These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

145 related articles for article (PubMed ID: 28074893)

  • 1. Understanding the molecular mechanism for the differential inhibitory activities of compounds against MTH1.
    Wang M; Zhou S; Chen Q; Wang L; Liang Z; Wang J
    Sci Rep; 2017 Jan; 7():40557. PubMed ID: 28074893
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The influence of residue in the position of 116 on the inhibitory potency of TH588 for MTH1.
    Niu RJ; Zheng QC; Zhang HX
    J Mol Graph Model; 2018 Oct; 85():75-83. PubMed ID: 30103119
    [TBL] [Abstract][Full Text] [Related]  

  • 3. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
    Gad H; Koolmeister T; Jemth AS; Eshtad S; Jacques SA; Ström CE; Svensson LM; Schultz N; Lundbäck T; Einarsdottir BO; Saleh A; Göktürk C; Baranczewski P; Svensson R; Berntsson RP; Gustafsson R; Strömberg K; Sanjiv K; Jacques-Cordonnier MC; Desroses M; Gustavsson AL; Olofsson R; Johansson F; Homan EJ; Loseva O; Bräutigam L; Johansson L; Höglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KS; Wallner OA; Hammarström LG; Wiita E; Almlöf I; Kalderén C; Axelsson H; Djureinovic T; Puigvert JC; Häggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
    Nature; 2014 Apr; 508(7495):215-21. PubMed ID: 24695224
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia.
    Pompsch M; Vogel J; Classen F; Kranz P; Iliakis G; Riffkin H; Brockmeier U; Metzen E
    BMC Cancer; 2018 Nov; 18(1):1190. PubMed ID: 30497423
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1.
    Chen H; Afrin S; Guo Y; Chu W; Benzinger TLS; Rogers BE; Garbow JR; Perlmutter JS; Zhou D; Xu J
    Int J Mol Sci; 2020 Nov; 21(22):. PubMed ID: 33238630
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In silico prediction of new inhibitors for the nucleotide pool sanitizing enzyme, MTH1, using drug repurposing.
    Sohraby F; Bagheri M; Javaheri Moghadam M; Aryapour H
    J Biomol Struct Dyn; 2018 Aug; 36(10):2628-2636. PubMed ID: 28818011
    [No Abstract]   [Full Text] [Related]  

  • 7. Crystal structure of human MTH1 and the 8-oxo-dGMP product complex.
    Svensson LM; Jemth AS; Desroses M; Loseva O; Helleday T; Högbom M; Stenmark P
    FEBS Lett; 2011 Aug; 585(16):2617-21. PubMed ID: 21787772
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synergistic therapy of chemotherapeutic drugs and MTH1 inhibitors using a pH-sensitive polymeric delivery system for oral squamous cell carcinoma.
    Li X; Li L; Huang Y; Liu B; Chi H; Shi L; Zhang W; Li G; Niu Y; Zhu X
    Biomater Sci; 2017 Sep; 5(10):2068-2078. PubMed ID: 28744533
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
    Narwal M; Jemth AS; Gustafsson R; Almlöf I; Warpman Berglund U; Helleday T; Stenmark P
    Biochemistry; 2018 Feb; 57(5):593-603. PubMed ID: 29281266
    [TBL] [Abstract][Full Text] [Related]  

  • 10. MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
    Zhan D; Zhang X; Li J; Ding X; Cui Y; Jia J
    Cancer Biother Radiopharm; 2020 Apr; 35(3):223-232. PubMed ID: 32077746
    [No Abstract]   [Full Text] [Related]  

  • 11. Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.
    Kawamura T; Kawatani M; Muroi M; Kondoh Y; Futamura Y; Aono H; Tanaka M; Honda K; Osada H
    Sci Rep; 2016 May; 6():26521. PubMed ID: 27210421
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Delivery of MTH1 inhibitor (TH287) and MDR1 siRNA via hyaluronic acid-based mesoporous silica nanoparticles for oral cancers treatment.
    Shi XL; Li Y; Zhao LM; Su LW; Ding G
    Colloids Surf B Biointerfaces; 2019 Jan; 173():599-606. PubMed ID: 30352381
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures.
    van der Waals LM; Laoukili J; Jongen JMJ; Raats DA; Borel Rinkes IHM; Kranenburg O
    Sci Rep; 2019 Jan; 9(1):819. PubMed ID: 30692572
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells.
    Aristizabal Prada ET; Orth M; Nölting S; Spöttl G; Maurer J; Auernhammer C
    PLoS One; 2017; 12(5):e0178375. PubMed ID: 28542590
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma.
    Saleh A; Gökturk C; Warpman-Berglund U; Helleday T; Granelli I
    J Pharm Biomed Anal; 2015 Feb; 104():1-11. PubMed ID: 25459754
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A comparison of X-ray and calculated structures of the enzyme MTH1.
    Ryan H; Carter M; Stenmark P; Stewart JJ; Braun-Sand SB
    J Mol Model; 2016 Jul; 22(7):168. PubMed ID: 27350386
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.
    Peng C; Li YH; Yu CW; Cheng ZH; Liu JR; Hsu JL; Hsin LW; Huang CT; Juan HF; Chern JW; Cheng YS
    Bioorg Chem; 2021 May; 110():104813. PubMed ID: 33774493
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Development of MTH1-Binding Nucleotide Analogs Based on 7,8-Dihalogenated 7-Deaza-dG Derivatives.
    Shi H; Ishikawa R; Heh CH; Sasaki S; Taniguchi Y
    Int J Mol Sci; 2021 Jan; 22(3):. PubMed ID: 33525366
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors.
    Kumar A; Kawamura T; Kawatani M; Osada H; Zhang KYJ
    Chem Biol Drug Des; 2017 Jun; 89(6):862-869. PubMed ID: 27863017
    [TBL] [Abstract][Full Text] [Related]  

  • 20. [Proliferation-Inhibitory and Apoptosis-Inducing Effects of Targeting MTH1 on Multiple Myeloma Cells].
    Wang X; Wu Y; Zhang L; Li YX; Han B; Shi X; Wang W; Wang LS
    Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2020 Oct; 28(5):1598-1604. PubMed ID: 33067960
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.