These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
554 related articles for article (PubMed ID: 27996267)
1. Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions. Jackson PA; Widen JC; Harki DA; Brummond KM J Med Chem; 2017 Feb; 60(3):839-885. PubMed ID: 27996267 [TBL] [Abstract][Full Text] [Related]
2. Kinetics and Thermodynamics of Reversible Thiol Additions to Mono- and Diactivated Michael Acceptors: Implications for the Design of Drugs That Bind Covalently to Cysteines. Krenske EH; Petter RC; Houk KN J Org Chem; 2016 Dec; 81(23):11726-11733. PubMed ID: 27934455 [TBL] [Abstract][Full Text] [Related]
3. Mechanistic study of the reaction of thiol-containing enzymes with alpha,beta-unsaturated carbonyl substrates by computation and chemoassays. Paasche A; Schiller M; Schirmeister T; Engels B ChemMedChem; 2010 Jun; 5(6):869-80. PubMed ID: 20401893 [TBL] [Abstract][Full Text] [Related]
4. Dynamic thiol exchange with β-sulfido-α,β-unsaturated carbonyl compounds and dithianes. Joshi G; Anslyn EV Org Lett; 2012 Sep; 14(18):4714-7. PubMed ID: 22934665 [TBL] [Abstract][Full Text] [Related]
5. Multiplexed Thiol Reactivity Profiling for Target Discovery of Electrophilic Natural Products. Tian C; Sun R; Liu K; Fu L; Liu X; Zhou W; Yang Y; Yang J Cell Chem Biol; 2017 Nov; 24(11):1416-1427.e5. PubMed ID: 28988947 [TBL] [Abstract][Full Text] [Related]
6. Thiol reactivity and its impact on the ciliate toxicity of α,β-unsaturated aldehydes, ketones, and esters. Böhme A; Thaens D; Schramm F; Paschke A; Schüürmann G Chem Res Toxicol; 2010 Dec; 23(12):1905-12. PubMed ID: 20923215 [TBL] [Abstract][Full Text] [Related]
7. Predicting Michael-acceptor reactivity and toxicity through quantum chemical transition-state calculations. Mulliner D; Wondrousch D; Schüürmann G Org Biomol Chem; 2011 Dec; 9(24):8400-12. PubMed ID: 22048735 [TBL] [Abstract][Full Text] [Related]
8. Quantum Descriptors for Predicting and Understanding the Structure-Activity Relationships of Michael Acceptor Warheads. Liu R; Vázquez-Montelongo EA; Ma S; Shen J J Chem Inf Model; 2023 Aug; 63(15):4912-4923. PubMed ID: 37463342 [TBL] [Abstract][Full Text] [Related]
9. From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action. Tran QTN; Tan DWS; Wong WSF; Chai CLL Eur J Med Chem; 2020 Oct; 204():112481. PubMed ID: 32712435 [TBL] [Abstract][Full Text] [Related]
10. Systematic modulation of Michael-type reactivity of thiols through the use of charged amino acids. Lutolf MP; Tirelli N; Cerritelli S; Cavalli L; Hubbell JA Bioconjug Chem; 2001; 12(6):1051-6. PubMed ID: 11716699 [TBL] [Abstract][Full Text] [Related]
11. Organocatalytic asymmetric sulfa-Michael addition of thiols to α,β-unsaturated hexafluoroisopropyl esters: expeditious access to (R)-thiazesim. Fang X; Li J; Wang CJ Org Lett; 2013 Jul; 15(13):3448-51. PubMed ID: 23772965 [TBL] [Abstract][Full Text] [Related]
12. A sensitive and selective fluorescent thiol probe in water based on the conjugate 1,4-addition of thiols to alpha,beta-unsaturated ketones. Lin W; Yuan L; Cao Z; Feng Y; Long L Chemistry; 2009; 15(20):5096-103. PubMed ID: 19343759 [TBL] [Abstract][Full Text] [Related]
13. Retro-aza-Michael reaction of an o-aminophenol adduct in protic solvents inspired by natural products. Takenaka K; Kaneko K; Takahashi N; Nishimura S; Kakeya H Bioorg Med Chem; 2021 Apr; 35():116059. PubMed ID: 33611014 [TBL] [Abstract][Full Text] [Related]
14. Nucleophilicity of Glutathione: A Link to Michael Acceptor Reactivities. Mayer RJ; Ofial AR Angew Chem Int Ed Engl; 2019 Dec; 58(49):17704-17708. PubMed ID: 31560405 [TBL] [Abstract][Full Text] [Related]
15. Synthesis of novel estrone analogs by incorporation of thiophenols via conjugate addition to an enone side chain. Kopel LC; Ahmed MS; Halaweish FT Steroids; 2013 Nov; 78(11):1119-25. PubMed ID: 23899492 [TBL] [Abstract][Full Text] [Related]
16. Asymmetric sulfa-Michael addition to α-substituted vinyl ketones catalyzed by chiral primary amine. Fu N; Zhang L; Luo S; Cheng JP Org Lett; 2014 Sep; 16(17):4626-9. PubMed ID: 25144533 [TBL] [Abstract][Full Text] [Related]
17. Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles. Widen JC; Kempema AM; Baur JW; Skopec HM; Edwards JT; Brown TJ; Brown DA; Meece FA; Harki DA ChemMedChem; 2018 Feb; 13(4):303-311. PubMed ID: 29349898 [TBL] [Abstract][Full Text] [Related]
18. Diastereodivergent asymmetric sulfa-Michael additions of α-branched enones using a single chiral organic catalyst. Tian X; Cassani C; Liu Y; Moran A; Urakawa A; Galzerano P; Arceo E; Melchiorre P J Am Chem Soc; 2011 Nov; 133(44):17934-41. PubMed ID: 21936561 [TBL] [Abstract][Full Text] [Related]
19. Ionic liquid catalysed reaction of thiols with α,β-unsaturated carbonyl compounds--remarkable influence of the C-2 hydrogen and the anion. Sarkar A; Roy SR; Chakraborti AK Chem Commun (Camb); 2011 Apr; 47(15):4538-40. PubMed ID: 21387055 [TBL] [Abstract][Full Text] [Related]
20. Abiotic sulfhydryl reactivity: a predictor of aquatic toxicity for carbonyl-containing alpha,beta-unsaturated compounds. Yarbrough JW; Schultz TW Chem Res Toxicol; 2007 Mar; 20(3):558-62. PubMed ID: 17319700 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]