173 related articles for article (PubMed ID: 28258797)
1. Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Zaware N; Kisliuk R; Bastian A; Ihnat MA; Gangjee A
Bioorg Med Chem Lett; 2017 Apr; 27(7):1602-1607. PubMed ID: 28258797
[TBL] [Abstract][Full Text] [Related]
2. Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Gangjee A; Zaware N; Raghavan S; Ihnat M; Shenoy S; Kisliuk RL
J Med Chem; 2010 Feb; 53(4):1563-78. PubMed ID: 20092323
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological activity of 5-chloro-N⁴-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.
Gangjee A; Zaware N; Raghavan S; Disch BC; Thorpe JE; Bastian A; Ihnat MA
Bioorg Med Chem; 2013 Apr; 21(7):1857-64. PubMed ID: 23434139
[TBL] [Abstract][Full Text] [Related]
4. Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity.
Gangjee A; Zeng Y; Ihnat M; Warnke LA; Green DW; Kisliuk RL; Lin FT
Bioorg Med Chem; 2005 Sep; 13(18):5475-91. PubMed ID: 16039863
[TBL] [Abstract][Full Text] [Related]
5. Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.
Gangjee A; Namjoshi OA; Yu J; Ihnat MA; Thorpe JE; Warnke LA
Bioorg Med Chem; 2008 May; 16(10):5514-28. PubMed ID: 18467105
[TBL] [Abstract][Full Text] [Related]
6. Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases.
Gangjee A; Yang J; Ihnat MA; Kamat S
Bioorg Med Chem; 2003 Nov; 11(23):5155-70. PubMed ID: 14604679
[TBL] [Abstract][Full Text] [Related]
7. Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.
Gangjee A; Jain HD; Kisliuk RL
Bioorg Med Chem Lett; 2005 May; 15(9):2225-30. PubMed ID: 15837298
[TBL] [Abstract][Full Text] [Related]
8. Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.
Pavana RK; Choudhary S; Bastian A; Ihnat MA; Bai R; Hamel E; Gangjee A
Bioorg Med Chem; 2017 Jan; 25(2):545-556. PubMed ID: 27894589
[TBL] [Abstract][Full Text] [Related]
9. Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).
Gangjee A; Jain HD; Phan J; Lin X; Song X; McGuire JJ; Kisliuk RL
J Med Chem; 2006 Feb; 49(3):1055-65. PubMed ID: 16451071
[TBL] [Abstract][Full Text] [Related]
10. The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Zhang X; Raghavan S; Ihnat M; Hamel E; Zammiello C; Bastian A; Mooberry SL; Gangjee A
Bioorg Med Chem; 2015 May; 23(10):2408-23. PubMed ID: 25882519
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents.
Gangjee A; Zhao Y; Raghavan S; Ihnat MA; Disch BC
Bioorg Med Chem; 2010 Jul; 18(14):5261-73. PubMed ID: 20558072
[TBL] [Abstract][Full Text] [Related]
12. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity.
Patyna S; Laird AD; Mendel DB; O'farrell AM; Liang C; Guan H; Vojkovsky T; Vasile S; Wang X; Chen J; Grazzini M; Yang CY; Haznedar JO; Sukbuntherng J; Zhong WZ; Cherrington JM; Hu-Lowe D
Mol Cancer Ther; 2006 Jul; 5(7):1774-82. PubMed ID: 16891463
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis.
Liu Y; Zhang C; Zhang H; Li M; Yuan J; Zhang Y; Zhou J; Guo H; Zhao L; Du Y; Wang L; Ren L
Eur J Med Chem; 2015 Mar; 93():142-55. PubMed ID: 25668494
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis and preclinical evaluation of 5-methyl-N
Devambatla RKV; Choudhary S; Ihnat M; Hamel E; Mooberry SL; Gangjee A
Bioorg Med Chem Lett; 2018 Oct; 28(18):3085-3093. PubMed ID: 30098869
[TBL] [Abstract][Full Text] [Related]
15. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
Gangjee A; Lin X; Kisliuk RL; McGuire JJ
J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780
[TBL] [Abstract][Full Text] [Related]
16. 5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents.
Gangjee A; Devraj R; McGuire JJ; Kisliuk RL
J Med Chem; 1995 Oct; 38(22):4495-502. PubMed ID: 7473577
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.
Gangjee A; Kurup S; Ihnat MA; Thorpe JE; Shenoy SS
Bioorg Med Chem; 2010 May; 18(10):3575-87. PubMed ID: 20403700
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents.
Tian C; Wang M; Han Z; Fang F; Zhang Z; Wang X; Liu J
Eur J Med Chem; 2017 Sep; 138():630-643. PubMed ID: 28711701
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents.
Liu Y; Li M; Zhang H; Yuan J; Zhang C; Zhang K; Guo H; Zhao L; Du Y; Wang L; Ren L
Eur J Med Chem; 2016 Jun; 115():245-56. PubMed ID: 27017552
[TBL] [Abstract][Full Text] [Related]
20. N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Gangjee A; Zaware N; Raghavan S; Yang J; Thorpe JE; Ihnat MA
Bioorg Med Chem; 2012 Apr; 20(7):2444-54. PubMed ID: 22370340
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
