BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

327 related articles for article (PubMed ID: 28042336)

  • 1. Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor.
    Hultqvist G; Syvänen S; Fang XT; Lannfelt L; Sehlin D
    Theranostics; 2017; 7(2):308-318. PubMed ID: 28042336
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging.
    Syvänen S; Fang XT; Hultqvist G; Meier SR; Lannfelt L; Sehlin D
    Neuroimage; 2017 Mar; 148():55-63. PubMed ID: 28069541
    [TBL] [Abstract][Full Text] [Related]  

  • 3. High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain.
    Fang XT; Hultqvist G; Meier SR; Antoni G; Sehlin D; Syvänen S
    Neuroimage; 2019 Jan; 184():881-888. PubMed ID: 30300753
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody.
    Syvänen S; Hultqvist G; Gustavsson T; Gumucio A; Laudon H; Söderberg L; Ingelsson M; Lannfelt L; Sehlin D
    Alzheimers Res Ther; 2018 May; 10(1):49. PubMed ID: 29793530
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.
    Niewoehner J; Bohrmann B; Collin L; Urich E; Sade H; Maier P; Rueger P; Stracke JO; Lau W; Tissot AC; Loetscher H; Ghosh A; Freskgård PO
    Neuron; 2014 Jan; 81(1):49-60. PubMed ID: 24411731
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Blood-Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer's Disease.
    Chang R; Knox J; Chang J; Derbedrossian A; Vasilevko V; Cribbs D; Boado RJ; Pardridge WM; Sumbria RK
    Mol Pharm; 2017 Jul; 14(7):2340-2349. PubMed ID: 28514851
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood-brain barrier in vitro is dependent on its binding affinity.
    Haqqani AS; Thom G; Burrell M; Delaney CE; Brunette E; Baumann E; Sodja C; Jezierski A; Webster C; Stanimirovic DB
    J Neurochem; 2018 Sep; 146(6):735-752. PubMed ID: 29877588
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Transferrin Receptor-Mediated Uptake at the Blood-Brain Barrier Is Not Impaired by Alzheimer's Disease Neuropathology.
    Bourassa P; Alata W; Tremblay C; Paris-Robidas S; Calon F
    Mol Pharm; 2019 Feb; 16(2):583-594. PubMed ID: 30609376
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse.
    Boado RJ; Zhang Y; Wang Y; Pardridge WM
    Biotechnol Bioeng; 2009 Mar; 102(4):1251-8. PubMed ID: 18942151
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β.
    Sehlin D; Fang XT; Meier SR; Jansson M; Syvänen S
    Sci Rep; 2017 Dec; 7(1):17254. PubMed ID: 29222502
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Receptor-mediated abeta amyloid antibody targeting to Alzheimer's disease mouse brain.
    Zhou QH; Fu A; Boado RJ; Hui EK; Lu JZ; Pardridge WM
    Mol Pharm; 2011 Feb; 8(1):280-5. PubMed ID: 21141969
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Study of the transcytosis of an anti-transferrin receptor antibody with a Fab' cargo across the blood-brain barrier in mice.
    Manich G; Cabezón I; del Valle J; Duran-Vilaregut J; Camins A; Pallàs M; Pelegrí C; Vilaplana J
    Eur J Pharm Sci; 2013 Jul; 49(4):556-64. PubMed ID: 23748097
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
    Sehlin D; Stocki P; Gustavsson T; Hultqvist G; Walsh FS; Rutkowski JL; Syvänen S
    FASEB J; 2020 Oct; 34(10):13272-13283. PubMed ID: 32779267
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody.
    Faresjö R; Sehlin D; Syvänen S
    Fluids Barriers CNS; 2023 May; 20(1):34. PubMed ID: 37170266
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody.
    Schlein E; Andersson KG; Dallas T; Syvänen S; Sehlin D
    MAbs; 2024; 16(1):2339337. PubMed ID: 38634473
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.
    Yu YJ; Zhang Y; Kenrick M; Hoyte K; Luk W; Lu Y; Atwal J; Elliott JM; Prabhu S; Watts RJ; Dennis MS
    Sci Transl Med; 2011 May; 3(84):84ra44. PubMed ID: 21613623
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses.
    Morrison JI; Metzendorf NG; Rofo F; Petrovic A; Hultqvist G
    J Neurochem; 2023 May; 165(3):413-425. PubMed ID: 36681883
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.
    Yu YJ; Atwal JK; Zhang Y; Tong RK; Wildsmith KR; Tan C; Bien-Ly N; Hersom M; Maloney JA; Meilandt WJ; Bumbaca D; Gadkar K; Hoyte K; Luk W; Lu Y; Ernst JA; Scearce-Levie K; Couch JA; Dennis MS; Watts RJ
    Sci Transl Med; 2014 Nov; 6(261):261ra154. PubMed ID: 25378646
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies.
    Bien-Ly N; Boswell CA; Jeet S; Beach TG; Hoyte K; Luk W; Shihadeh V; Ulufatu S; Foreman O; Lu Y; DeVoss J; van der Brug M; Watts RJ
    Neuron; 2015 Oct; 88(2):289-97. PubMed ID: 26494278
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease.
    Gustavsson T; Metzendorf NG; Wik E; Roshanbin S; Julku U; Chourlia A; Nilsson P; Andersson KG; Laudon H; Hultqvist G; Syvänen S; Sehlin D
    Alzheimers Res Ther; 2023 May; 15(1):90. PubMed ID: 37131196
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.