BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

229 related articles for article (PubMed ID: 28009438)

  • 1. Population pharmacokinetics and exposure-response of osimertinib in patients with non-small cell lung cancer.
    Brown K; Comisar C; Witjes H; Maringwa J; de Greef R; Vishwanathan K; Cantarini M; Cox E
    Br J Clin Pharmacol; 2017 Jun; 83(6):1216-1226. PubMed ID: 28009438
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Effect of Food or Omeprazole on the Pharmacokinetics of Osimertinib in Patients With Non-Small-Cell Lung Cancer and in Healthy Volunteers.
    Vishwanathan K; Dickinson PA; Bui K; Cassier PA; Greystoke A; Lisbon E; Moreno V; So K; Thomas K; Weilert D; Yap TA; Plummer R
    J Clin Pharmacol; 2018 Apr; 58(4):474-484. PubMed ID: 29178442
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Osimertinib for pretreated EGFR Thr790Met-positive advanced non-small-cell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 study.
    Goss G; Tsai CM; Shepherd FA; Bazhenova L; Lee JS; Chang GC; Crino L; Satouchi M; Chu Q; Hida T; Han JY; Juan O; Dunphy F; Nishio M; Kang JH; Majem M; Mann H; Cantarini M; Ghiorghiu S; Mitsudomi T
    Lancet Oncol; 2016 Dec; 17(12):1643-1652. PubMed ID: 27751847
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor.
    Dickinson PA; Cantarini MV; Collier J; Frewer P; Martin S; Pickup K; Ballard P
    Drug Metab Dispos; 2016 Aug; 44(8):1201-12. PubMed ID: 27226351
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Osimertinib for Japanese patients with T790M-positive advanced non-small-cell lung cancer: A pooled subgroup analysis.
    Hirashima T; Satouchi M; Hida T; Nishio M; Kato T; Sakai H; Imamura F; Kiura K; Okamoto I; Kasahara K; Uchida H; Vowler SL; Mitsudomi T
    Cancer Sci; 2019 Sep; 110(9):2884-2893. PubMed ID: 31265163
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Osimertinib Western and Asian clinical pharmacokinetics in patients and healthy volunteers: implications for formulation, dose, and dosing frequency in pivotal clinical studies.
    Planchard D; Brown KH; Kim DW; Kim SW; Ohe Y; Felip E; Leese P; Cantarini M; Vishwanathan K; Jänne PA; Ranson M; Dickinson PA
    Cancer Chemother Pharmacol; 2016 Apr; 77(4):767-76. PubMed ID: 26902828
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Modulation of Fexofenadine Pharmacokinetics by Osimertinib in Patients With Advanced EGFR-Mutated Non-Small Cell Lung Cancer.
    Calvo E; Lee JS; Kim SW; Moreno V; deCastro Carpeno J; Weilert D; Laus G; Mann H; Vishwanathan K
    J Clin Pharmacol; 2019 Aug; 59(8):1099-1109. PubMed ID: 30875094
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Population Pharmacokinetic and Exposure-Response Analysis of Selumetinib and Its N-desmethyl Metabolite in Patients With Non-Small Cell Lung Cancer.
    Tong X; Xu H; Carlile DJ; Tomkinson H; Al-Huniti N; Zhou D
    J Clin Pharmacol; 2019 Jan; 59(1):112-122. PubMed ID: 30102413
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Osimertinib in patients with T790M mutation-positive, advanced non-small cell lung cancer: Long-term follow-up from a pooled analysis of 2 phase 2 studies.
    Ahn MJ; Tsai CM; Shepherd FA; Bazhenova L; Sequist LV; Hida T; Yang JCH; Ramalingam SS; Mitsudomi T; Jänne PA; Mann H; Cantarini M; Goss G
    Cancer; 2019 Mar; 125(6):892-901. PubMed ID: 30512189
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.
    Soria JC; Ohe Y; Vansteenkiste J; Reungwetwattana T; Chewaskulyong B; Lee KH; Dechaphunkul A; Imamura F; Nogami N; Kurata T; Okamoto I; Zhou C; Cho BC; Cheng Y; Cho EK; Voon PJ; Planchard D; Su WC; Gray JE; Lee SM; Hodge R; Marotti M; Rukazenkov Y; Ramalingam SS;
    N Engl J Med; 2018 Jan; 378(2):113-125. PubMed ID: 29151359
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Osimertinib, a third-generation EGFR tyrosine kinase inhibitor: A retrospective multicenter study of its real-world efficacy and safety in advanced/recurrent non-small cell lung carcinoma.
    Kishikawa T; Kasai T; Okada M; Nakachi I; Soda S; Arai R; Takigami A; Sata M
    Thorac Cancer; 2020 Apr; 11(4):935-942. PubMed ID: 32129931
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
    Zhou P; Chen G; Gao M; Wu J
    Bioorg Med Chem; 2018 Dec; 26(23-24):6135-6145. PubMed ID: 30442506
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Efficacy and safety analysis of the German expanded access program of osimertinib in patients with advanced, T790M-positive non-small cell lung cancer.
    Stratmann JA; Michels S; Hornetz S; Christoph DC; Sackmann S; Spengler W; Bischoff H; Schäfer M; Alt J; Müller A; Laack E; Kimmich M; Griesinger F; Sebastian M
    J Cancer Res Clin Oncol; 2018 Dec; 144(12):2457-2463. PubMed ID: 30244389
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity.
    Ballard P; Yates JW; Yang Z; Kim DW; Yang JC; Cantarini M; Pickup K; Jordan A; Hickey M; Grist M; Box M; Johnström P; Varnäs K; Malmquist J; Thress KS; Jänne PA; Cross D
    Clin Cancer Res; 2016 Oct; 22(20):5130-5140. PubMed ID: 27435396
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pharmacokinetic and dose-finding study of osimertinib in patients with impaired renal function and low body weight.
    Fujiwara Y; Makihara R; Hase T; Hashimoto N; Naito T; Tsubata Y; Okuno T; Takahashi T; Kobayashi H; Shinno Y; Zenke Y; Ikeda T; Hosomi Y; Watanabe K; Kitazono S; Sakiyama N; Makino Y; Yamamoto N
    Cancer Sci; 2023 May; 114(5):2087-2097. PubMed ID: 36704833
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A Phase II Trial of Osimertinib in the Second-Line Treatment of Non-small Cell Lung Cancer with the EGFR T790M Mutation, Detected from Circulating Tumor DNA: LiquidLung-O-Cohort 2.
    Park CK; Cho HJ; Choi YD; Oh IJ; Kim YC
    Cancer Res Treat; 2019 Apr; 51(2):777-787. PubMed ID: 30189719
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Osimertinib versus standard-of-care EGFR-TKI as first-line treatment for EGFRm advanced NSCLC: FLAURA Japanese subset.
    Ohe Y; Imamura F; Nogami N; Okamoto I; Kurata T; Kato T; Sugawara S; Ramalingam SS; Uchida H; Hodge R; Vowler SL; Walding A; Nakagawa K
    Jpn J Clin Oncol; 2019 Jan; 49(1):29-36. PubMed ID: 30508196
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Irreversible Inhibition of EGFR: Modeling the Combined Pharmacokinetic-Pharmacodynamic Relationship of Osimertinib and Its Active Metabolite AZ5104.
    Yates JW; Ashton S; Cross D; Mellor MJ; Powell SJ; Ballard P
    Mol Cancer Ther; 2016 Oct; 15(10):2378-2387. PubMed ID: 27439477
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Osimertinib (AZD9291) decreases programmed death ligand-1 in EGFR-mutated non-small cell lung cancer cells.
    Jiang XM; Xu YL; Huang MY; Zhang LL; Su MX; Chen X; Lu JJ
    Acta Pharmacol Sin; 2017 Nov; 38(11):1512-1520. PubMed ID: 28880013
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure-safety relationship in patients with non-small cell lung cancer.
    Lu JF; Eppler SM; Wolf J; Hamilton M; Rakhit A; Bruno R; Lum BL
    Clin Pharmacol Ther; 2006 Aug; 80(2):136-45. PubMed ID: 16890575
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.