256 related articles for article (PubMed ID: 28202494)
1. Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.
Guitart AV; Panagopoulou TI; Villacreces A; Vukovic M; Sepulveda C; Allen L; Carter RN; van de Lagemaat LN; Morgan M; Giles P; Sas Z; Gonzalez MV; Lawson H; Paris J; Edwards-Hicks J; Schaak K; Subramani C; Gezer D; Armesilla-Diaz A; Wills J; Easterbrook A; Coman D; So CW; O'Carroll D; Vernimmen D; Rodrigues NP; Pollard PJ; Morton NM; Finch A; Kranc KR
J Exp Med; 2017 Mar; 214(3):719-735. PubMed ID: 28202494
[TBL] [Abstract][Full Text] [Related]
2. Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Frezza C; Zheng L; Folger O; Rajagopalan KN; MacKenzie ED; Jerby L; Micaroni M; Chaneton B; Adam J; Hedley A; Kalna G; Tomlinson IP; Pollard PJ; Watson DG; Deberardinis RJ; Shlomi T; Ruppin E; Gottlieb E
Nature; 2011 Aug; 477(7363):225-8. PubMed ID: 21849978
[TBL] [Abstract][Full Text] [Related]
3. A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.
Adam J; Yang M; Bauerschmidt C; Kitagawa M; O'Flaherty L; Maheswaran P; Özkan G; Sahgal N; Baban D; Kato K; Saito K; Iino K; Igarashi K; Stratford M; Pugh C; Tennant DA; Ludwig C; Davies B; Ratcliffe PJ; El-Bahrawy M; Ashrafian H; Soga T; Pollard PJ
Cell Rep; 2013 May; 3(5):1440-8. PubMed ID: 23643539
[TBL] [Abstract][Full Text] [Related]
4. Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.
O'Flaherty L; Adam J; Heather LC; Zhdanov AV; Chung YL; Miranda MX; Croft J; Olpin S; Clarke K; Pugh CW; Griffiths J; Papkovsky D; Ashrafian H; Ratcliffe PJ; Pollard PJ
Hum Mol Genet; 2010 Oct; 19(19):3844-51. PubMed ID: 20660115
[TBL] [Abstract][Full Text] [Related]
5. Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.
Tyrakis PA; Yurkovich ME; Sciacovelli M; Papachristou EK; Bridges HR; Gaude E; Schreiner A; D'Santos C; Hirst J; Hernandez-Fernaud J; Springett R; Griffiths JR; Frezza C
Cell Rep; 2017 Oct; 21(4):1036-1047. PubMed ID: 29069586
[TBL] [Abstract][Full Text] [Related]
6. Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
Adam J; Hatipoglu E; O'Flaherty L; Ternette N; Sahgal N; Lockstone H; Baban D; Nye E; Stamp GW; Wolhuter K; Stevens M; Fischer R; Carmeliet P; Maxwell PH; Pugh CW; Frizzell N; Soga T; Kessler BM; El-Bahrawy M; Ratcliffe PJ; Pollard PJ
Cancer Cell; 2011 Oct; 20(4):524-37. PubMed ID: 22014577
[TBL] [Abstract][Full Text] [Related]
7. Leukemia cells impair normal hematopoiesis and induce functionally loss of hematopoietic stem cells through immune cells and inflammation.
Cui P; Zhang Y; Cui M; Li Z; Ma G; Wang R; Wang N; Huang S; Gao J
Leuk Res; 2018 Feb; 65():49-54. PubMed ID: 29306107
[TBL] [Abstract][Full Text] [Related]
8. Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity.
Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Miller A; Ellis E; Rydén M; Näslund E; Thorell A; Lauschke VM; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
Gastroenterology; 2021 Dec; 161(6):1982-1997.e11. PubMed ID: 34425095
[TBL] [Abstract][Full Text] [Related]
9. The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation.
Saha N; Ropa J; Chen L; Hu H; Mysliwski M; Friedman A; Maillard I; Muntean AG
Stem Cell Reports; 2019 May; 12(5):1069-1083. PubMed ID: 31031188
[TBL] [Abstract][Full Text] [Related]
10. The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function.
Gu Y; Jones AE; Yang W; Liu S; Dai Q; Liu Y; Swindle CS; Zhou D; Zhang Z; Ryan TM; Townes TM; Klug CA; Chen D; Wang H
Proc Natl Acad Sci U S A; 2016 Jan; 113(1):E51-60. PubMed ID: 26699484
[TBL] [Abstract][Full Text] [Related]
11. Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Ashrafian H; Czibik G; Bellahcene M; Aksentijević D; Smith AC; Mitchell SJ; Dodd MS; Kirwan J; Byrne JJ; Ludwig C; Isackson H; Yavari A; Støttrup NB; Contractor H; Cahill TJ; Sahgal N; Ball DR; Birkler RI; Hargreaves I; Tennant DA; Land J; Lygate CA; Johannsen M; Kharbanda RK; Neubauer S; Redwood C; de Cabo R; Ahmet I; Talan M; Günther UL; Robinson AJ; Viant MR; Pollard PJ; Tyler DJ; Watkins H
Cell Metab; 2012 Mar; 15(3):361-71. PubMed ID: 22405071
[TBL] [Abstract][Full Text] [Related]
12. TWIST1 preserves hematopoietic stem cell function via the CACNA1B/Ca2+/mitochondria axis.
Wang N; Yin J; You N; Yang S; Guo D; Zhao Y; Ru Y; Liu X; Cheng H; Ren Q; Cheng T; Ma X
Blood; 2021 May; 137(21):2907-2919. PubMed ID: 33619534
[TBL] [Abstract][Full Text] [Related]
13. Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues.
Kamp M; Surmacki J; Segarra Mondejar M; Young T; Chrabaszcz K; Joud F; Zecchini V; Speed A; Frezza C; Bohndiek SE
Nat Commun; 2024 Jun; 15(1):5386. PubMed ID: 38918386
[TBL] [Abstract][Full Text] [Related]
14. Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
Hooftman A; Peace CG; Ryan DG; Day EA; Yang M; McGettrick AF; Yin M; Montano EN; Huo L; Toller-Kawahisa JE; Zecchini V; Ryan TAJ; Bolado-Carrancio A; Casey AM; Prag HA; Costa ASH; De Los Santos G; Ishimori M; Wallace DJ; Venuturupalli S; Nikitopoulou E; Frizzell N; Johansson C; Von Kriegsheim A; Murphy MP; Jefferies C; Frezza C; O'Neill LAJ
Nature; 2023 Mar; 615(7952):490-498. PubMed ID: 36890227
[TBL] [Abstract][Full Text] [Related]
15. Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis.
Ariki R; Morikawa S; Mabuchi Y; Suzuki S; Nakatake M; Yoshioka K; Hidano S; Nakauchi H; Matsuzaki Y; Nakamura T; Goitsuka R
PLoS One; 2014; 9(2):e87646. PubMed ID: 24498346
[TBL] [Abstract][Full Text] [Related]
16. Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.
Adam J; Ramracheya R; Chibalina MV; Ternette N; Hamilton A; Tarasov AI; Zhang Q; Rebelato E; Rorsman NJG; Martín-Del-Río R; Lewis A; Özkan G; Do HW; Spégel P; Saitoh K; Kato K; Igarashi K; Kessler BM; Pugh CW; Tamarit-Rodriguez J; Mulder H; Clark A; Frizzell N; Soga T; Ashcroft FM; Silver A; Pollard PJ; Rorsman P
Cell Rep; 2017 Sep; 20(13):3135-3148. PubMed ID: 28954230
[TBL] [Abstract][Full Text] [Related]
17. Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia.
Almotiri A; Alzahrani H; Menendez-Gonzalez JB; Abdelfattah A; Alotaibi B; Saleh L; Greene A; Georgiou M; Gibbs A; Alsayari A; Taha S; Thomas LA; Shah D; Edkins S; Giles P; Stemmler MP; Brabletz S; Brabletz T; Boyd AS; Siebzehnrubl FA; Rodrigues NP
J Clin Invest; 2021 Jan; 131(1):. PubMed ID: 33108352
[TBL] [Abstract][Full Text] [Related]
18. The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.
Sullivan LB; Martinez-Garcia E; Nguyen H; Mullen AR; Dufour E; Sudarshan S; Licht JD; Deberardinis RJ; Chandel NS
Mol Cell; 2013 Jul; 51(2):236-48. PubMed ID: 23747014
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
Ternette N; Yang M; Laroyia M; Kitagawa M; O'Flaherty L; Wolhulter K; Igarashi K; Saito K; Kato K; Fischer R; Berquand A; Kessler BM; Lappin T; Frizzell N; Soga T; Adam J; Pollard PJ
Cell Rep; 2013 Mar; 3(3):689-700. PubMed ID: 23499446
[TBL] [Abstract][Full Text] [Related]
20. Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration.
Komorowska K; Doyle A; Wahlestedt M; Subramaniam A; Debnath S; Chen J; Soneji S; Van Handel B; Mikkola HKA; Miharada K; Bryder D; Larsson J; Magnusson M
Cell Rep; 2017 Dec; 21(12):3514-3523. PubMed ID: 29262330
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
