215 related articles for article (PubMed ID: 28100566)
1. Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.
Picco G; Petti C; Centonze A; Torchiaro E; Crisafulli G; Novara L; Acquaviva A; Bardelli A; Medico E
EMBO Mol Med; 2017 Mar; 9(3):293-303. PubMed ID: 28100566
[TBL] [Abstract][Full Text] [Related]
2. Comprehensive characterization of RSPO fusions in colorectal traditional serrated adenomas.
Sekine S; Ogawa R; Hashimoto T; Motohiro K; Yoshida H; Taniguchi H; Saito Y; Yasuhiro O; Ochiai A; Hiraoka N
Histopathology; 2017 Oct; 71(4):601-609. PubMed ID: 28543708
[TBL] [Abstract][Full Text] [Related]
3. RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.
Hilkens J; Timmer NC; Boer M; Ikink GJ; Schewe M; Sacchetti A; Koppens MAJ; Song JY; Bakker ERM
Gut; 2017 Jun; 66(6):1095-1105. PubMed ID: 27511199
[TBL] [Abstract][Full Text] [Related]
4. Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma.
Sekine S; Yamashita S; Tanabe T; Hashimoto T; Yoshida H; Taniguchi H; Kojima M; Shinmura K; Saito Y; Hiraoka N; Ushijima T; Ochiai A
J Pathol; 2016 Jun; 239(2):133-8. PubMed ID: 26924569
[TBL] [Abstract][Full Text] [Related]
5. R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
Han T; Schatoff EM; Murphy C; Zafra MP; Wilkinson JE; Elemento O; Dow LE
Nat Commun; 2017 Jul; 8():15945. PubMed ID: 28695896
[TBL] [Abstract][Full Text] [Related]
6. RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations.
Fischer MM; Yeung VP; Cattaruzza F; Hussein R; Yen WC; Murriel C; Evans JW; O'Young G; Brunner AL; Wang M; Cain J; Cancilla B; Kapoun A; Hoey T
Sci Rep; 2017 Nov; 7(1):15270. PubMed ID: 29127379
[TBL] [Abstract][Full Text] [Related]
7. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.
Liu J; Pan S; Hsieh MH; Ng N; Sun F; Wang T; Kasibhatla S; Schuller AG; Li AG; Cheng D; Li J; Tompkins C; Pferdekamper A; Steffy A; Cheng J; Kowal C; Phung V; Guo G; Wang Y; Graham MP; Flynn S; Brenner JC; Li C; Villarroel MC; Schultz PG; Wu X; McNamara P; Sellers WR; Petruzzelli L; Boral AL; Seidel HM; McLaughlin ME; Che J; Carey TE; Vanasse G; Harris JL
Proc Natl Acad Sci U S A; 2013 Dec; 110(50):20224-9. PubMed ID: 24277854
[TBL] [Abstract][Full Text] [Related]
8. Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma.
Li J; Wu G; Xu Y; Li J; Ruan N; Chen Y; Zhang Q; Xia Q
Biomed Res Int; 2020; 2020():2527643. PubMed ID: 32104684
[TBL] [Abstract][Full Text] [Related]
9. Evaluation of antitumor effects of aspirin and LGK974 drugs on cellular signaling pathways, cell cycle and apoptosis in colorectal cancer cell lines compared to oxaliplatin drug.
Bagheri M; Tabatabae Far MA; Mirzaei H; Ghasemi F
Fundam Clin Pharmacol; 2020 Feb; 34(1):51-64. PubMed ID: 31233627
[TBL] [Abstract][Full Text] [Related]
10. Porcupine inhibitor LGK‑974 inhibits Wnt/β‑catenin signaling and modifies tumor‑associated macrophages resulting in inhibition of the malignant behaviors of non‑small cell lung cancer cells.
Tang Y; Jiang M; Chen A; Qu W; Han X; Zuo J; Xu G; Song Y; Chen C; Ke X
Mol Med Rep; 2021 Aug; 24(2):. PubMed ID: 34080032
[TBL] [Abstract][Full Text] [Related]
11. Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells.
Kahlert UD; Suwala AK; Koch K; Natsumeda M; Orr BA; Hayashi M; Maciaczyk J; Eberhart CG
J Neuropathol Exp Neurol; 2015 Sep; 74(9):889-900. PubMed ID: 26222502
[TBL] [Abstract][Full Text] [Related]
12. RSPO fusion transcripts in colorectal cancer in Japanese population.
Shinmura K; Kahyo T; Kato H; Igarashi H; Matsuura S; Nakamura S; Kurachi K; Nakamura T; Ogawa H; Funai K; Tanahashi M; Niwa H; Sugimura H
Mol Biol Rep; 2014 Aug; 41(8):5375-84. PubMed ID: 24847761
[TBL] [Abstract][Full Text] [Related]
13. RSPO3 promotes the aggressiveness of bladder cancer via Wnt/β-catenin and Hedgehog signaling pathways.
Chen Z; Zhou L; Chen L; Xiong M; Kazobinka G; Pang Z; Hou T
Carcinogenesis; 2019 Apr; 40(2):360-369. PubMed ID: 30329043
[TBL] [Abstract][Full Text] [Related]
14. Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.
Scholz B; Korn C; Wojtarowicz J; Mogler C; Augustin I; Boutros M; Niehrs C; Augustin HG
Dev Cell; 2016 Jan; 36(1):79-93. PubMed ID: 26766444
[TBL] [Abstract][Full Text] [Related]
15. LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974.
Jang J; Jung Y; Kim Y; Jho EH; Yoon Y
Sci Rep; 2017 Jan; 7():41612. PubMed ID: 28128299
[TBL] [Abstract][Full Text] [Related]
16. Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway.
Shah K; Panchal S; Patel B
Pharmacol Res; 2021 May; 167():105532. PubMed ID: 33677106
[TBL] [Abstract][Full Text] [Related]
17. Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness.
Gong X; Yi J; Carmon KS; Crumbley CA; Xiong W; Thomas A; Fan X; Guo S; An Z; Chang JT; Liu QJ
Oncogene; 2015 Sep; 34(36):4692-701. PubMed ID: 25531322
[TBL] [Abstract][Full Text] [Related]
18. R-spondin-3 promotes proliferation and invasion of breast cancer cells independently of Wnt signaling.
Ter Steege EJ; Doornbos LW; Haughton PD; van Diest PJ; Hilkens J; Derksen PWB; Bakker ERM
Cancer Lett; 2023 Aug; 568():216301. PubMed ID: 37406727
[TBL] [Abstract][Full Text] [Related]
19. R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.
Conboy CB; Vélez-Reyes GL; Rathe SK; Abrahante JE; Temiz NA; Burns MB; Harris RS; Starr TK; Largaespada DA
DNA Cell Biol; 2021 Jan; 40(1):70-79. PubMed ID: 33320737
[TBL] [Abstract][Full Text] [Related]
20. The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor.
Tzeng HE; Yang L; Chen K; Wang Y; Liu YR; Pan SL; Gaur S; Hu S; Yen Y
Oncotarget; 2015 May; 6(13):11061-73. PubMed ID: 25857298
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]