BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

387 related articles for article (PubMed ID: 28223512)

  • 1. Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.
    Sardi SP; Viel C; Clarke J; Treleaven CM; Richards AM; Park H; Olszewski MA; Dodge JC; Marshall J; Makino E; Wang B; Sidman RL; Cheng SH; Shihabuddin LS
    Proc Natl Acad Sci U S A; 2017 Mar; 114(10):2699-2704. PubMed ID: 28223512
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model.
    Viel C; Clarke J; Kayatekin C; Richards AM; Chiang MSR; Park H; Wang B; Shihabuddin LS; Sardi SP
    Sci Rep; 2021 Oct; 11(1):20945. PubMed ID: 34686711
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies.
    Sardi SP; Clarke J; Viel C; Chan M; Tamsett TJ; Treleaven CM; Bu J; Sweet L; Passini MA; Dodge JC; Yu WH; Sidman RL; Cheng SH; Shihabuddin LS
    Proc Natl Acad Sci U S A; 2013 Feb; 110(9):3537-42. PubMed ID: 23297226
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.
    Fishbein I; Kuo YM; Giasson BI; Nussbaum RL
    Brain; 2014 Dec; 137(Pt 12):3235-47. PubMed ID: 25351739
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.
    Rockenstein E; Clarke J; Viel C; Panarello N; Treleaven CM; Kim C; Spencer B; Adame A; Park H; Dodge JC; Cheng SH; Shihabuddin LS; Masliah E; Sardi SP
    Hum Mol Genet; 2016 Jul; 25(13):2645-2660. PubMed ID: 27126635
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
    Cosden M; Jinn S; Yao L; Gretzula CA; Kandebo M; Toolan D; Hatcher NG; Ma L; Lemaire W; Adam GC; Burlein C; Minnick C; Flick R; Watt ML; Mulhearn J; Fraley M; Drolet RE; Marcus JN; Smith SM
    Neurobiol Dis; 2021 Nov; 159():105507. PubMed ID: 34509608
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease.
    Taguchi YV; Liu J; Ruan J; Pacheco J; Zhang X; Abbasi J; Keutzer J; Mistry PK; Chandra SS
    J Neurosci; 2017 Oct; 37(40):9617-9631. PubMed ID: 28847804
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course.
    Tayebi N; Parisiadou L; Berhe B; Gonzalez AN; Serra-Vinardell J; Tamargo RJ; Maniwang E; Sorrentino Z; Fujiwara H; Grey RJ; Hassan S; Blech-Hermoni YN; Chen C; McGlinchey R; Makariou-Pikis C; Brooks M; Ginns EI; Ory DS; Giasson BI; Sidransky E
    Mol Genet Metab; 2017 Dec; 122(4):198-208. PubMed ID: 29173981
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The association between lysosomal protein glucocerebrosidase and Parkinson's disease.
    Kong B; Yang T; Gu JW; Kuang YQ; Cheng L; Yang WT; Yang XK; Xia X; Cheng JM; Ma Y; Zhang JH; Yu SX
    Eur Rev Med Pharmacol Sci; 2013 Jan; 17(2):143-51. PubMed ID: 23377801
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.
    Price DL; Koike MA; Khan A; Wrasidlo W; Rockenstein E; Masliah E; Bonhaus D
    Sci Rep; 2018 Nov; 8(1):16165. PubMed ID: 30385782
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy.
    Sardi SP; Clarke J; Kinnecom C; Tamsett TJ; Li L; Stanek LM; Passini MA; Grabowski GA; Schlossmacher MG; Sidman RL; Cheng SH; Shihabuddin LS
    Proc Natl Acad Sci U S A; 2011 Jul; 108(29):12101-6. PubMed ID: 21730160
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice.
    Johnson ME; Bergkvist L; Stetzik L; Steiner JA; Meyerdirk L; Schulz E; Wolfrum E; Luk KC; Wesson DW; Krainc D; Brundin P
    Neurobiol Dis; 2021 Nov; 159():105513. PubMed ID: 34536552
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.
    Rocha EM; Smith GA; Park E; Cao H; Graham AR; Brown E; McLean JR; Hayes MA; Beagan J; Izen SC; Perez-Torres E; Hallett PJ; Isacson O
    Antioxid Redox Signal; 2015 Aug; 23(6):550-64. PubMed ID: 26094487
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Double-Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α-Synuclein.
    Schidlitzki A; Stanojlovic M; Fournier C; Käufer C; Feja M; Gericke B; Garzotti M; Welford RWD; Steiner MA; Angot E; Richter F
    Mov Disord; 2023 Jun; 38(6):1044-1055. PubMed ID: 37050861
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.
    Henderson MX; Sedor S; McGeary I; Cornblath EJ; Peng C; Riddle DM; Li HL; Zhang B; Brown HJ; Olufemi MF; Bassett DS; Trojanowski JQ; Lee VMY
    Neuron; 2020 Mar; 105(5):822-836.e7. PubMed ID: 31899072
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Behavioral Phenotyping in a Murine Model of
    Do J; Perez G; Berhe B; Tayebi N; Sidransky E
    Int J Mol Sci; 2021 Jun; 22(13):. PubMed ID: 34202076
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.
    Tatenhorst L; Eckermann K; Dambeck V; Fonseca-Ornelas L; Walle H; Lopes da Fonseca T; Koch JC; Becker S; Tönges L; Bähr M; Outeiro TF; Zweckstetter M; Lingor P
    Acta Neuropathol Commun; 2016 Apr; 4():39. PubMed ID: 27101974
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease.
    Marshall J; Sun Y; Bangari DS; Budman E; Park H; Nietupski JB; Allaire A; Cromwell MA; Wang B; Grabowski GA; Leonard JP; Cheng SH
    Mol Ther; 2016 Jun; 24(6):1019-1029. PubMed ID: 26948439
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance.
    Blanz J; Saftig P
    J Neurochem; 2016 Oct; 139 Suppl 1():198-215. PubMed ID: 26860955
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Advances in GBA-associated Parkinson's disease--Pathology, presentation and therapies.
    Barkhuizen M; Anderson DG; Grobler AF
    Neurochem Int; 2016 Feb; 93():6-25. PubMed ID: 26743617
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.