chen Z; Zheng H; Stashko MA; Yan D; Earp HS; Frye SV; DeRyckere D; Kireev D; Graham DK; Wang X
J Med Chem; 2024 Apr; 67(7):5866-5882. PubMed ID: 38556760
[TBL] [Abstract][Full Text] [Related]
4. UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
Zheng H; Zhao J; Li B; Zhang W; Stashko MA; Minson KA; Huey MG; Zhou Y; Earp HS; Kireev D; Graham DK; DeRyckere D; Frye SV; Wang X
Eur J Med Chem; 2021 Aug; 220():113534. PubMed ID: 34038857
[TBL] [Abstract][Full Text] [Related]
5. Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development.
Park TH; Bae SH; Bong SM; Ryu SE; Jang H; Lee BI
Int J Mol Sci; 2020 Oct; 21(21):. PubMed ID: 33114206
[TBL] [Abstract][Full Text] [Related]
6. Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK.
Bernsmeier C; Pop OT; Singanayagam A; Triantafyllou E; Patel VC; Weston CJ; Curbishley S; Sadiq F; Vergis N; Khamri W; Bernal W; Auzinger G; Heneghan M; Ma Y; Jassem W; Heaton ND; Adams DH; Quaglia A; Thursz MR; Wendon J; Antoniades CG
Gastroenterology; 2015 Mar; 148(3):603-615.e14. PubMed ID: 25479139
[TBL] [Abstract][Full Text] [Related]
7. Development of [
Wong SW; Vivash L; Mudududdla R; Nguyen N; Hermans SJ; Shackleford DM; Field J; Xue L; Aprico A; Hancock NC; Haskali M; Stashko MA; Frye SV; Wang X; Binder MD; Ackermann U; Parker MW; Kilpatrick TJ; Baell JB
Eur J Med Chem; 2021 Dec; 226():113822. PubMed ID: 34563964
[TBL] [Abstract][Full Text] [Related]
8. MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system.
Huelse JM; Fridlyand DM; Earp S; DeRyckere D; Graham DK
Pharmacol Ther; 2020 Sep; 213():107577. PubMed ID: 32417270
[TBL] [Abstract][Full Text] [Related]
9. The proto-oncogene Mer tyrosine kinase is a novel therapeutic target in mantle cell lymphoma.
Shi C; Li X; Wang X; Ding N; Ping L; Shi Y; Mi L; Lai Y; Song Y; Zhu J
J Hematol Oncol; 2018 Mar; 11(1):43. PubMed ID: 29554921
[TBL] [Abstract][Full Text] [Related]
10. Antagonistic Coevolution of MER Tyrosine Kinase Expression and Function.
Evans AL; Blackburn JWD; Taruc K; Kipp A; Dirk BS; Hunt NR; Barr SD; Dikeakos JD; Heit B
Mol Biol Evol; 2017 Jul; 34(7):1613-1628. PubMed ID: 28369510
[TBL] [Abstract][Full Text] [Related]
11. Expression of TAM-R in Human Immune Cells and Unique Regulatory Function of MerTK in IL-10 Production by Tolerogenic DC.
Giroud P; Renaudineau S; Gudefin L; Calcei A; Menguy T; Rozan C; Mizrahi J; Caux C; Duong V; Valladeau-Guilemond J
Front Immunol; 2020; 11():564133. PubMed ID: 33101282
[TBL] [Abstract][Full Text] [Related]
12. BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity.
Bae SH; Kim JH; Park TH; Lee K; Lee BI; Jang H
Exp Mol Med; 2022 Sep; 54(9):1450-1460. PubMed ID: 36056187
[TBL] [Abstract][Full Text] [Related]
13. MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation.
Nishi C; Yanagihashi Y; Segawa K; Nagata S
J Biol Chem; 2019 May; 294(18):7221-7230. PubMed ID: 30846565
[TBL] [Abstract][Full Text] [Related]
14. MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents.
McDaniel NK; Cummings CT; Iida M; Hülse J; Pearson HE; Vasileiadi E; Parker RE; Orbuch RA; Ondracek OJ; Welke NB; Kang GH; Davies KD; Wang X; Frye SV; Earp HS; Harari PM; Kimple RJ; DeRyckere D; Graham DK; Wheeler DL
Mol Cancer Ther; 2018 Nov; 17(11):2297-2308. PubMed ID: 30093568
[TBL] [Abstract][Full Text] [Related]
15. MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme.
Sufit A; Lee-Sherick AB; DeRyckere D; Rupji M; Dwivedi B; Varella-Garcia M; Pierce AM; Kowalski J; Wang X; Frye SV; Earp HS; Keating AK; Graham DK
PLoS One; 2016; 11(10):e0165107. PubMed ID: 27783662
[TBL] [Abstract][Full Text] [Related]
16. Interleukin 17 regulates Mer tyrosine kinase-positive cells in Pseudomonas aeruginosa keratitis.
Li C; McClellan SA; Barrett R; Hazlett LD
Invest Ophthalmol Vis Sci; 2014 Oct; 55(10):6886-900. PubMed ID: 25298414
[TBL] [Abstract][Full Text] [Related]
17. MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme.
Knubel KH; Pernu BM; Sufit A; Nelson S; Pierce AM; Keating AK
Oncotarget; 2014 Mar; 5(5):1338-51. PubMed ID: 24658326
[TBL] [Abstract][Full Text] [Related]
18. Structure-activity relationship of 7-aryl-2-anilino-pyrrolopyrimidines as Mer and Axl tyrosine kinase inhibitors.
Chung SH; Park J; Lee JW; Song J; Jung D; Min KH
J Enzyme Inhib Med Chem; 2020 Dec; 35(1):1822-1833. PubMed ID: 32972253
[TBL] [Abstract][Full Text] [Related]
19. Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy.
Cackowski FC; Eber MR; Rhee J; Decker AM; Yumoto K; Berry JE; Lee E; Shiozawa Y; Jung Y; Aguirre-Ghiso JA; Taichman RS
J Cell Biochem; 2017 Apr; 118(4):891-902. PubMed ID: 27753136
[TBL] [Abstract][Full Text] [Related]
20. MERTK Inhibition: Potential as a Treatment Strategy in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer.
Chen CJ; Liu YP
Pharmaceuticals (Basel); 2021 Feb; 14(2):. PubMed ID: 33562150
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]