419 related articles for article (PubMed ID: 28049728)
1. Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide.
Hatami A; Monjazeb S; Milton S; Glabe CG
J Biol Chem; 2017 Feb; 292(8):3172-3185. PubMed ID: 28049728
[TBL] [Abstract][Full Text] [Related]
2. Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues.
Devkota S; Williams TD; Wolfe MS
J Biol Chem; 2021; 296():100281. PubMed ID: 33450230
[TBL] [Abstract][Full Text] [Related]
3. Dual effects of familial Alzheimer's disease mutations (D7H, D7N, and H6R) on amyloid β peptide: correlation dynamics and zinc binding.
Xu L; Chen Y; Wang X
Proteins; 2014 Dec; 82(12):3286-97. PubMed ID: 25137638
[TBL] [Abstract][Full Text] [Related]
4. Regulation of Alzheimer beta-amyloid precursor trafficking and metabolism.
Gandy S; Petanceska S
Biochim Biophys Acta; 2000 Jul; 1502(1):44-52. PubMed ID: 10899430
[TBL] [Abstract][Full Text] [Related]
5. AMY plaques in familial AD: comparison with sporadic Alzheimer's disease.
Lippa CF; Schmidt ML; Nee LE; Bird T; Nochlin D; Hulette C; Mori H; Lee VM; Trojanowski JQ
Neurology; 2000 Jan; 54(1):100-4. PubMed ID: 10636133
[TBL] [Abstract][Full Text] [Related]
6. Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease.
Rasmussen J; Mahler J; Beschorner N; Kaeser SA; Häsler LM; Baumann F; Nyström S; Portelius E; Blennow K; Lashley T; Fox NC; Sepulveda-Falla D; Glatzel M; Oblak AL; Ghetti B; Nilsson KPR; Hammarström P; Staufenbiel M; Walker LC; Jucker M
Proc Natl Acad Sci U S A; 2017 Dec; 114(49):13018-13023. PubMed ID: 29158413
[TBL] [Abstract][Full Text] [Related]
7. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
8. In search of pathogenic amyloid β-peptide in familial Alzheimer's disease.
Wolfe MS
Prog Mol Biol Transl Sci; 2019; 168():71-78. PubMed ID: 31699328
[TBL] [Abstract][Full Text] [Related]
9. Familial Alzheimer's disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system.
Tackenberg C; Kulic L; Nitsch RM
PLoS One; 2020; 15(9):e0239584. PubMed ID: 32966331
[TBL] [Abstract][Full Text] [Related]
10. Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.
Condello C; Lemmin T; Stöhr J; Nick M; Wu Y; Maxwell AM; Watts JC; Caro CD; Oehler A; Keene CD; Bird TD; van Duinen SG; Lannfelt L; Ingelsson M; Graff C; Giles K; DeGrado WF; Prusiner SB
Proc Natl Acad Sci U S A; 2018 Jan; 115(4):E782-E791. PubMed ID: 29311311
[TBL] [Abstract][Full Text] [Related]
11. Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.
Jang H; Arce FT; Ramachandran S; Kagan BL; Lal R; Nussinov R
J Phys Chem B; 2013 Oct; 117(39):11518-29. PubMed ID: 24000923
[TBL] [Abstract][Full Text] [Related]
12. Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP.
Klementieva O; Willén K; Martinsson I; Israelsson B; Engdahl A; Cladera J; Uvdal P; Gouras GK
Nat Commun; 2017 Mar; 8():14726. PubMed ID: 28287086
[TBL] [Abstract][Full Text] [Related]
13. The Osaka FAD mutation E22Δ leads to the formation of a previously unknown type of amyloid β fibrils and modulates Aβ neurotoxicity.
Ovchinnikova OY; Finder VH; Vodopivec I; Nitsch RM; Glockshuber R
J Mol Biol; 2011 May; 408(4):780-91. PubMed ID: 21402079
[TBL] [Abstract][Full Text] [Related]
14. The gene defects responsible for familial Alzheimer's disease.
Tanzi RE; Kovacs DM; Kim TW; Moir RD; Guenette SY; Wasco W
Neurobiol Dis; 1996; 3(3):159-68. PubMed ID: 8980016
[TBL] [Abstract][Full Text] [Related]
15. Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
Shimojo M; Sahara N; Mizoroki T; Funamoto S; Morishima-Kawashima M; Kudo T; Takeda M; Ihara Y; Ichinose H; Takashima A
J Biol Chem; 2008 Jun; 283(24):16488-96. PubMed ID: 18430735
[TBL] [Abstract][Full Text] [Related]
16. Segregation of a missense mutation in the amyloid beta-protein precursor gene with familial Alzheimer's disease.
Goate A
J Alzheimers Dis; 2006; 9(3 Suppl):341-7. PubMed ID: 16914872
[TBL] [Abstract][Full Text] [Related]
17. The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations.
Seuma M; Faure AJ; Badia M; Lehner B; Bolognesi B
Elife; 2021 Feb; 10():. PubMed ID: 33522485
[TBL] [Abstract][Full Text] [Related]
18. Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.
Ochalek A; Mihalik B; Avci HX; Chandrasekaran A; Téglási A; Bock I; Giudice ML; Táncos Z; Molnár K; László L; Nielsen JE; Holst B; Freude K; Hyttel P; Kobolák J; Dinnyés A
Alzheimers Res Ther; 2017 Dec; 9(1):90. PubMed ID: 29191219
[TBL] [Abstract][Full Text] [Related]
19. A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.
Kwart D; Gregg A; Scheckel C; Murphy EA; Paquet D; Duffield M; Fak J; Olsen O; Darnell RB; Tessier-Lavigne M
Neuron; 2019 Oct; 104(2):256-270.e5. PubMed ID: 31416668
[TBL] [Abstract][Full Text] [Related]
20. Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology.
Pahrudin Arrozi A; Shukri SNS; Wan Ngah WZ; Mohd Yusof YA; Ahmad Damanhuri MH; Makpol S
Appl Biochem Biotechnol; 2017 Nov; 183(3):853-866. PubMed ID: 28417423
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]