BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

282 related articles for article (PubMed ID: 28212554)

  • 1. AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249.
    Weng MW; Lee HW; Choi B; Wang HT; Hu Y; Mehta M; Desai D; Amin S; Zheng Y; Tang MS
    Oncotarget; 2017 Mar; 8(11):18213-18226. PubMed ID: 28212554
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts.
    Denissenko MF; Koudriakova TB; Smith L; O'Connor TR; Riggs AD; Pfeifer GP
    Oncogene; 1998 Dec; 17(23):3007-14. PubMed ID: 9881702
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hepatic aflatoxin B1-DNA adducts and TP53 mutations in patients with hepatocellular carcinoma despite low exposure to aflatoxin B1 in southern Japan.
    Shirabe K; Toshima T; Taketomi A; Taguchi K; Yoshizumi T; Uchiyama H; Harimoto N; Kajiyama K; Egashira A; Maehara Y
    Liver Int; 2011 Oct; 31(9):1366-72. PubMed ID: 21745313
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The p53 mutation spectrum in hepatocellular carcinoma from Guangxi, China : role of chronic hepatitis B virus infection and aflatoxin B1 exposure.
    Qi LN; Bai T; Chen ZS; Wu FX; Chen YY; De Xiang B; Peng T; Han ZG; Li LQ
    Liver Int; 2015 Mar; 35(3):999-1009. PubMed ID: 24461059
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.
    Aguilar F; Hussain SP; Cerutti P
    Proc Natl Acad Sci U S A; 1993 Sep; 90(18):8586-90. PubMed ID: 8397412
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis.
    Shen HM; Ong CN
    Mutat Res; 1996 Oct; 366(1):23-44. PubMed ID: 8921985
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma.
    Hu W; Feng Z; Eveleigh J; Iyer G; Pan J; Amin S; Chung FL; Tang MS
    Carcinogenesis; 2002 Nov; 23(11):1781-9. PubMed ID: 12419825
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mutational spectra of aflatoxin B
    Chawanthayatham S; Valentine CC; Fedeles BI; Fox EJ; Loeb LA; Levine SS; Slocum SL; Wogan GN; Croy RG; Essigmann JM
    Proc Natl Acad Sci U S A; 2017 Apr; 114(15):E3101-E3109. PubMed ID: 28351974
    [TBL] [Abstract][Full Text] [Related]  

  • 9. p53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan.
    Lunn RM; Zhang YJ; Wang LY; Chen CJ; Lee PH; Lee CS; Tsai WY; Santella RM
    Cancer Res; 1997 Aug; 57(16):3471-7. PubMed ID: 9270015
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines.
    Macé K; Aguilar F; Wang JS; Vautravers P; Gómez-Lechón M; Gonzalez FJ; Groopman J; Harris CC; Pfeifer AM
    Carcinogenesis; 1997 Jul; 18(7):1291-7. PubMed ID: 9230270
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation.
    Chung FL; Pan J; Choudhury S; Roy R; Hu W; Tang MS
    Mutat Res; 2003 Oct; 531(1-2):25-36. PubMed ID: 14637245
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells.
    Feng Z; Hu W; Amin S; Tang MS
    Biochemistry; 2003 Jul; 42(25):7848-54. PubMed ID: 12820894
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1.
    Park US; Su JJ; Ban KC; Qin L; Lee EH; Lee YI
    Gene; 2000 Jun; 251(1):73-80. PubMed ID: 10863098
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1.
    McGlynn KA; Rosvold EA; Lustbader ED; Hu Y; Clapper ML; Zhou T; Wild CP; Xia XL; Baffoe-Bonnie A; Ofori-Adjei D
    Proc Natl Acad Sci U S A; 1995 Mar; 92(6):2384-7. PubMed ID: 7892276
    [TBL] [Abstract][Full Text] [Related]  

  • 15. DNA damage checkpoint response to aflatoxin B1.
    Engin AB; Engin A
    Environ Toxicol Pharmacol; 2019 Jan; 65():90-96. PubMed ID: 30594067
    [TBL] [Abstract][Full Text] [Related]  

  • 16. An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico.
    Soini Y; Chia SC; Bennett WP; Groopman JD; Wang JS; DeBenedetti VM; Cawley H; Welsh JA; Hansen C; Bergasa NV; Jones EA; DiBisceglie AM; Trivers GE; Sandoval CA; Calderon IE; Munoz Espinosa LE; Harris CC
    Carcinogenesis; 1996 May; 17(5):1007-12. PubMed ID: 8640905
    [TBL] [Abstract][Full Text] [Related]  

  • 17. DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure.
    Lin YC; Owen N; Minko IG; Lange SS; Tomida J; Li L; Stone MP; Wood RD; McCullough AK; Lloyd RS
    Proc Natl Acad Sci U S A; 2016 Nov; 113(48):13774-13779. PubMed ID: 27849610
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Geographic variation of p53 mutational profile in nonmalignant human liver.
    Aguilar F; Harris CC; Sun T; Hollstein M; Cerutti P
    Science; 1994 May; 264(5163):1317-9. PubMed ID: 8191284
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence.
    Cho YJ; Wang H; Kozekov ID; Kurtz AJ; Jacob J; Voehler M; Smith J; Harris TM; Lloyd RS; Rizzo CJ; Stone MP
    Chem Res Toxicol; 2006 Feb; 19(2):195-208. PubMed ID: 16485895
    [TBL] [Abstract][Full Text] [Related]  

  • 20. An intercalation inhibitor altering the target selectivity of DNA damaging agents: synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot.
    Kobertz WR; Wang D; Wogan GN; Essigmann JM
    Proc Natl Acad Sci U S A; 1997 Sep; 94(18):9579-84. PubMed ID: 9275165
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.