234 related articles for article (PubMed ID: 28143939)
1. Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.
Moon J; Zhou H; Zhang LS; Tan W; Liu Y; Zhang S; Morlock LK; Bao X; Palecek SP; Feng JQ; Williams NS; Amatruda JF; Olson EN; Bassel-Duby R; Lum L
Proc Natl Acad Sci U S A; 2017 Feb; 114(7):1649-1654. PubMed ID: 28143939
[TBL] [Abstract][Full Text] [Related]
2. Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction.
Yang D; Fu W; Li L; Xia X; Liao Q; Yue R; Chen H; Chen X; An S; Zeng C; Wang WE
Clin Sci (Lond); 2017 Dec; 131(24):2919-2932. PubMed ID: 29162747
[TBL] [Abstract][Full Text] [Related]
3. Chemical Modulation of WNT Signaling in Cancer.
Zhang LS; Lum L
Prog Mol Biol Transl Sci; 2018 Jan; 153():245-269. PubMed ID: 29389519
[TBL] [Abstract][Full Text] [Related]
4. Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway.
Shah K; Panchal S; Patel B
Pharmacol Res; 2021 May; 167():105532. PubMed ID: 33677106
[TBL] [Abstract][Full Text] [Related]
5. An
Asciolla JJ; Miele MM; Hendrickson RC; Resh MD
J Biol Chem; 2017 Aug; 292(33):13507-13513. PubMed ID: 28655768
[TBL] [Abstract][Full Text] [Related]
6. Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma.
Li J; Wu G; Xu Y; Li J; Ruan N; Chen Y; Zhang Q; Xia Q
Biomed Res Int; 2020; 2020():2527643. PubMed ID: 32104684
[TBL] [Abstract][Full Text] [Related]
7. Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors.
Dong Y; Li K; Xu Z; Ma H; Zheng J; Hu Z; He S; Wu Y; Sun Z; Luo L; Li J; Zhang H; Zhang X
Bioorg Med Chem; 2015 Nov; 23(21):6855-68. PubMed ID: 26455655
[TBL] [Abstract][Full Text] [Related]
8. Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.
Dodge ME; Moon J; Tuladhar R; Lu J; Jacob LS; Zhang LS; Shi H; Wang X; Moro E; Mongera A; Argenton F; Karner CM; Carroll TJ; Chen C; Amatruda JF; Lum L
J Biol Chem; 2012 Jun; 287(27):23246-54. PubMed ID: 22593577
[TBL] [Abstract][Full Text] [Related]
9. Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN).
Tuladhar R; Yarravarapu N; Ma Y; Zhang C; Herbert J; Kim J; Chen C; Lum L
J Biol Chem; 2019 Apr; 294(16):6273-6282. PubMed ID: 30737280
[TBL] [Abstract][Full Text] [Related]
10. Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Liu Y; Qi X; Donnelly L; Elghobashi-Meinhardt N; Long T; Zhou RW; Sun Y; Wang B; Li X
Nature; 2022 Jul; 607(7920):816-822. PubMed ID: 35831507
[TBL] [Abstract][Full Text] [Related]
11. Wnt family member 4 (WNT4) and WNT3A activate cell-autonomous Wnt signaling independent of porcupine
Rao DM; Shackleford MT; Bordeaux EK; Sottnik JL; Ferguson RL; Yamamoto TM; Wellberg EA; Bitler BG; Sikora MJ
J Biol Chem; 2019 Dec; 294(52):19950-19966. PubMed ID: 31740580
[TBL] [Abstract][Full Text] [Related]
12. The porcupine inhibitor WNT974 provokes ectodermal lineage differentiation of human embryonic stem cells.
Kalantary-Charvadeh A; Hosseini V; Mehdizadeh A; Nazari Soltan Ahmad S; Rahbarghazi R; Nozad Charoudeh H; Nouri M; Darabi M
Cell Biochem Funct; 2022 Jun; 40(4):359-368. PubMed ID: 35445405
[TBL] [Abstract][Full Text] [Related]
13. Loss of Porcupine impairs convergent extension during gastrulation in zebrafish.
Chen Q; Takada R; Takada S
J Cell Sci; 2012 May; 125(Pt 9):2224-34. PubMed ID: 22357957
[TBL] [Abstract][Full Text] [Related]
14. Porcupine inhibitor LGK‑974 inhibits Wnt/β‑catenin signaling and modifies tumor‑associated macrophages resulting in inhibition of the malignant behaviors of non‑small cell lung cancer cells.
Tang Y; Jiang M; Chen A; Qu W; Han X; Zuo J; Xu G; Song Y; Chen C; Ke X
Mol Med Rep; 2021 Aug; 24(2):. PubMed ID: 34080032
[TBL] [Abstract][Full Text] [Related]
15. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.
Liu J; Pan S; Hsieh MH; Ng N; Sun F; Wang T; Kasibhatla S; Schuller AG; Li AG; Cheng D; Li J; Tompkins C; Pferdekamper A; Steffy A; Cheng J; Kowal C; Phung V; Guo G; Wang Y; Graham MP; Flynn S; Brenner JC; Li C; Villarroel MC; Schultz PG; Wu X; McNamara P; Sellers WR; Petruzzelli L; Boral AL; Seidel HM; McLaughlin ME; Che J; Carey TE; Vanasse G; Harris JL
Proc Natl Acad Sci U S A; 2013 Dec; 110(50):20224-9. PubMed ID: 24277854
[TBL] [Abstract][Full Text] [Related]
16. Delivery of the Porcupine Inhibitor WNT974 in Mice.
Zhang LS; Lum L
Methods Mol Biol; 2016; 1481():111-7. PubMed ID: 27590157
[TBL] [Abstract][Full Text] [Related]
17. Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.
Madan B; Patel MB; Zhang J; Bunte RM; Rudemiller NP; Griffiths R; Virshup DM; Crowley SD
Kidney Int; 2016 May; 89(5):1062-1074. PubMed ID: 27083283
[TBL] [Abstract][Full Text] [Related]
18. Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction.
Luther DJ; Thodeti CK; Shamhart PE; Adapala RK; Hodnichak C; Weihrauch D; Bonaldo P; Chilian WM; Meszaros JG
Circ Res; 2012 Mar; 110(6):851-6. PubMed ID: 22343710
[TBL] [Abstract][Full Text] [Related]
19. WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma.
Zimmerli D; Cecconi V; Valenta T; Hausmann G; Cantù C; Restivo G; Hafner J; Basler K; van den Broek M
Oncogene; 2018 Jul; 37(27):3753-3762. PubMed ID: 29662191
[TBL] [Abstract][Full Text] [Related]
20.
Lee CJ; Rana MS; Bae C; Li Y; Banerjee A
J Biol Chem; 2019 Jan; 294(1):231-245. PubMed ID: 30420431
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
