BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

127 related articles for article (PubMed ID: 28008665)

  • 1. Discovery of novel potent nuclear factor kappa-B inhibitors (IKK-β) via extensive ligand-based modeling and virtual screening.
    Al-Sha'er MA; Almazari IS; Taha MO
    J Mol Recognit; 2017 Jun; 30(6):. PubMed ID: 28008665
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.
    Taha MO; Al-Sha'er MA; Khanfar MA; Al-Nadaf AH
    Eur J Med Chem; 2014 Sep; 84():454-65. PubMed ID: 25050878
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ligand Based Pharmacophore Modeling Followed by Biological Screening Lead to Discovery of Novel PDK1 Inhibitors as Anticancer Agents.
    Mansi I; Al-Sha'er MA; Mhaidat N; Taha M
    Anticancer Agents Med Chem; 2020; 20(4):476-485. PubMed ID: 31889497
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Elaborate ligand-based modeling and subsequent synthetic exploration unveil new nanomolar Ca2+/calmodulin-dependent protein kinase II inhibitory leads.
    Shahin R; Taha MO
    Bioorg Med Chem; 2012 Jan; 20(1):377-400. PubMed ID: 22112539
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis.
    Al-Sha'er MA; Al-Aqtash RA; Taha MO
    Med Chem; 2019; 15(6):588-601. PubMed ID: 30799792
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.
    Al-Sha'er MA; Khanfar MA; Taha MO
    J Mol Model; 2014 Jan; 20(1):2080. PubMed ID: 24469103
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Elaborate ligand-based modeling coupled with QSAR analysis and in silico screening reveal new potent acetylcholinesterase inhibitors.
    Abuhamdah S; Habash M; Taha MO
    J Comput Aided Mol Des; 2013 Dec; 27(12):1075-92. PubMed ID: 24338032
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of potent IRAK-4 inhibitors as potential anti-inflammatory and anticancer agents using structure-based exploration of IRAK-4 pharmacophoric space coupled with QSAR analyses.
    Khanfar MA; Alqtaishat S
    Comput Biol Chem; 2019 Apr; 79():147-154. PubMed ID: 30818109
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of novel inhibitors for Pim-1 kinase using pharmacophore modeling based on a novel method for selecting pharmacophore generation subsets.
    Shahin R; Swellmeen L; Shaheen O; Aboalhaija N; Habash M
    J Comput Aided Mol Des; 2016 Jan; 30(1):39-68. PubMed ID: 26685860
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Elaborate ligand-based modeling reveal new migration inhibitory factor inhibitors.
    Al-Sha'er MA; VanPatten S; Al-Abed Y; Taha MO
    J Mol Graph Model; 2013 May; 42():104-14. PubMed ID: 23603608
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of new human epidermal growth factor receptor-2 (HER2) inhibitors for potential use as anticancer agents via ligand-based pharmacophore modeling.
    Zalloum H; Tayyem R; Irmaileh BA; Bustanji Y; Zihlif M; Mohammad M; Rjai TA; Mubarak MS
    J Mol Graph Model; 2015 Sep; 61():61-84. PubMed ID: 26188796
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of Potent Bruton's Tyrosine Kinase Inhibitors Using Ligand Based Modeling.
    Mera WA; Alzihlif M; Taha MO; Khanfar MA
    Anticancer Agents Med Chem; 2017; 17(2):265-275. PubMed ID: 27671297
    [TBL] [Abstract][Full Text] [Related]  

  • 13. In silico drug design of inhibitor of nuclear factor kappa B kinase subunit beta inhibitors from 2-acylamino-3-aminothienopyridines based on quantitative structure-activity relationships and molecular docking.
    Wang JL; Li L; Hu MB; Wu B; Fan WX; Peng W; Wei DN; Wu CJ
    Comput Biol Chem; 2019 Feb; 78():297-305. PubMed ID: 30605855
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques.
    Noha SM; Atanasov AG; Schuster D; Markt P; Fakhrudin N; Heiss EH; Schrammel O; Rollinger JM; Stuppner H; Dirsch VM; Wolber G
    Bioorg Med Chem Lett; 2011 Jan; 21(1):577-83. PubMed ID: 21078555
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation.
    Al-Sha'er MA; Mansi I; Khanfar M; Abudayyh A
    J Enzyme Inhib Med Chem; 2016; 31(sup4):64-77. PubMed ID: 27569779
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of new renin inhibitory leads via sequential pharmacophore modeling, QSAR analysis, in silico screening and in vitro evaluation.
    Al-Nadaf AH; Taha MO
    J Mol Graph Model; 2011 Apr; 29(6):843-64. PubMed ID: 21376648
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of potent NEK2 inhibitors as potential anticancer agents using structure-based exploration of NEK2 pharmacophoric space coupled with QSAR analyses.
    Khanfar MA; Banat F; Alabed S; Alqtaishat S
    Mol Divers; 2017 Feb; 21(1):187-200. PubMed ID: 27599492
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pharmacophore and QSAR modeling of estrogen receptor beta ligands and subsequent validation and in silico search for new hits.
    Taha MO; Tarairah M; Zalloum H; Abu-Sheikha G
    J Mol Graph Model; 2010 Jan; 28(5):383-400. PubMed ID: 19850503
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of new selective cytotoxic agents against Bcl-2 expressing cancer cells using ligand-based modeling.
    Aboalhaija NH; Zihlif MA; Taha MO
    Chem Biol Interact; 2016 Apr; 250():12-26. PubMed ID: 26954606
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Ligand-based modeling of Akt3 lead to potent dual Akt1/Akt3 inhibitor.
    Al-Sha'er MA; Taha MO
    J Mol Graph Model; 2018 Aug; 83():153-166. PubMed ID: 29456101
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.