184 related articles for article (PubMed ID: 28186757)
1. Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
Vianello P; Sartori L; Amigoni F; Cappa A; Fagá G; Fattori R; Legnaghi E; Ciossani G; Mattevi A; Meroni G; Moretti L; Cecatiello V; Pasqualato S; Romussi A; Thaler F; Trifiró P; Villa M; Botrugno OA; Dessanti P; Minucci S; Vultaggio S; Zagarrí E; Varasi M; Mercurio C
J Med Chem; 2017 Mar; 60(5):1693-1715. PubMed ID: 28186757
[TBL] [Abstract][Full Text] [Related]
2. Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.
Sartori L; Mercurio C; Amigoni F; Cappa A; Fagá G; Fattori R; Legnaghi E; Ciossani G; Mattevi A; Meroni G; Moretti L; Cecatiello V; Pasqualato S; Romussi A; Thaler F; Trifiró P; Villa M; Vultaggio S; Botrugno OA; Dessanti P; Minucci S; Zagarrí E; Carettoni D; Iuzzolino L; Varasi M; Vianello P
J Med Chem; 2017 Mar; 60(5):1673-1692. PubMed ID: 28186755
[TBL] [Abstract][Full Text] [Related]
3. Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.
Vianello P; Botrugno OA; Cappa A; Ciossani G; Dessanti P; Mai A; Mattevi A; Meroni G; Minucci S; Thaler F; Tortorici M; Trifiró P; Valente S; Villa M; Varasi M; Mercurio C
Eur J Med Chem; 2014 Oct; 86():352-63. PubMed ID: 25173853
[TBL] [Abstract][Full Text] [Related]
4. 4-Hydroxy-3-methylbenzofuran-2-carbohydrazones as novel LSD1 inhibitors.
He X; Gao Y; Hui Z; Shen G; Wang S; Xie T; Ye XY
Bioorg Med Chem Lett; 2020 May; 30(10):127109. PubMed ID: 32201021
[TBL] [Abstract][Full Text] [Related]
5. Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1.
Dai XJ; Liu Y; Xue LP; Xiong XP; Zhou Y; Zheng YC; Liu HM
J Med Chem; 2021 Mar; 64(5):2466-2488. PubMed ID: 33619958
[TBL] [Abstract][Full Text] [Related]
6. Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.
Amano Y; Kikuchi M; Sato S; Yokoyama S; Umehara T; Umezawa N; Higuchi T
Bioorg Med Chem; 2017 May; 25(9):2617-2624. PubMed ID: 28336409
[TBL] [Abstract][Full Text] [Related]
7. Synthesis, structure-activity relationship studies and biological characterization of new [1,2,4]triazolo[1,5-a]pyrimidine-based LSD1/KDM1A inhibitors.
Wang S; Li ZR; Suo FZ; Yuan XH; Yu B; Liu HM
Eur J Med Chem; 2019 Apr; 167():388-401. PubMed ID: 30780087
[TBL] [Abstract][Full Text] [Related]
8. Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.
Vianello P; Botrugno OA; Cappa A; Dal Zuffo R; Dessanti P; Mai A; Marrocco B; Mattevi A; Meroni G; Minucci S; Stazi G; Thaler F; Trifiró P; Valente S; Villa M; Varasi M; Mercurio C
J Med Chem; 2016 Feb; 59(4):1501-17. PubMed ID: 26702542
[TBL] [Abstract][Full Text] [Related]
9. Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.
Zhou C; Kang D; Xu Y; Zhang L; Zha X
Chem Biol Drug Des; 2015 Jun; 85(6):659-71. PubMed ID: 25346381
[TBL] [Abstract][Full Text] [Related]
10. Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1.
Mould DP; Bremberg U; Jordan AM; Geitmann M; McGonagle AE; Somervaille TCP; Spencer GJ; Ogilvie DJ
Bioorg Med Chem Lett; 2017 Oct; 27(20):4755-4759. PubMed ID: 28927796
[TBL] [Abstract][Full Text] [Related]
11. Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A).
Borrello MT; Schinor B; Bartels K; Benelkebir H; Pereira S; Al-Jamal WT; Douglas L; Duriez PJ; Packham G; Haufe G; Ganesan A
Bioorg Med Chem Lett; 2017 May; 27(10):2099-2101. PubMed ID: 28390942
[TBL] [Abstract][Full Text] [Related]
12. Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.
Trifirò P; Cappa A; Brambillasca S; Botrugno OA; Cera MR; Zuffo RD; Dessanti P; Meroni G; Thaler F; Villa M; Minucci S; Mercurio C; Varasi M; Vianello P
Future Med Chem; 2017 Jul; 9(11):1161-1174. PubMed ID: 28722470
[TBL] [Abstract][Full Text] [Related]
13. High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases.
Yu V; Fisch T; Long AM; Tang J; Lee JH; Hierl M; Chen H; Yakowec P; Schwandner R; Emkey R
J Biomol Screen; 2012 Jan; 17(1):27-38. PubMed ID: 21859682
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis and in vitro evaluation of stilbene derivatives as novel LSD1 inhibitors for AML therapy.
Duan Y; Qin W; Suo F; Zhai X; Guan Y; Wang X; Zheng Y; Liu H
Bioorg Med Chem; 2018 Dec; 26(23-24):6000-6014. PubMed ID: 30448189
[TBL] [Abstract][Full Text] [Related]
15. Synthesis of Carboxamide-Containing Tranylcypromine Analogues as LSD1 (KDM1A) Inhibitors Targeting Acute Myeloid Leukemia.
Teresa Borrello M; Benelkebir H; Lee A; Hin Tam C; Shafat M; Rushworth SA; Bowles KM; Douglas L; Duriez PJ; Bailey S; Crabb SJ; Packham G; Ganesan A
ChemMedChem; 2021 Apr; 16(8):1316-1324. PubMed ID: 33533576
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors.
Wang S; Zhao LJ; Zheng YC; Shen DD; Miao EF; Qiao XP; Zhao LJ; Liu Y; Huang R; Yu B; Liu HM
Eur J Med Chem; 2017 Jan; 125():940-951. PubMed ID: 27769034
[TBL] [Abstract][Full Text] [Related]
17. Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A.
Pieroni M; Annunziato G; Azzali E; Dessanti P; Mercurio C; Meroni G; Trifiró P; Vianello P; Villa M; Beato C; Varasi M; Costantino G
Eur J Med Chem; 2015 Mar; 92():377-86. PubMed ID: 25585008
[TBL] [Abstract][Full Text] [Related]
18. 3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.
Wu F; Zhou C; Yao Y; Wei L; Feng Z; Deng L; Song Y
J Med Chem; 2016 Jan; 59(1):253-263. PubMed ID: 26652247
[TBL] [Abstract][Full Text] [Related]
19. Experience-based discovery (EBD) of aryl hydrazines as new scaffolds for the development of LSD1/KDM1A inhibitors.
Li ZR; Wang S; Yang L; Yuan XH; Suo FZ; Yu B; Liu HM
Eur J Med Chem; 2019 Mar; 166():432-444. PubMed ID: 30739825
[TBL] [Abstract][Full Text] [Related]
20. Chemoprobe-based assays of histone lysine demethylase 1A target occupation enable
Mascaró C; Ortega A; Carceller E; Ruiz Rodriguez R; Ciceri F; Lunardi S; Yu L; Hilbert M; Maes T
J Biol Chem; 2019 May; 294(20):8311-8322. PubMed ID: 30804215
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]