126 related articles for article (PubMed ID: 28245091)
1. SYN-004 (ribaxamase), an oral beta-lactamase, mitigates antibiotic-mediated dysbiosis in a porcine gut microbiome model.
Connelly S; Bristol JA; Hubert S; Subramanian P; Hasan NA; Colwell RR; Kaleko M
J Appl Microbiol; 2017 Jul; 123(1):66-79. PubMed ID: 28245091
[TBL] [Abstract][Full Text] [Related]
2. Oral Metallo-Beta-Lactamase Protects the Gut Microbiome From Carbapenem-Mediated Damage and Reduces Propagation of Antibiotic Resistance in Pigs.
Connelly S; Fanelli B; Hasan NA; Colwell RR; Kaleko M
Front Microbiol; 2019; 10():101. PubMed ID: 30804903
[TBL] [Abstract][Full Text] [Related]
3. Oral Beta-Lactamase Protects the Canine Gut Microbiome from Oral Amoxicillin-Mediated Damage.
Connelly S; Fanelli B; Hasan NA; Colwell RR; Kaleko M
Microorganisms; 2019 May; 7(5):. PubMed ID: 31137766
[TBL] [Abstract][Full Text] [Related]
4. SYN-007, an Orally Administered Beta-Lactamase Enzyme, Protects the Gut Microbiome from Oral Amoxicillin/Clavulanate without Adversely Affecting Antibiotic Systemic Absorption in Dogs.
Connelly S; Fanelli B; Hasan NA; Colwell RR; Kaleko M
Microorganisms; 2020 Jan; 8(2):. PubMed ID: 31979034
[TBL] [Abstract][Full Text] [Related]
5. The Oral β-Lactamase SYN-004 (Ribaxamase) Degrades Ceftriaxone Excreted into the Intestine in Phase 2a Clinical Studies.
Kokai-Kun JF; Roberts T; Coughlin O; Sicard E; Rufiange M; Fedorak R; Carter C; Adams MH; Longstreth J; Whalen H; Sliman J
Antimicrob Agents Chemother; 2017 Mar; 61(3):. PubMed ID: 28052855
[TBL] [Abstract][Full Text] [Related]
6. Ribaxamase, an Orally Administered β-Lactamase, Diminishes Changes to Acquired Antimicrobial Resistance of the Gut Resistome in Patients Treated with Ceftriaxone.
Kokai-Kun JF; Le C; Trout K; Cope JL; Ajami NJ; Degar AJ; Connelly S
Infect Drug Resist; 2020; 13():2521-2535. PubMed ID: 32801790
[TBL] [Abstract][Full Text] [Related]
7. Low dose oral beta-lactamase protects the gut microbiome from oral beta-lactam-mediated damage in dogs.
Connelly S; Fanelli B; Hasan NA; Colwell RR; Kaleko M
AIMS Public Health; 2019; 6(4):477-487. PubMed ID: 31909068
[TBL] [Abstract][Full Text] [Related]
8. Identification, Characterization, and Formulation of a Novel Carbapenemase Intended to Prevent Antibiotic-Mediated Gut Dysbiosis.
Connelly S; Parsley T; Ge H; Kaleko M
Microorganisms; 2019 Jan; 7(1):. PubMed ID: 30654495
[TBL] [Abstract][Full Text] [Related]
9. Use of ribaxamase (SYN-004), a β-lactamase, to prevent Clostridium difficile infection in β-lactam-treated patients: a double-blind, phase 2b, randomised placebo-controlled trial.
Kokai-Kun JF; Roberts T; Coughlin O; Le C; Whalen H; Stevenson R; Wacher VJ; Sliman J
Lancet Infect Dis; 2019 May; 19(5):487-496. PubMed ID: 30885591
[TBL] [Abstract][Full Text] [Related]
10. Development of SYN-004, an oral beta-lactamase treatment to protect the gut microbiome from antibiotic-mediated damage and prevent Clostridium difficile infection.
Kaleko M; Bristol JA; Hubert S; Parsley T; Widmer G; Tzipori S; Subramanian P; Hasan N; Koski P; Kokai-Kun J; Sliman J; Jones A; Connelly S
Anaerobe; 2016 Oct; 41():58-67. PubMed ID: 27262694
[TBL] [Abstract][Full Text] [Related]
11. Distinct consequences of amoxicillin and ertapenem exposure in the porcine gut microbiome.
Connelly S; Subramanian P; Hasan NA; Colwell RR; Kaleko M
Anaerobe; 2018 Oct; 53():82-93. PubMed ID: 29689301
[TBL] [Abstract][Full Text] [Related]
12. Formulation development of SYN-004 (ribaxamase) oral solid dosage form, a β-lactamase to prevent intravenous antibiotic-associated dysbiosis of the colon.
Bristol A; Hubert S; Hofmann F; Baer H
Int J Pharm; 2017 Dec; 534(1-2):25-34. PubMed ID: 28986322
[TBL] [Abstract][Full Text] [Related]
13. Nonclinical Safety Assessment of SYN-004: An Oral β-lactamase for the Protection of the Gut Microbiome From Disruption by Biliary-Excreted, Intravenously Administered Antibiotics.
Kokai-Kun JF; Bristol JA; Setser J; Schlosser M
Int J Toxicol; 2016 May; 35(3):309-16. PubMed ID: 26700136
[TBL] [Abstract][Full Text] [Related]
14. Effects of Antibiotic Treatment with Piperacillin/Tazobactam versus Ceftriaxone on the Composition of the Murine Gut Microbiota.
Venturini C; Bowring B; Fajardo-Lubian A; Devine C; Iredell J
Antimicrob Agents Chemother; 2021 Jan; 65(2):. PubMed ID: 33168609
[TBL] [Abstract][Full Text] [Related]
15. Characterization of the Pig Gut Microbiome and Antibiotic Resistome in Industrialized Feedlots in China.
Wang C; Li P; Yan Q; Chen L; Li T; Zhang W; Li H; Chen C; Han X; Zhang S; Xu M; Li B; Zhang X; Ni H; Ma Y; Dong B; Li S; Liu S
mSystems; 2019 Dec; 4(6):. PubMed ID: 31848308
[TBL] [Abstract][Full Text] [Related]
16. Partial recovery of microbiomes after antibiotic treatment.
Raymond F; Déraspe M; Boissinot M; Bergeron MG; Corbeil J
Gut Microbes; 2016 Sep; 7(5):428-34. PubMed ID: 27494088
[TBL] [Abstract][Full Text] [Related]
17. Tolerability and Pharmacokinetics of SYN-004, an Orally Administered β-Lactamase for the Prevention of Clostridium difficile-Associated Disease and Antibiotic-Associated Diarrhea, in Two Phase 1 Studies.
Roberts T; Kokai-Kun JF; Coughlin O; Lopez BV; Whalen H; Bristol JA; Hubert S; Longstreth J; Lasseter K; Sliman J
Clin Drug Investig; 2016 Sep; 36(9):725-734. PubMed ID: 27283946
[TBL] [Abstract][Full Text] [Related]
18. The initial state of the human gut microbiome determines its reshaping by antibiotics.
Raymond F; Ouameur AA; Déraspe M; Iqbal N; Gingras H; Dridi B; Leprohon P; Plante PL; Giroux R; Bérubé È; Frenette J; Boudreau DK; Simard JL; Chabot I; Domingo MC; Trottier S; Boissinot M; Huletsky A; Roy PH; Ouellette M; Bergeron MG; Corbeil J
ISME J; 2016 Mar; 10(3):707-20. PubMed ID: 26359913
[TBL] [Abstract][Full Text] [Related]
19. Gut Dysbiosis in Animals Due to Environmental Chemical Exposures.
Rosenfeld CS
Front Cell Infect Microbiol; 2017; 7():396. PubMed ID: 28936425
[TBL] [Abstract][Full Text] [Related]
20. Demystifying Dysbiosis: Can the Gut Microbiome Promote Oral Tolerance Over IgE-mediated Food Allergy?
Marrs T; Sim K
Curr Pediatr Rev; 2018; 14(3):156-163. PubMed ID: 29732975
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
