These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

142 related articles for article (PubMed ID: 28229434)

  • 1. Preclinical Pharmacokinetics and Pharmacodynamics of Pinometostat (EPZ-5676), a First-in-Class, Small Molecule S-Adenosyl Methionine Competitive Inhibitor of DOT1L.
    Waters NJ
    Eur J Drug Metab Pharmacokinet; 2017 Dec; 42(6):891-901. PubMed ID: 28229434
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target.
    Waters NJ; Daigle SR; Rehlaender BN; Basavapathruni A; Campbell CT; Jensen TB; Truitt BF; Olhava EJ; Pollock RM; Stickland KA; Dovletoglou A
    J Control Release; 2015 Dec; 220(Pt B):758-65. PubMed ID: 26385168
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
    Stein EM; Garcia-Manero G; Rizzieri DA; Tibes R; Berdeja JG; Savona MR; Jongen-Lavrenic M; Altman JK; Thomson B; Blakemore SJ; Daigle SR; Waters NJ; Suttle AB; Clawson A; Pollock R; Krivtsov A; Armstrong SA; DiMartino J; Hedrick E; Löwenberg B; Tallman MS
    Blood; 2018 Jun; 131(24):2661-2669. PubMed ID: 29724899
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The DOT1L inhibitor Pinometostat decreases the host-response against infections: Considerations about its use in human therapy.
    Marcos-Villar L; Nieto A
    Sci Rep; 2019 Nov; 9(1):16862. PubMed ID: 31727944
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in
    Campbell CT; Haladyna JN; Drubin DA; Thomson TM; Maria MJ; Yamauchi T; Waters NJ; Olhava EJ; Pollock RM; Smith JJ; Copeland RA; Blakemore SJ; Bernt KM; Daigle SR
    Mol Cancer Ther; 2017 Aug; 16(8):1669-1679. PubMed ID: 28428443
    [TBL] [Abstract][Full Text] [Related]  

  • 6. DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment.
    Sarno F; Nebbioso A; Altucci L
    Epigenetics; 2020 May; 15(5):439-453. PubMed ID: 31790636
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.
    Daigle SR; Olhava EJ; Therkelsen CA; Basavapathruni A; Jin L; Boriack-Sjodin PA; Allain CJ; Klaus CR; Raimondi A; Scott MP; Waters NJ; Chesworth R; Moyer MP; Copeland RA; Richon VM; Pollock RM
    Blood; 2013 Aug; 122(6):1017-25. PubMed ID: 23801631
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.
    Basavapathruni A; Olhava EJ; Daigle SR; Therkelsen CA; Jin L; Boriack-Sjodin PA; Allain CJ; Klaus CR; Raimondi A; Scott MP; Dovletoglou A; Richon VM; Pollock RM; Copeland RA; Moyer MP; Chesworth R; Pearson PG; Waters NJ
    Biopharm Drug Dispos; 2014 May; 35(4):237-52. PubMed ID: 24415392
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human.
    Waters NJ; Smith SA; Olhava EJ; Duncan KW; Burton RD; O'Neill J; Rodrigue ME; Pollock RM; Moyer MP; Chesworth R
    Cancer Chemother Pharmacol; 2016 Jan; 77(1):43-62. PubMed ID: 26645404
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia.
    Barve A; Vega A; Shah PP; Ghare S; Casson L; Wunderlich M; Siskind LJ; Beverly LJ
    Cells; 2019 Oct; 8(11):. PubMed ID: 31717699
    [TBL] [Abstract][Full Text] [Related]  

  • 11. [Mechanism of A New DOT1L Inhibitor EPZ-5676 and Its Research Progress -Review].
    Li LH; Wang J; Ke XY
    Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2016 Dec; 24(6):1909-1912. PubMed ID: 28024519
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias.
    Yi Y; Ge S
    J Hematol Oncol; 2022 Mar; 15(1):35. PubMed ID: 35331314
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein.
    Bon C; Si Y; Pernak M; Barbachowska M; Levi-Acobas E; Cadet Daniel V; Jallet C; Ruzic D; Djokovic N; Djikić T; Nikolic K; Halby L; Arimondo PB
    Molecules; 2021 Aug; 26(17):. PubMed ID: 34500733
    [TBL] [Abstract][Full Text] [Related]  

  • 14. DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.
    Klaus CR; Iwanowicz D; Johnston D; Campbell CA; Smith JJ; Moyer MP; Copeland RA; Olhava EJ; Scott MP; Pollock RM; Daigle SR; Raimondi A
    J Pharmacol Exp Ther; 2014 Sep; 350(3):646-56. PubMed ID: 24993360
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of Methyltransferase DOT1L Sensitizes to Sorafenib Treatment AML Cells Irrespective of
    Lonetti A; Indio V; Laginestra MA; Tarantino G; Chiarini F; Astolfi A; Bertuccio SN; Martelli AM; Locatelli F; Pession A; Masetti R
    Cancers (Basel); 2020 Jul; 12(7):. PubMed ID: 32698374
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Computer-Aided Discovery of Massonianoside B as a Novel Selective DOT1L Inhibitor.
    Chen J; Park HJ
    ACS Chem Biol; 2019 May; 14(5):873-881. PubMed ID: 30951287
    [TBL] [Abstract][Full Text] [Related]  

  • 17. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
    Chen CW; Koche RP; Sinha AU; Deshpande AJ; Zhu N; Eng R; Doench JG; Xu H; Chu SH; Qi J; Wang X; Delaney C; Bernt KM; Root DE; Hahn WC; Bradner JE; Armstrong SA
    Nat Med; 2015 Apr; 21(4):335-43. PubMed ID: 25822366
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development.
    Barry ER; Corry GN; Rasmussen TP
    Expert Opin Ther Targets; 2010 Apr; 14(4):405-18. PubMed ID: 20230194
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mixed lineage rearranged leukaemia: pathogenesis and targeting DOT1L.
    Stein EM; Tallman MS
    Curr Opin Hematol; 2015 Mar; 22(2):92-6. PubMed ID: 25635757
    [TBL] [Abstract][Full Text] [Related]  

  • 20. DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation.
    Godfrey L; Crump NT; Thorne R; Lau IJ; Repapi E; Dimou D; Smith AL; Harman JR; Telenius JM; Oudelaar AM; Downes DJ; Vyas P; Hughes JR; Milne TA
    Nat Commun; 2019 Jun; 10(1):2803. PubMed ID: 31243293
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.