BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 27999204)

  • 1. Mesothelin-targeted immunotoxin RG7787 has synergistic anti-tumor activity when combined with taxanes.
    Kolyvas E; Rudloff M; Poruchynsky M; Landsman R; Hollevoet K; Venzon D; Alewine C
    Oncotarget; 2017 Feb; 8(6):9189-9199. PubMed ID: 27999204
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Efficacy of Anti-mesothelin Immunotoxin RG7787 plus Nab-Paclitaxel against Mesothelioma Patient-Derived Xenografts and Mesothelin as a Biomarker of Tumor Response.
    Zhang J; Khanna S; Jiang Q; Alewine C; Miettinen M; Pastan I; Hassan R
    Clin Cancer Res; 2017 Mar; 23(6):1564-1574. PubMed ID: 27635089
    [No Abstract]   [Full Text] [Related]  

  • 3. In vitro and in vivo activity of the low-immunogenic antimesothelin immunotoxin RG7787 in pancreatic cancer.
    Hollevoet K; Mason-Osann E; Liu XF; Imhof-Jung S; Niederfellner G; Pastan I
    Mol Cancer Ther; 2014 Aug; 13(8):2040-9. PubMed ID: 24928849
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers.
    Alewine C; Xiang L; Yamori T; Niederfellner G; Bosslet K; Pastan I
    Mol Cancer Ther; 2014 Nov; 13(11):2653-61. PubMed ID: 25239937
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Anti-Mesothelin Recombinant Immunotoxin Therapy for Colorectal Cancer.
    Cerise A; Bera TK; Liu X; Wei J; Pastan I
    Clin Colorectal Cancer; 2019 Sep; 18(3):192-199.e1. PubMed ID: 31345777
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis.
    Liu XF; Xiang L; Zhou Q; Carralot JP; Prunotto M; Niederfellner G; Pastan I
    Proc Natl Acad Sci U S A; 2016 Sep; 113(38):10666-71. PubMed ID: 27601652
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Anticancer Effects of Mesothelin-Targeted Immunotoxin Therapy Are Regulated by Tyrosine Kinase DDR1.
    Ali-Rahmani F; FitzGerald DJ; Martin S; Patel P; Prunotto M; Ormanoglu P; Thomas C; Pastan I
    Cancer Res; 2016 Mar; 76(6):1560-8. PubMed ID: 26719540
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Methylation-associated partial down-regulation of mesothelin causes resistance to anti-mesothelin immunotoxins in a pancreatic cancer cell line.
    Hollevoet K; Mason-Osann E; Müller F; Pastan I
    PLoS One; 2015; 10(3):e0122462. PubMed ID: 25803818
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins.
    Awuah P; Bera TK; Folivi M; Chertov O; Pastan I
    Mol Cancer Ther; 2016 Jul; 15(7):1648-55. PubMed ID: 27196771
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Killing of resistant cancer cells with low Bak by a combination of an antimesothelin immunotoxin and a TRAIL Receptor 2 agonist antibody.
    Du X; Xiang L; Mackall C; Pastan I
    Clin Cancer Res; 2011 Sep; 17(18):5926-34. PubMed ID: 21813632
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma.
    Alewine C; Ahmad M; Peer CJ; Hu ZI; Lee MJ; Yuno A; Kindrick JD; Thomas A; Steinberg SM; Trepel JB; Figg WD; Hassan R; Pastan I
    Clin Cancer Res; 2020 Feb; 26(4):828-836. PubMed ID: 31792036
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Comparative benefits of Nab-paclitaxel over gemcitabine or polysorbate-based docetaxel in experimental pancreatic cancer.
    Awasthi N; Zhang C; Schwarz AM; Hinz S; Wang C; Williams NS; Schwarz MA; Schwarz RE
    Carcinogenesis; 2013 Oct; 34(10):2361-9. PubMed ID: 23803690
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy.
    Bauss F; Lechmann M; Krippendorff BF; Staack R; Herting F; Festag M; Imhof-Jung S; Hesse F; Pompiati M; Kollmorgen G; da Silva Mateus Seidl R; Bossenmaier B; Lau W; Schantz C; Stracke JO; Brinkmann U; Onda M; Pastan I; Bosslet K; Niederfellner G
    Mol Oncol; 2016 Oct; 10(8):1317-29. PubMed ID: 27507537
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody-drug conjugates from synthetic antibody libraries.
    Hsu HJ; Tung CP; Yu CM; Chen CY; Chen HS; Huang YC; Tsai PH; Lin SI; Peng HP; Chiu YK; Tsou YL; Kuo WY; Jian JW; Hung FH; Hsieh CY; Hsiao M; Chuang SS; Shen CN; Wang YA; Yang AS
    Sci Rep; 2021 Jul; 11(1):15430. PubMed ID: 34326410
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma.
    Eberle-Singh JA; Sagalovskiy I; Maurer HC; Sastra SA; Palermo CF; Decker AR; Kim MJ; Sheedy J; Mollin A; Cao L; Hu J; Branstrom A; Weetall M; Olive KP
    Clin Cancer Res; 2019 Sep; 25(18):5548-5560. PubMed ID: 31175095
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A re-engineered immunotoxin shows promising preclinical activity in ovarian cancer.
    Kollmorgen G; Palme K; Seidl A; Scheiblich S; Birzele F; Wilson S; Clemens C; Voss E; Kaufmann M; Hirzel K; Rieder N; Krippendorff BF; Herting F; Niederfellner G
    Sci Rep; 2017 Dec; 7(1):18086. PubMed ID: 29273809
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase.
    Marcus AI; Zhou J; O'Brate A; Hamel E; Wong J; Nivens M; El-Naggar A; Yao TP; Khuri FR; Giannakakou P
    Cancer Res; 2005 May; 65(9):3883-93. PubMed ID: 15867388
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models.
    Tu MJ; Ho PY; Zhang QY; Jian C; Qiu JX; Kim EJ; Bold RJ; Gonzalez FJ; Bi H; Yu AM
    Cancer Lett; 2019 Feb; 442():82-90. PubMed ID: 30389433
    [TBL] [Abstract][Full Text] [Related]  

  • 19. S-1 plus nab-paclitaxel is a promising regimen for pancreatic cancer in a preclinical model.
    Suenaga M; Yamada S; Fujii T; Tanaka C; Kanda M; Nakayama G; Sugimoto H; Koike M; Fujiwara M; Kodera Y
    J Surg Oncol; 2016 Mar; 113(4):413-9. PubMed ID: 27100026
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Augmentation of response to nab-paclitaxel by inhibition of insulin-like growth factor (IGF) signaling in preclinical pancreatic cancer models.
    Awasthi N; Scire E; Monahan S; Grojean M; Zhang E; Schwarz MA; Schwarz RE
    Oncotarget; 2016 Jul; 7(30):46988-47001. PubMed ID: 27127884
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.