BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

225 related articles for article (PubMed ID: 28017939)

  • 1. Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.
    Maiuri T; Mocle AJ; Hung CL; Xia J; van Roon-Mom WM; Truant R
    Hum Mol Genet; 2017 Jan; 26(2):395-406. PubMed ID: 28017939
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates.
    Ferlazzo ML; Sonzogni L; Granzotto A; Bodgi L; Lartin O; Devic C; Vogin G; Pereira S; Foray N
    Mol Neurobiol; 2014 Jun; 49(3):1200-11. PubMed ID: 24277524
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis.
    Ayala-Peña S
    Free Radic Biol Med; 2013 Sep; 62():102-110. PubMed ID: 23602907
    [TBL] [Abstract][Full Text] [Related]  

  • 4. DNA Repair Signaling of Huntingtin: The Next Link Between Late-Onset Neurodegenerative Disease and Oxidative DNA Damage.
    Maiuri T; Bowie LE; Truant R
    DNA Cell Biol; 2019 Jan; 38(1):1-6. PubMed ID: 30481056
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.
    Lu XH; Mattis VB; Wang N; Al-Ramahi I; van den Berg N; Fratantoni SA; Waldvogel H; Greiner E; Osmand A; Elzein K; Xiao J; Dijkstra S; de Pril R; Vinters HV; Faull R; Signer E; Kwak S; Marugan JJ; Botas J; Fischer DF; Svendsen CN; Munoz-Sanjuan I; Yang XW
    Sci Transl Med; 2014 Dec; 6(268):268ra178. PubMed ID: 25540325
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.
    Siddiqui A; Rivera-Sánchez S; Castro Mdel R; Acevedo-Torres K; Rane A; Torres-Ramos CA; Nicholls DG; Andersen JK; Ayala-Torres S
    Free Radic Biol Med; 2012 Oct; 53(7):1478-88. PubMed ID: 22709585
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin.
    Smatlikova P; Askeland G; Vaskovicova M; Klima J; Motlik J; Eide L; Ellederová Z
    Neurodegener Dis; 2019; 19(1):22-34. PubMed ID: 31167196
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Juvenile Huntington's Disease Skin Fibroblasts Respond with Elevated Parkin Level and Increased Proteasome Activity as a Potential Mechanism to Counterbalance the Pathological Consequences of Mutant Huntingtin Protein.
    Aladdin A; Király R; Boto P; Regdon Z; Tar K
    Int J Mol Sci; 2019 Oct; 20(21):. PubMed ID: 31717806
    [TBL] [Abstract][Full Text] [Related]  

  • 9. DNA Damage Repair in Huntington's Disease and Other Neurodegenerative Diseases.
    Maiuri T; Suart CE; Hung CLK; Graham KJ; Barba Bazan CA; Truant R
    Neurotherapeutics; 2019 Oct; 16(4):948-956. PubMed ID: 31364066
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A patient-derived cellular model for Huntington's disease reveals phenotypes at clinically relevant CAG lengths.
    Hung CL; Maiuri T; Bowie LE; Gotesman R; Son S; Falcone M; Giordano JV; Gillis T; Mattis V; Lau T; Kwan V; Wheeler V; Schertzer J; Singh K; Truant R
    Mol Biol Cell; 2018 Nov; 29(23):2809-2820. PubMed ID: 30256717
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization.
    DiGiovanni LF; Mocle AJ; Xia J; Truant R
    Hum Mol Genet; 2016 Sep; 25(18):3937-3945. PubMed ID: 27466181
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease.
    Tidball AM; Bryan MR; Uhouse MA; Kumar KK; Aboud AA; Feist JE; Ess KC; Neely MD; Aschner M; Bowman AB
    Hum Mol Genet; 2015 Apr; 24(7):1929-44. PubMed ID: 25489053
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Exploring the role of high-mobility group box 1 (HMGB1) protein in the pathogenesis of Huntington's disease.
    Angelopoulou E; Paudel YN; Piperi C
    J Mol Med (Berl); 2020 Mar; 98(3):325-334. PubMed ID: 32036391
    [TBL] [Abstract][Full Text] [Related]  

  • 14. PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.
    Morozko EL; Smith-Geater C; Monteys AM; Pradhan S; Lim RG; Langfelder P; Kachemov M; Kulkarni JA; Zaifman J; Hill A; Stocksdale JT; Cullis PR; Wu J; Ochaba J; Miramontes R; Chakraborty A; Hazra TK; Lau A; St-Cyr S; Orellana I; Kopan L; Wang KQ; Yeung S; Leavitt BR; Reidling JC; Yang XW; Steffan JS; Davidson BL; Sarkar PS; Thompson LM
    Proc Natl Acad Sci U S A; 2021 Jan; 118(4):. PubMed ID: 33468657
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient.
    Chae JI; Kim DW; Lee N; Jeon YJ; Jeon I; Kwon J; Kim J; Soh Y; Lee DS; Seo KS; Choi NJ; Park BC; Kang SH; Ryu J; Oh SH; Shin DA; Lee DR; Do JT; Park IH; Daley GQ; Song J
    Biochem J; 2012 Sep; 446(3):359-71. PubMed ID: 22694310
    [TBL] [Abstract][Full Text] [Related]  

  • 16. High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry.
    Son S; Bowie LE; Maiuri T; Hung CLK; Desmond CR; Xia J; Truant R
    J Biol Chem; 2019 Feb; 294(6):1915-1923. PubMed ID: 30538129
    [TBL] [Abstract][Full Text] [Related]  

  • 17. DNA damage induced by polyglutamine-expanded proteins.
    Giuliano P; De Cristofaro T; Affaitati A; Pizzulo GM; Feliciello A; Criscuolo C; De Michele G; Filla A; Avvedimento EV; Varrone S
    Hum Mol Genet; 2003 Sep; 12(18):2301-9. PubMed ID: 12915485
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses.
    Kobayashi J; Saito Y; Okui M; Miwa N; Komatsu K
    Mutat Res Genet Toxicol Environ Mutagen; 2015 Apr; 782():42-50. PubMed ID: 25868131
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A toxic mutant huntingtin species is resistant to selective autophagy.
    Fu Y; Wu P; Pan Y; Sun X; Yang H; Difiglia M; Lu B
    Nat Chem Biol; 2017 Nov; 13(11):1152-1154. PubMed ID: 28869595
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.
    Gao R; Chakraborty A; Geater C; Pradhan S; Gordon KL; Snowden J; Yuan S; Dickey AS; Choudhary S; Ashizawa T; Ellerby LM; La Spada AR; Thompson LM; Hazra TK; Sarkar PS
    Elife; 2019 Apr; 8():. PubMed ID: 30994454
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.