BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

290 related articles for article (PubMed ID: 28086830)

  • 1. Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.
    Pati ML; Hornick JR; Niso M; Berardi F; Spitzer D; Abate C; Hawkins W
    BMC Cancer; 2017 Jan; 17(1):51. PubMed ID: 28086830
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.
    Hornick JR; Vangveravong S; Spitzer D; Abate C; Berardi F; Goedegebuure P; Mach RH; Hawkins WG
    J Exp Clin Cancer Res; 2012 May; 31(1):41. PubMed ID: 22551149
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy.
    Kashiwagi H; McDunn JE; Simon PO; Goedegebuure PS; Xu J; Jones L; Chang K; Johnston F; Trinkaus K; Hotchkiss RS; Mach RH; Hawkins WG
    Mol Cancer; 2007 Jul; 6():48. PubMed ID: 17631687
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models.
    Niso M; Kopecka J; Abatematteo FS; Berardi F; Riganti C; Abate C
    Cell Oncol (Dordr); 2021 Dec; 44(6):1307-1323. PubMed ID: 34586588
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.
    Abate C; Hornick JR; Spitzer D; Hawkins WG; Niso M; Perrone R; Berardi F
    J Med Chem; 2011 Aug; 54(16):5858-67. PubMed ID: 21744858
    [TBL] [Abstract][Full Text] [Related]  

  • 6. F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells.
    Cassano G; Gasparre G; Niso M; Contino M; Scalera V; Colabufo NA
    Cell Calcium; 2009 Apr; 45(4):340-5. PubMed ID: 19187959
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor.
    Liu CC; Yu CF; Wang SC; Li HY; Lin CM; Wang HH; Abate C; Chiang CS
    BMC Cancer; 2019 May; 19(1):473. PubMed ID: 31109310
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).
    Berardi F; Abate C; Ferorelli S; Uricchio V; Colabufo NA; Niso M; Perrone R
    J Med Chem; 2009 Dec; 52(23):7817-28. PubMed ID: 19842660
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer.
    Azzariti A; Colabufo NA; Berardi F; Porcelli L; Niso M; Simone GM; Perrone R; Paradiso A
    Mol Cancer Ther; 2006 Jul; 5(7):1807-16. PubMed ID: 16891467
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic.
    Ohman KA; Hashim YM; Vangveravong S; Nywening TM; Cullinan DR; Goedegebuure SP; Liu J; Van Tine BA; Tiriac H; Tuveson DA; DeNardo DG; Spitzer D; Mach RH; Hawkins WG
    Oncotarget; 2016 Jun; 7(23):33529-41. PubMed ID: 27244881
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and pharmacological evaluation of ¹¹C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging.
    Selivanova SV; Toscano A; Abate C; Berardi F; Müller A; Krämer SD; Schibli R; Ametamey SM
    Nucl Med Biol; 2015 Apr; 42(4):399-405. PubMed ID: 25637276
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and σ receptors binding properties.
    Abate C; Niso M; Marottoli R; Riganti C; Ghigo D; Ferorelli S; Ossato G; Perrone R; Lacivita E; Lamb DC; Berardi F
    J Med Chem; 2014 Apr; 57(8):3314-23. PubMed ID: 24697311
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 2-Aminopyridine derivatives as potential σ(2) receptor antagonists.
    Abate C; Ferorelli S; Niso M; Lovicario C; Infantino V; Convertini P; Perrone R; Berardi F
    ChemMedChem; 2012 Oct; 7(10):1847-57. PubMed ID: 22890883
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine.
    Hornick JR; Xu J; Vangveravong S; Tu Z; Mitchem JB; Spitzer D; Goedegebuure P; Mach RH; Hawkins WG
    Mol Cancer; 2010 Nov; 9():298. PubMed ID: 21092190
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Capsaicin induces cytotoxicity in pancreatic neuroendocrine tumor cells via mitochondrial action.
    Skrzypski M; Sassek M; Abdelmessih S; Mergler S; Grötzinger C; Metzke D; Wojciechowicz T; Nowak KW; Strowski MZ
    Cell Signal; 2014 Jan; 26(1):41-8. PubMed ID: 24075930
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A novel colchicine-based microtubule inhibitor exhibits potent antitumor activity by inducing mitochondrial mediated apoptosis in MIA PaCa-2 pancreatic cancer cells.
    Kumar A; Singh B; Mahajan G; Sharma PR; Bharate SB; Mintoo MJ; Mondhe DM
    Tumour Biol; 2016 Oct; 37(10):13121-13136. PubMed ID: 27449046
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tumor apoptosis induced by epoxide-containing piperazines, a new class of anti-cancer agents.
    Eilon GF; Gu J; Slater LM; Hara K; Jacobs JW
    Cancer Chemother Pharmacol; 2000; 45(3):183-91. PubMed ID: 10663635
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cytotoxic activities of hydroxyethyl piperazine-based σ receptor ligands on cancer cells alone and in combination with melphalan, PB28 and haloperidol.
    Korpis K; Weber F; Wünsch B; Bednarski PJ
    Pharmazie; 2014 Dec; 69(12):917-22. PubMed ID: 25951666
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells.
    Kasukabe T; Honma Y; Okabe-Kado J; Higuchi Y; Kato N; Kumakura S
    Oncol Rep; 2016 Aug; 36(2):968-76. PubMed ID: 27375275
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Genistein induced anticancer effects on pancreatic cancer cell lines involves mitochondrial apoptosis, G
    Bi YL; Min M; Shen W; Liu Y
    Phytomedicine; 2018 Jan; 39():10-16. PubMed ID: 29433670
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.