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2. A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation. Ruff EF; Muretta JM; Thompson AR; Lake EW; Cyphers S; Albanese SK; Hanson SM; Behr JM; Thomas DD; Chodera JD; Levinson NM Elife; 2018 Feb; 7():. PubMed ID: 29465396 [TBL] [Abstract][Full Text] [Related]
3. Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states. Lake EW; Muretta JM; Thompson AR; Rasmussen DM; Majumdar A; Faber EB; Ruff EF; Thomas DD; Levinson NM Proc Natl Acad Sci U S A; 2018 Dec; 115(51):E11894-E11903. PubMed ID: 30518564 [TBL] [Abstract][Full Text] [Related]
4. Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2. Zorba A; Buosi V; Kutter S; Kern N; Pontiggia F; Cho YJ; Kern D Elife; 2014 May; 3():e02667. PubMed ID: 24867643 [TBL] [Abstract][Full Text] [Related]
5. Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions. James KA; Verkhivker GM PLoS One; 2014; 9(11):e113488. PubMed ID: 25427151 [TBL] [Abstract][Full Text] [Related]
6. The multifaceted allosteric regulation of Aurora kinase A. Levinson NM Biochem J; 2018 Jun; 475(12):2025-2042. PubMed ID: 29946042 [TBL] [Abstract][Full Text] [Related]
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8. A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix. Rennie YK; McIntyre PJ; Akindele T; Bayliss R; Jamieson AG ACS Chem Biol; 2016 Dec; 11(12):3383-3390. PubMed ID: 27775325 [TBL] [Abstract][Full Text] [Related]
9. Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy. Gilburt JAH; Sarkar H; Sheldrake P; Blagg J; Ying L; Dodson CA Angew Chem Int Ed Engl; 2017 Sep; 56(38):11409-11414. PubMed ID: 28700101 [TBL] [Abstract][Full Text] [Related]
10. Issues in interpreting the in vivo activity of Aurora-A. Shagisultanova E; Dunbrack RL; Golemis EA Expert Opin Ther Targets; 2015 Feb; 19(2):187-200. PubMed ID: 25384454 [TBL] [Abstract][Full Text] [Related]
11. Ancient origins of allosteric activation in a Ser-Thr kinase. Hadzipasic A; Wilson C; Nguyen V; Kern N; Kim C; Pitsawong W; Villali J; Zheng Y; Kern D Science; 2020 Feb; 367(6480):912-917. PubMed ID: 32079772 [TBL] [Abstract][Full Text] [Related]
12. Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain. Burgess SG; Oleksy A; Cavazza T; Richards MW; Vernos I; Matthews D; Bayliss R Open Biol; 2016 Jul; 6(7):. PubMed ID: 27411893 [TBL] [Abstract][Full Text] [Related]
13. Allosteric inhibition of c-Met kinase in sub-microsecond molecular dynamics simulations induced by its inhibitor, tivantinib. Yan M; Wang H; Wang Q; Zhang Z; Zhang C Phys Chem Chem Phys; 2016 Apr; 18(15):10367-74. PubMed ID: 27029952 [TBL] [Abstract][Full Text] [Related]
14. A non-mitotic role for Aurora kinase A as a direct activator of cell migration upon interaction with PLD, FAK and Src. Mahankali M; Henkels KM; Speranza F; Gomez-Cambronero J J Cell Sci; 2015 Feb; 128(3):516-26. PubMed ID: 25501815 [TBL] [Abstract][Full Text] [Related]
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17. HRD Motif as the Central Hub of the Signaling Network for Activation Loop Autophosphorylation in Abl Kinase. La Sala G; Riccardi L; Gaspari R; Cavalli A; Hantschel O; De Vivo M J Chem Theory Comput; 2016 Nov; 12(11):5563-5574. PubMed ID: 27682200 [TBL] [Abstract][Full Text] [Related]
18. Conformational analysis of the DFG-out kinase motif and biochemical profiling of structurally validated type II inhibitors. Vijayan RS; He P; Modi V; Duong-Ly KC; Ma H; Peterson JR; Dunbrack RL; Levy RM J Med Chem; 2015 Jan; 58(1):466-79. PubMed ID: 25478866 [TBL] [Abstract][Full Text] [Related]
19. Computational study of the "DFG-flip" conformational transition in c-Abl and c-Src tyrosine kinases. Meng Y; Lin YL; Roux B J Phys Chem B; 2015 Jan; 119(4):1443-56. PubMed ID: 25548962 [TBL] [Abstract][Full Text] [Related]
20. A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A. Martin MP; Zhu JY; Lawrence HR; Pireddu R; Luo Y; Alam R; Ozcan S; Sebti SM; Lawrence NJ; Schönbrunn E ACS Chem Biol; 2012 Apr; 7(4):698-706. PubMed ID: 22248356 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]