These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

423 related articles for article (PubMed ID: 28049728)

  • 1. Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide.
    Hatami A; Monjazeb S; Milton S; Glabe CG
    J Biol Chem; 2017 Feb; 292(8):3172-3185. PubMed ID: 28049728
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues.
    Devkota S; Williams TD; Wolfe MS
    J Biol Chem; 2021; 296():100281. PubMed ID: 33450230
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dual effects of familial Alzheimer's disease mutations (D7H, D7N, and H6R) on amyloid β peptide: correlation dynamics and zinc binding.
    Xu L; Chen Y; Wang X
    Proteins; 2014 Dec; 82(12):3286-97. PubMed ID: 25137638
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Regulation of Alzheimer beta-amyloid precursor trafficking and metabolism.
    Gandy S; Petanceska S
    Biochim Biophys Acta; 2000 Jul; 1502(1):44-52. PubMed ID: 10899430
    [TBL] [Abstract][Full Text] [Related]  

  • 5. AMY plaques in familial AD: comparison with sporadic Alzheimer's disease.
    Lippa CF; Schmidt ML; Nee LE; Bird T; Nochlin D; Hulette C; Mori H; Lee VM; Trojanowski JQ
    Neurology; 2000 Jan; 54(1):100-4. PubMed ID: 10636133
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease.
    Rasmussen J; Mahler J; Beschorner N; Kaeser SA; Häsler LM; Baumann F; Nyström S; Portelius E; Blennow K; Lashley T; Fox NC; Sepulveda-Falla D; Glatzel M; Oblak AL; Ghetti B; Nilsson KPR; Hammarström P; Staufenbiel M; Walker LC; Jucker M
    Proc Natl Acad Sci U S A; 2017 Dec; 114(49):13018-13023. PubMed ID: 29158413
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H; Capell A; Leimer U; Haass C
    Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In search of pathogenic amyloid β-peptide in familial Alzheimer's disease.
    Wolfe MS
    Prog Mol Biol Transl Sci; 2019; 168():71-78. PubMed ID: 31699328
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Familial Alzheimer's disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system.
    Tackenberg C; Kulic L; Nitsch RM
    PLoS One; 2020; 15(9):e0239584. PubMed ID: 32966331
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.
    Condello C; Lemmin T; Stöhr J; Nick M; Wu Y; Maxwell AM; Watts JC; Caro CD; Oehler A; Keene CD; Bird TD; van Duinen SG; Lannfelt L; Ingelsson M; Graff C; Giles K; DeGrado WF; Prusiner SB
    Proc Natl Acad Sci U S A; 2018 Jan; 115(4):E782-E791. PubMed ID: 29311311
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.
    Jang H; Arce FT; Ramachandran S; Kagan BL; Lal R; Nussinov R
    J Phys Chem B; 2013 Oct; 117(39):11518-29. PubMed ID: 24000923
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP.
    Klementieva O; Willén K; Martinsson I; Israelsson B; Engdahl A; Cladera J; Uvdal P; Gouras GK
    Nat Commun; 2017 Mar; 8():14726. PubMed ID: 28287086
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The Osaka FAD mutation E22Δ leads to the formation of a previously unknown type of amyloid β fibrils and modulates Aβ neurotoxicity.
    Ovchinnikova OY; Finder VH; Vodopivec I; Nitsch RM; Glockshuber R
    J Mol Biol; 2011 May; 408(4):780-91. PubMed ID: 21402079
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The gene defects responsible for familial Alzheimer's disease.
    Tanzi RE; Kovacs DM; Kim TW; Moir RD; Guenette SY; Wasco W
    Neurobiol Dis; 1996; 3(3):159-68. PubMed ID: 8980016
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations.
    Seuma M; Faure AJ; Badia M; Lehner B; Bolognesi B
    Elife; 2021 Feb; 10():. PubMed ID: 33522485
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
    Shimojo M; Sahara N; Mizoroki T; Funamoto S; Morishima-Kawashima M; Kudo T; Takeda M; Ihara Y; Ichinose H; Takashima A
    J Biol Chem; 2008 Jun; 283(24):16488-96. PubMed ID: 18430735
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Segregation of a missense mutation in the amyloid beta-protein precursor gene with familial Alzheimer's disease.
    Goate A
    J Alzheimers Dis; 2006; 9(3 Suppl):341-7. PubMed ID: 16914872
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.
    Ochalek A; Mihalik B; Avci HX; Chandrasekaran A; Téglási A; Bock I; Giudice ML; Táncos Z; Molnár K; László L; Nielsen JE; Holst B; Freude K; Hyttel P; Kobolák J; Dinnyés A
    Alzheimers Res Ther; 2017 Dec; 9(1):90. PubMed ID: 29191219
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.
    Kwart D; Gregg A; Scheckel C; Murphy EA; Paquet D; Duffield M; Fak J; Olsen O; Darnell RB; Tessier-Lavigne M
    Neuron; 2019 Oct; 104(2):256-270.e5. PubMed ID: 31416668
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology.
    Pahrudin Arrozi A; Shukri SNS; Wan Ngah WZ; Mohd Yusof YA; Ahmad Damanhuri MH; Makpol S
    Appl Biochem Biotechnol; 2017 Nov; 183(3):853-866. PubMed ID: 28417423
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 22.