631 related articles for article (PubMed ID: 28140580)
1. Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry.
Fronik P; Gaiser BI; Sejer Pedersen D
J Med Chem; 2017 May; 60(10):4126-4134. PubMed ID: 28140580
[TBL] [Abstract][Full Text] [Related]
2. Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors.
Feng Z; Hu G; Ma S; Xie XQ
AAPS J; 2015 Sep; 17(5):1080-95. PubMed ID: 25940084
[TBL] [Abstract][Full Text] [Related]
3. Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.
Valant C; Sexton PM; Christopoulos A
Mol Interv; 2009 Jun; 9(3):125-35. PubMed ID: 19592673
[TBL] [Abstract][Full Text] [Related]
4. Bridging the gap: bitopic ligands of G-protein-coupled receptors.
Lane JR; Sexton PM; Christopoulos A
Trends Pharmacol Sci; 2013 Jan; 34(1):59-66. PubMed ID: 23177916
[TBL] [Abstract][Full Text] [Related]
5. Recent Advances in the Drug Discovery and Development of Dualsteric/ Bitopic Activators of G Protein-Coupled Receptors.
Reinecke BA; Wang H; Zhang Y
Curr Top Med Chem; 2019; 19(26):2378-2392. PubMed ID: 31833462
[TBL] [Abstract][Full Text] [Related]
6. Strategies for the identification of allosteric modulators of G-protein-coupled receptors.
Burford NT; Watson J; Bertekap R; Alt A
Biochem Pharmacol; 2011 Mar; 81(6):691-702. PubMed ID: 21184747
[TBL] [Abstract][Full Text] [Related]
7. Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.
Mohr K; Schmitz J; Schrage R; Tränkle C; Holzgrabe U
Angew Chem Int Ed Engl; 2013 Jan; 52(2):508-16. PubMed ID: 23225228
[TBL] [Abstract][Full Text] [Related]
8. Current and Future Challenges in GPCR Drug Discovery.
Topiol S
Methods Mol Biol; 2018; 1705():1-21. PubMed ID: 29188556
[TBL] [Abstract][Full Text] [Related]
9. The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors.
Valant C; Robert Lane J; Sexton PM; Christopoulos A
Annu Rev Pharmacol Toxicol; 2012; 52():153-78. PubMed ID: 21910627
[TBL] [Abstract][Full Text] [Related]
10. Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands.
Gado F; Ferrisi R; Polini B; Mohamed KA; Ricardi C; Lucarini E; Carpi S; Domenichini F; Stevenson LA; Rapposelli S; Saccomanni G; Nieri P; Ortore G; Pertwee RG; Ghelardini C; Di Cesare Mannelli L; Chiellini G; Laprairie RB; Manera C
J Med Chem; 2022 Jul; 65(14):9918-9938. PubMed ID: 35849804
[TBL] [Abstract][Full Text] [Related]
11. Probing the Existence of a Metastable Binding Site at the β
Gaiser BI; Danielsen M; Marcher-Rørsted E; Røpke Jørgensen K; Wróbel TM; Frykman M; Johansson H; Bräuner-Osborne H; Gloriam DE; Mathiesen JM; Sejer Pedersen D
J Med Chem; 2019 Sep; 62(17):7806-7839. PubMed ID: 31298548
[TBL] [Abstract][Full Text] [Related]
12. Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
Keov P; Sexton PM; Christopoulos A
Neuropharmacology; 2011 Jan; 60(1):24-35. PubMed ID: 20637785
[TBL] [Abstract][Full Text] [Related]
13. Advances in G protein-coupled receptor allostery: from function to structure.
Christopoulos A
Mol Pharmacol; 2014 Nov; 86(5):463-78. PubMed ID: 25061106
[TBL] [Abstract][Full Text] [Related]
14. Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule.
Egyed A; Kelemen ÁA; Vass M; Visegrády A; Thee SA; Wang Z; de Graaf C; Brea J; Loza MI; Leurs R; Keserű GM
Bioorg Chem; 2021 Jun; 111():104832. PubMed ID: 33826962
[TBL] [Abstract][Full Text] [Related]
15. Allosteric ligands for G protein-coupled receptors: a novel strategy with attractive therapeutic opportunities.
De Amici M; Dallanoce C; Holzgrabe U; Tränkle C; Mohr K
Med Res Rev; 2010 May; 30(3):463-549. PubMed ID: 19557759
[TBL] [Abstract][Full Text] [Related]
16. Overview of receptor allosterism.
Gregory KJ; Sexton PM; Christopoulos A
Curr Protoc Pharmacol; 2010 Dec; Chapter 1():Unit 1.21. PubMed ID: 21935895
[TBL] [Abstract][Full Text] [Related]
17. 2016 Philip S. Portoghese Medicinal Chemistry Lectureship: Designing Bivalent or Bitopic Molecules for G-Protein Coupled Receptors. The Whole Is Greater Than the Sum of Its Parts.
Newman AH; Battiti FO; Bonifazi A
J Med Chem; 2020 Mar; 63(5):1779-1797. PubMed ID: 31499001
[TBL] [Abstract][Full Text] [Related]
18. Allosteric binding sites at the receptor-lipid bilayer interface: novel targets for GPCR drug discovery.
Wang Y; Yu Z; Xiao W; Lu S; Zhang J
Drug Discov Today; 2021 Mar; 26(3):690-703. PubMed ID: 33301977
[TBL] [Abstract][Full Text] [Related]
19. Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators.
Grundmann M; Bender E; Schamberger J; Eitner F
Int J Mol Sci; 2021 Feb; 22(4):. PubMed ID: 33578942
[TBL] [Abstract][Full Text] [Related]
20. Allosteric modulators of G-protein-coupled receptors.
May LT; Christopoulos A
Curr Opin Pharmacol; 2003 Oct; 3(5):551-6. PubMed ID: 14559102
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]