BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

264 related articles for article (PubMed ID: 28091608)

  • 1. Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors.
    Jakubík J; Randáková A; Zimčík P; El-Fakahany EE; Doležal V
    Sci Rep; 2017 Jan; 7():40381. PubMed ID: 28091608
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors.
    Voigtländer U; Jöhren K; Mohr M; Raasch A; Tränkle C; Buller S; Ellis J; Höltje HD; Mohr K
    Mol Pharmacol; 2003 Jul; 64(1):21-31. PubMed ID: 12815157
    [TBL] [Abstract][Full Text] [Related]  

  • 3. New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo.
    Schrage R; Holze J; Klöckner J; Balkow A; Klause AS; Schmitz AL; De Amici M; Kostenis E; Tränkle C; Holzgrabe U; Mohr K
    Biochem Pharmacol; 2014 Aug; 90(3):307-19. PubMed ID: 24863257
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
    Tränkle C; Weyand O; Voigtländer U; Mynett A; Lazareno S; Birdsall NJ; Mohr K
    Mol Pharmacol; 2003 Jul; 64(1):180-90. PubMed ID: 12815174
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Modes of allosteric interactions with free and [3H]N-methylscopolamine-occupied muscarinic M2 receptors as deduced from buffer-dependent potency shifts.
    Schröter A; Tränkle C; Mohr K
    Naunyn Schmiedebergs Arch Pharmacol; 2000 Dec; 362(6):512-9. PubMed ID: 11138843
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors.
    Jakubík J; Bacáková L; el-Fakahany EE; Tucek S
    J Pharmacol Exp Ther; 1995 Sep; 274(3):1077-83. PubMed ID: 7562472
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity.
    Prilla S; Schrobang J; Ellis J; Höltje HD; Mohr K
    Mol Pharmacol; 2006 Jul; 70(1):181-93. PubMed ID: 16641315
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evidence for a tandem two-site model of ligand binding to muscarinic acetylcholine receptors.
    Jakubik J; El-Fakahany EE; Tucek S
    J Biol Chem; 2000 Jun; 275(25):18836-44. PubMed ID: 10749854
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor.
    Steinfeld T; Mammen M; Smith JA; Wilson RD; Jasper JR
    Mol Pharmacol; 2007 Aug; 72(2):291-302. PubMed ID: 17478612
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors.
    Lazareno S; Birdsall B; Fukazawa T; Gharagozloo P; Hashimoto T; Kuwano H; Popham A; Sugimoto M; Birdsall NJ
    Life Sci; 1999; 64(6-7):519-26. PubMed ID: 10069518
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of novel and functionally selective non-competitive muscarinic antagonists as chemical probes.
    Boulos JF; Jakubik J; Boulos JM; Randakova A; Momirov J
    Chem Biol Drug Des; 2018 Jan; 91(1):93-104. PubMed ID: 28646631
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Allosteric modulation by persistent binding of xanomeline of the interaction of competitive ligands with the M1 muscarinic acetylcholine receptor.
    Jakubík J; Tucek S; El-Fakahany EE
    J Pharmacol Exp Ther; 2002 Jun; 301(3):1033-41. PubMed ID: 12023535
    [TBL] [Abstract][Full Text] [Related]  

  • 13. M2 Subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: Effect of chemical homo-dimerization on orthosteric (and allosteric?) binding.
    Keller M; Tränkle C; She X; Pegoli A; Bernhardt G; Buschauer A; Read RW
    Bioorg Med Chem; 2015 Jul; 23(14):3970-90. PubMed ID: 25650309
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site.
    Lazareno S; Popham A; Birdsall NJ
    Mol Pharmacol; 2000 Jul; 58(1):194-207. PubMed ID: 10860942
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors.
    Lanzafame AA; Sexton PM; Christopoulos A
    Mol Pharmacol; 2006 Aug; 70(2):736-46. PubMed ID: 16709648
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites.
    Schober DA; Croy CH; Xiao H; Christopoulos A; Felder CC
    Mol Pharmacol; 2014 Jul; 86(1):116-23. PubMed ID: 24807966
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Changes of cooperativity between N-methylscopolamine and allosteric modulators alcuronium and gallamine induced by mutations of external loops of muscarinic M(3) receptors.
    Krejcí A; Tucek S
    Mol Pharmacol; 2001 Oct; 60(4):761-7. PubMed ID: 11562438
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular mechanisms of methoctramine binding and selectivity at muscarinic acetylcholine receptors.
    Jakubík J; Zimčík P; Randáková A; Fuksová K; El-Fakahany EE; Doležal V
    Mol Pharmacol; 2014 Aug; 86(2):180-92. PubMed ID: 24870405
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Complex allosteric modulation of cardiac muscarinic receptors by protamine: potential model for putative endogenous ligands.
    Hu J; Wang SZ; Forray C; el-Fakahany EE
    Mol Pharmacol; 1992 Aug; 42(2):311-21. PubMed ID: 1513329
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Influence of ligand choice on the apparent binding profile of gallamine to cardiac muscarinic receptors. Identification of three main types of gallamine-muscarinic receptor interactions.
    Lee NH; el-Fakahany EE
    J Pharmacol Exp Ther; 1988 Sep; 246(3):829-38. PubMed ID: 3418516
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.