BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

186 related articles for article (PubMed ID: 28209465)

  • 1. Identification of highly potent and selective PI3Kδ inhibitors.
    Marcoux D; Qin LY; Ruan Z; Shi Q; Ruan Q; Weigelt C; Qiu H; Schieven G; Hynes J; Bhide R; Poss M; Tino J
    Bioorg Med Chem Lett; 2017 Jul; 27(13):2849-2853. PubMed ID: 28209465
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors.
    Bhide RS; Neels J; Qin LY; Ruan Z; Stachura S; Weigelt C; Sack JS; Stefanski K; Gu X; Xie JH; Goldstine CB; Skala S; Pedicord DL; Ruepp S; Dhar TG; Carter PH; Salter-Cid LM; Poss MA; Davies P
    Bioorg Med Chem Lett; 2016 Sep; 26(17):4256-60. PubMed ID: 27476421
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.
    Qin LY; Ruan Z; Cherney RJ; Dhar TGM; Neels J; Weigelt CA; Sack JS; Srivastava AS; Cornelius LAM; Tino JA; Stefanski K; Gu X; Xie J; Susulic V; Yang X; Yarde-Chinn M; Skala S; Bosnius R; Goldstein C; Davies P; Ruepp S; Salter-Cid L; Bhide RS; Poss MA
    Bioorg Med Chem Lett; 2017 Feb; 27(4):855-861. PubMed ID: 28108251
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Optimization and in vivo evaluation of pyrazolopyridines as a potent and selective PI3Kδ inhibitor.
    Hamajima T; Takahashi F; Kato K; Sugano Y; Yamaki S; Moritomo A; Kubo S; Nakamura K; Yamagami K; Hamakawa N; Yokoo K; Fukahori H
    Bioorg Med Chem; 2018 Aug; 26(14):3917-3924. PubMed ID: 29907471
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Potent and highly selective benzimidazole inhibitors of PI3-kinase delta.
    Murray JM; Sweeney ZK; Chan BK; Balazs M; Bradley E; Castanedo G; Chabot C; Chantry D; Flagella M; Goldstein DM; Kondru R; Lesnick J; Li J; Lucas MC; Nonomiya J; Pang J; Price S; Salphati L; Safina B; Savy PP; Seward EM; Ultsch M; Sutherlin DP
    J Med Chem; 2012 Sep; 55(17):7686-95. PubMed ID: 22877085
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.
    Sutherlin DP; Baker S; Bisconte A; Blaney PM; Brown A; Chan BK; Chantry D; Castanedo G; DePledge P; Goldsmith P; Goldstein DM; Hancox T; Kaur J; Knowles D; Kondru R; Lesnick J; Lucas MC; Lewis C; Murray J; Nadin AJ; Nonomiya J; Pang J; Pegg N; Price S; Reif K; Safina BS; Salphati L; Staben S; Seward EM; Shuttleworth S; Sohal S; Sweeney ZK; Ultsch M; Waszkowycz B; Wei B
    Bioorg Med Chem Lett; 2012 Jul; 22(13):4296-302. PubMed ID: 22672799
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of PI3Kδ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse.
    Suárez-Fueyo A; Rojas JM; Cariaga AE; García E; Steiner BH; Barber DF; Puri KD; Carrera AC
    J Immunol; 2014 Jul; 193(2):544-54. PubMed ID: 24935930
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Advances in the Development of Class I Phosphoinositide 3-Kinase (PI3K) Inhibitors.
    Sabbah DA; Hu J; Zhong HA
    Curr Top Med Chem; 2016; 16(13):1413-26. PubMed ID: 26369826
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and structure-activity relationships of PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives.
    Han F; Lin S; Liu P; Tao J; Yi C; Xu H
    Bioorg Med Chem Lett; 2014 Sep; 24(18):4538-4541. PubMed ID: 25139570
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
    Bui M; Hao X; Shin Y; Cardozo M; He X; Henne K; Suchomel J; McCarter J; McGee LR; San Miguel T; Medina JC; Mohn D; Tran T; Wannberg S; Wong J; Wong S; Zalameda L; Metz D; Cushing TD
    Bioorg Med Chem Lett; 2015 Mar; 25(5):1104-9. PubMed ID: 25666823
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery and biological evaluation of novel pyrazolopyridine derivatives as potent and orally available PI3Kδ inhibitors.
    Hamajima T; Takahashi F; Kato K; Mukoyoshi K; Yoshihara K; Yamaki S; Sugano Y; Moritomo A; Yamagami K; Yokoo K; Fukahori H
    Bioorg Med Chem; 2018 May; 26(9):2410-2419. PubMed ID: 29631787
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.
    Xin M; Duan W; Feng Y; Hei YY; Zhang H; Shen Y; Zhao HY; Mao S; Zhang SQ
    J Enzyme Inhib Med Chem; 2018 Dec; 33(1):651-656. PubMed ID: 29536777
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Simultaneous inhibition of Vps34 kinase would enhance PI3Kδ inhibitor cytotoxicity in the B-cell malignancies.
    Liu X; Wang A; Liang X; Liu J; Zou F; Chen C; Zhao Z; Deng Y; Wu H; Qi Z; Wang B; Wang L; Liu F; Xu Y; Wang W; Fernandes SM; Stone RM; Galinsky IA; Brown JR; Loh T; Griffin JD; Zhang S; Weisberg EL; Zhang X; Liu J; Liu Q
    Oncotarget; 2016 Aug; 7(33):53515-53525. PubMed ID: 27447747
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.
    Safina BS; Sweeney ZK; Li J; Chan BK; Bisconte A; Carrera D; Castanedo G; Flagella M; Heald R; Lewis C; Murray JM; Nonomiya J; Pang J; Price S; Reif K; Salphati L; Seward EM; Wei B; Sutherlin DP
    Bioorg Med Chem Lett; 2013 Sep; 23(17):4953-9. PubMed ID: 23867164
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
    Heffron TP; Heald RA; Ndubaku C; Wei B; Augistin M; Do S; Edgar K; Eigenbrot C; Friedman L; Gancia E; Jackson PS; Jones G; Kolesnikov A; Lee LB; Lesnick JD; Lewis C; McLean N; Mörtl M; Nonomiya J; Pang J; Price S; Prior WW; Salphati L; Sideris S; Staben ST; Steinbacher S; Tsui V; Wallin J; Sampath D; Olivero AG
    J Med Chem; 2016 Feb; 59(3):985-1002. PubMed ID: 26741947
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Small molecule inhibitors of phosphoinositide 3-kinase (PI3K) delta and gamma.
    Ameriks MK; Venable JD
    Curr Top Med Chem; 2009; 9(8):738-53. PubMed ID: 19689378
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-ones based novel, potent and PI3Kδ selective inhibitors.
    Bahekar R; Dave B; Soman S; Patel D; Chopade R; Funde R; Kumar J; Sachchidanand S; Giri P; Chatterjee A; Mahapatra J; Vyas P; Ghoshdastidar K; Bandyopadhyay D; Desai RC
    Bioorg Med Chem Lett; 2019 Jun; 29(11):1313-1319. PubMed ID: 30975623
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.
    Shin Y; Suchomel J; Cardozo M; Duquette J; He X; Henne K; Hu YL; Kelly RC; McCarter J; McGee LR; Medina JC; Metz D; San Miguel T; Mohn D; Tran T; Vissinga C; Wong S; Wannberg S; Whittington DA; Whoriskey J; Yu G; Zalameda L; Zhang X; Cushing TD
    J Med Chem; 2016 Jan; 59(1):431-47. PubMed ID: 26652588
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of new dual spleen tyrosine kinase (Syk) and phosphoionositide-3-kinase δ (PI3Kδ) inhibitors using ligand and structure-based integrated ideal pharmacophore models.
    Kaur M; Silakari O
    SAR QSAR Environ Res; 2016 Jun; 27(6):469-99. PubMed ID: 27431536
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models.
    Dumontet C; Beck G; Gardebien F; Haudecoeur R; Mathé D; Matera EL; Tourette A; Mattei E; Esmenjaud J; Boyère C; Nurisso A; Peuchmaur M; Pérès B; Bouchaud G; Magnan A; Monneret G; Boumendjel A
    Eur J Med Chem; 2018 Oct; 158():405-413. PubMed ID: 30237123
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.