These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

153 related articles for article (PubMed ID: 28105288)

  • 1. Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.
    Petrilli WL; Hoyt SB; London C; McMasters D; Verras A; Struthers M; Cully D; Wisniewski T; Ren N; Bopp C; Sok A; Chen Q; Li Y; Tung E; Tang W; Salituro G; Knemeyer I; Karanam B; Clemas J; Zhou G; Gibson J; Shipley CA; MacNeil DJ; Duffy R; Tata JR; Ujjainwalla F; Ali A; Xiong Y
    ACS Med Chem Lett; 2017 Jan; 8(1):128-132. PubMed ID: 28105288
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.
    Hoyt SB; Taylor J; London C; Ali A; Ujjainwalla F; Tata J; Struthers M; Cully D; Wisniewski T; Ren N; Bopp C; Sok A; Verras A; McMasters D; Chen Q; Tung E; Tang W; Salituro G; Clemas J; Zhou G; MacNeil D; Duffy R; Xiong Y
    Bioorg Med Chem Lett; 2017 Jun; 27(11):2384-2388. PubMed ID: 28416132
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
    Hoyt SB; Park MK; London C; Xiong Y; Tata J; Bennett DJ; Cooke A; Cai J; Carswell E; Robinson J; MacLean J; Brown L; Belshaw S; Clarkson TR; Liu K; Liang GB; Struthers M; Cully D; Wisniewski T; Ren N; Bopp C; Sok A; Cai TQ; Stribling S; Pai LY; Ma X; Metzger J; Verras A; McMasters D; Chen Q; Tung E; Tang W; Salituro G; Buist N; Kuethe J; Rivera N; Clemas J; Zhou G; Gibson J; Maxwell CA; Lassman M; McLaughlin T; Castro-Perez J; Szeto D; Forrest G; Hajdu R; Rosenbach M; Ali A
    ACS Med Chem Lett; 2015 May; 6(5):573-8. PubMed ID: 26005536
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
    Hoyt SB; Petrilli W; London C; Liang GB; Tata J; Hu Q; Yin L; van Koppen CJ; Hartmann RW; Struthers M; Wisniewski T; Ren N; Bopp C; Sok A; Cai TQ; Stribling S; Pai LY; Ma X; Metzger J; Verras A; McMasters D; Chen Q; Tung E; Tang W; Salituro G; Buist N; Clemas J; Zhou G; Gibson J; Maxwell CA; Lassman M; McLaughlin T; Castro-Perez J; Szeto D; Forrest G; Hajdu R; Rosenbach M; Xiong Y
    ACS Med Chem Lett; 2015 Aug; 6(8):861-5. PubMed ID: 26288685
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors.
    Yin L; Hu Q; Emmerich J; Lo MM; Metzger E; Ali A; Hartmann RW
    J Med Chem; 2014 Jun; 57(12):5179-89. PubMed ID: 24899257
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of Potential Inhibitors of Aldosterone Synthase from Chinese Herbs Using Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation Studies.
    Luo G; Lu F; Qiao L; Chen X; Li G; Zhang Y
    Biomed Res Int; 2016; 2016():4182595. PubMed ID: 27781210
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
    Meredith EL; Ksander G; Monovich LG; Papillon JP; Liu Q; Miranda K; Morris P; Rao C; Burgis R; Capparelli M; Hu QY; Singh A; Rigel DF; Jeng AY; Beil M; Fu F; Hu CW; LaSala D
    ACS Med Chem Lett; 2013 Dec; 4(12):1203-7. PubMed ID: 24900631
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
    Hakki T; Hübel K; Waldmann H; Bernhardt R
    J Steroid Biochem Mol Biol; 2011 May; 125(1-2):120-8. PubMed ID: 21193036
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of Highly Selective Pyrimidine-Based Aldosterone Synthase (CYP11B2) Inhibitors.
    Sparks SM; Danger DP; Hoekstra WJ; Leesnitzer T; Schotzinger RJ; Yates CM; Becherer JD
    ACS Med Chem Lett; 2019 Jul; 10(7):1056-1060. PubMed ID: 31312408
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.
    Grombein CM; Hu Q; Rau S; Zimmer C; Hartmann RW
    Eur J Med Chem; 2015 Jan; 90():788-96. PubMed ID: 25528333
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors.
    Müller-Vieira U; Angotti M; Hartmann RW
    J Steroid Biochem Mol Biol; 2005 Aug; 96(3-4):259-70. PubMed ID: 15985365
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Aldosterone synthase inhibition in humans.
    Azizi M; Amar L; Menard J
    Nephrol Dial Transplant; 2013 Jan; 28(1):36-43. PubMed ID: 23045428
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
    LaSala D; Shibanaka Y; Jeng AY
    Anal Biochem; 2009 Nov; 394(1):56-61. PubMed ID: 19622340
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human.
    Cerny MA; Csengery A; Schmenk J; Frederick K
    J Steroid Biochem Mol Biol; 2015 Nov; 154():197-205. PubMed ID: 26303746
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
    Bureik M; Hübel K; Dragan CA; Scher J; Becker H; Lenz N; Bernhardt R
    Mol Cell Endocrinol; 2004 Mar; 217(1-2):249-54. PubMed ID: 15134825
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.
    Adams CM; Hu CW; Jeng AY; Karki R; Ksander G; Lasala D; Leung-Chu J; Liang G; Liu Q; Meredith E; Rao C; Rigel DF; Shi J; Smith S; Springer C; Zhang C
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4324-7. PubMed ID: 20615692
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells.
    Ehmer PB; Bureik M; Bernhardt R; Müller U; Hartmann RW
    J Steroid Biochem Mol Biol; 2002 Jun; 81(2):173-9. PubMed ID: 12137808
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase.
    Ulmschneider S; Müller-Vieira U; Mitrenga M; Hartmann RW; Oberwinkler-Marchais S; Klein CD; Bureik M; Bernhardt R; Antes I; Lengauer T
    J Med Chem; 2005 Mar; 48(6):1796-805. PubMed ID: 15771425
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 3-Pyridyl substituted aliphatic cycles as CYP11B2 inhibitors: aromaticity abolishment of the core significantly increased selectivity over CYP1A2.
    Yin L; Hu Q; Hartmann RW
    PLoS One; 2012; 7(11):e48048. PubMed ID: 23133610
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases.
    Hu Q; Yin L; Hartmann RW
    J Med Chem; 2014 Jun; 57(12):5011-22. PubMed ID: 24422519
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.