BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

239 related articles for article (PubMed ID: 28140559)

  • 1. Quantitative Conjugated Payload Measurement Using Enzymatic Release of Antibody-Drug Conjugate with Cleavable Linker.
    Rago B; Tumey LN; Wei C; Barletta F; Clark T; Hansel S; Han X
    Bioconjug Chem; 2017 Feb; 28(2):620-626. PubMed ID: 28140559
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Where Did the Linker-Payload Go? A Quantitative Investigation on the Destination of the Released Linker-Payload from an Antibody-Drug Conjugate with a Maleimide Linker in Plasma.
    Wei C; Zhang G; Clark T; Barletta F; Tumey LN; Rago B; Hansel S; Han X
    Anal Chem; 2016 May; 88(9):4979-86. PubMed ID: 27075639
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A Two-Step Immunocapture LC/MS/MS Assay for Plasma Stability and Payload Migration Assessment of Cysteine-Maleimide-Based Antibody Drug Conjugates.
    Dong L; Li C; Locuson C; Chen S; Qian MG
    Anal Chem; 2018 May; 90(10):5989-5994. PubMed ID: 29688004
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates.
    Caculitan NG; Dela Cruz Chuh J; Ma Y; Zhang D; Kozak KR; Liu Y; Pillow TH; Sadowsky J; Cheung TK; Phung Q; Haley B; Lee BC; Akita RW; Sliwkowski MX; Polson AG
    Cancer Res; 2017 Dec; 77(24):7027-7037. PubMed ID: 29046337
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Method development of a novel PK assay for antibody-conjugated drug measurement of ADCs using peptide-linker drug analyte.
    Hyung SJ; Li D; Koppada N; Kaur S; Saad OM
    Anal Bioanal Chem; 2019 May; 411(12):2587-2596. PubMed ID: 30828756
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs.
    Kern JC; Dooney D; Zhang R; Liang L; Brandish PE; Cheng M; Feng G; Beck A; Bresson D; Firdos J; Gately D; Knudsen N; Manibusan A; Sun Y; Garbaccio RM
    Bioconjug Chem; 2016 Sep; 27(9):2081-8. PubMed ID: 27469406
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
    Wei B; Gunzner-Toste J; Yao H; Wang T; Wang J; Xu Z; Chen J; Wai J; Nonomiya J; Tsai SP; Chuh J; Kozak KR; Liu Y; Yu SF; Lau J; Li G; Phillips GD; Leipold D; Kamath A; Su D; Xu K; Eigenbrot C; Steinbacher S; Ohri R; Raab H; Staben LR; Zhao G; Flygare JA; Pillow TH; Verma V; Masterson LA; Howard PW; Safina B
    J Med Chem; 2018 Feb; 61(3):989-1000. PubMed ID: 29227683
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cleavable linkers in antibody-drug conjugates.
    Bargh JD; Isidro-Llobet A; Parker JS; Spring DR
    Chem Soc Rev; 2019 Aug; 48(16):4361-4374. PubMed ID: 31294429
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effect of attachment site on stability of cleavable antibody drug conjugates.
    Dorywalska M; Strop P; Melton-Witt JA; Hasa-Moreno A; Farias SE; Galindo Casas M; Delaria K; Lui V; Poulsen K; Loo C; Krimm S; Bolton G; Moine L; Dushin R; Tran TT; Liu SH; Rickert M; Foletti D; Shelton DL; Pons J; Rajpal A
    Bioconjug Chem; 2015 Apr; 26(4):650-9. PubMed ID: 25643134
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Calculated conjugated payload from immunoassay and LC-MS intact protein analysis measurements of antibody-drug conjugate.
    Rago B; Clark T; King L; Zhang J; Tumey LN; Li F; Barletta F; Wei C; Leal M; Hansel S; Han X
    Bioanalysis; 2016 Nov; 8(21):2205-2217. PubMed ID: 27682846
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The Properties of Cysteine-Conjugated Antibody-Drug Conjugates Are Impacted by the IgG Subclass.
    Datta-Mannan A; Choi H; Stokell D; Tang J; Murphy A; Wrobleski A; Feng Y
    AAPS J; 2018 Sep; 20(6):103. PubMed ID: 30255287
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Practical approaches for overcoming challenges in heightened characterization of antibody-drug conjugates with new methodologies and ultrahigh-resolution mass spectrometry.
    Friese OV; Smith JN; Brown PW; Rouse JC
    MAbs; 2018 Apr; 10(3):335-345. PubMed ID: 29393747
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Drug-to-antibody determination for an antibody-drug-conjugate utilizing cathepsin B digestion coupled with reversed-phase high-pressure liquid chromatography analysis.
    Adamo M; Sun G; Qiu D; Valente J; Lan W; Song H; Bolgar M; Katiyar A; Krishnamurthy G
    J Chromatogr A; 2017 Jan; 1481():44-52. PubMed ID: 28017567
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC-MS/MS approach: Assay development, validation, and a case study.
    Liu A; Kozhich A; Passmore D; Gu H; Wong R; Zambito F; Rangan VS; Myler H; Aubry AF; Arnold ME; Wang J
    J Chromatogr B Analyt Technol Biomed Life Sci; 2015 Oct; 1002():54-62. PubMed ID: 26310897
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.
    Ponte JF; Sun X; Yoder NC; Fishkin N; Laleau R; Coccia J; Lanieri L; Bogalhas M; Wang L; Wilhelm S; Widdison W; Pinkas J; Keating TA; Chari R; Erickson HK; Lambert JM
    Bioconjug Chem; 2016 Jul; 27(7):1588-98. PubMed ID: 27174129
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The Chemical Design and Synthesis of Linkers Used in Antibody Drug Conjugates.
    Frigerio M; Kyle AF
    Curr Top Med Chem; 2017; 17(32):3393-3424. PubMed ID: 29357801
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Determination of drug-to-antibody ratio of antibody-drug conjugate in biological samples using microflow-liquid chromatography/high-resolution mass spectrometry.
    Inoue K; Mochizuki T; Kasamori N; Komori T
    Bioanalysis; 2022 Dec; 14(24):1533-1545. PubMed ID: 36825963
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates.
    Lee MV; Kaur S; Saad OM
    Anal Chem; 2020 Sep; 92(18):12168-12175. PubMed ID: 32786429
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes.
    Drake PM; Albers AE; Baker J; Banas S; Barfield RM; Bhat AS; de Hart GW; Garofalo AW; Holder P; Jones LC; Kudirka R; McFarland J; Zmolek W; Rabuka D
    Bioconjug Chem; 2014 Jul; 25(7):1331-41. PubMed ID: 24924618
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Antibody-drug conjugates: recent advances in conjugation and linker chemistries.
    Tsuchikama K; An Z
    Protein Cell; 2018 Jan; 9(1):33-46. PubMed ID: 27743348
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.