BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

521 related articles for article (PubMed ID: 27996267)

  • 1. Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.
    Jackson PA; Widen JC; Harki DA; Brummond KM
    J Med Chem; 2017 Feb; 60(3):839-885. PubMed ID: 27996267
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Kinetics and Thermodynamics of Reversible Thiol Additions to Mono- and Diactivated Michael Acceptors: Implications for the Design of Drugs That Bind Covalently to Cysteines.
    Krenske EH; Petter RC; Houk KN
    J Org Chem; 2016 Dec; 81(23):11726-11733. PubMed ID: 27934455
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanistic study of the reaction of thiol-containing enzymes with alpha,beta-unsaturated carbonyl substrates by computation and chemoassays.
    Paasche A; Schiller M; Schirmeister T; Engels B
    ChemMedChem; 2010 Jun; 5(6):869-80. PubMed ID: 20401893
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Dynamic thiol exchange with β-sulfido-α,β-unsaturated carbonyl compounds and dithianes.
    Joshi G; Anslyn EV
    Org Lett; 2012 Sep; 14(18):4714-7. PubMed ID: 22934665
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Multiplexed Thiol Reactivity Profiling for Target Discovery of Electrophilic Natural Products.
    Tian C; Sun R; Liu K; Fu L; Liu X; Zhou W; Yang Y; Yang J
    Cell Chem Biol; 2017 Nov; 24(11):1416-1427.e5. PubMed ID: 28988947
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Thiol reactivity and its impact on the ciliate toxicity of α,β-unsaturated aldehydes, ketones, and esters.
    Böhme A; Thaens D; Schramm F; Paschke A; Schüürmann G
    Chem Res Toxicol; 2010 Dec; 23(12):1905-12. PubMed ID: 20923215
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Predicting Michael-acceptor reactivity and toxicity through quantum chemical transition-state calculations.
    Mulliner D; Wondrousch D; Schüürmann G
    Org Biomol Chem; 2011 Dec; 9(24):8400-12. PubMed ID: 22048735
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Quantum Descriptors for Predicting and Understanding the Structure-Activity Relationships of Michael Acceptor Warheads.
    Liu R; Vázquez-Montelongo EA; Ma S; Shen J
    J Chem Inf Model; 2023 Aug; 63(15):4912-4923. PubMed ID: 37463342
    [TBL] [Abstract][Full Text] [Related]  

  • 9. From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action.
    Tran QTN; Tan DWS; Wong WSF; Chai CLL
    Eur J Med Chem; 2020 Oct; 204():112481. PubMed ID: 32712435
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Systematic modulation of Michael-type reactivity of thiols through the use of charged amino acids.
    Lutolf MP; Tirelli N; Cerritelli S; Cavalli L; Hubbell JA
    Bioconjug Chem; 2001; 12(6):1051-6. PubMed ID: 11716699
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Organocatalytic asymmetric sulfa-Michael addition of thiols to α,β-unsaturated hexafluoroisopropyl esters: expeditious access to (R)-thiazesim.
    Fang X; Li J; Wang CJ
    Org Lett; 2013 Jul; 15(13):3448-51. PubMed ID: 23772965
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A sensitive and selective fluorescent thiol probe in water based on the conjugate 1,4-addition of thiols to alpha,beta-unsaturated ketones.
    Lin W; Yuan L; Cao Z; Feng Y; Long L
    Chemistry; 2009; 15(20):5096-103. PubMed ID: 19343759
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Retro-aza-Michael reaction of an o-aminophenol adduct in protic solvents inspired by natural products.
    Takenaka K; Kaneko K; Takahashi N; Nishimura S; Kakeya H
    Bioorg Med Chem; 2021 Apr; 35():116059. PubMed ID: 33611014
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Nucleophilicity of Glutathione: A Link to Michael Acceptor Reactivities.
    Mayer RJ; Ofial AR
    Angew Chem Int Ed Engl; 2019 Dec; 58(49):17704-17708. PubMed ID: 31560405
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis of novel estrone analogs by incorporation of thiophenols via conjugate addition to an enone side chain.
    Kopel LC; Ahmed MS; Halaweish FT
    Steroids; 2013 Nov; 78(11):1119-25. PubMed ID: 23899492
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Asymmetric sulfa-Michael addition to α-substituted vinyl ketones catalyzed by chiral primary amine.
    Fu N; Zhang L; Luo S; Cheng JP
    Org Lett; 2014 Sep; 16(17):4626-9. PubMed ID: 25144533
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles.
    Widen JC; Kempema AM; Baur JW; Skopec HM; Edwards JT; Brown TJ; Brown DA; Meece FA; Harki DA
    ChemMedChem; 2018 Feb; 13(4):303-311. PubMed ID: 29349898
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Diastereodivergent asymmetric sulfa-Michael additions of α-branched enones using a single chiral organic catalyst.
    Tian X; Cassani C; Liu Y; Moran A; Urakawa A; Galzerano P; Arceo E; Melchiorre P
    J Am Chem Soc; 2011 Nov; 133(44):17934-41. PubMed ID: 21936561
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ionic liquid catalysed reaction of thiols with α,β-unsaturated carbonyl compounds--remarkable influence of the C-2 hydrogen and the anion.
    Sarkar A; Roy SR; Chakraborti AK
    Chem Commun (Camb); 2011 Apr; 47(15):4538-40. PubMed ID: 21387055
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Abiotic sulfhydryl reactivity: a predictor of aquatic toxicity for carbonyl-containing alpha,beta-unsaturated compounds.
    Yarbrough JW; Schultz TW
    Chem Res Toxicol; 2007 Mar; 20(3):558-62. PubMed ID: 17319700
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 27.