BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

151 related articles for article (PubMed ID: 28296564)

  • 21. A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.
    Matheson CJ; Venkataraman S; Amani V; Harris PS; Backos DS; Donson AM; Wempe MF; Foreman NK; Vibhakar R; Reigan P
    ACS Chem Biol; 2016 Apr; 11(4):921-30. PubMed ID: 26745241
    [TBL] [Abstract][Full Text] [Related]  

  • 22. PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer.
    Brunner A; Suryo Rahmanto A; Johansson H; Franco M; Viiliäinen J; Gazi M; Frings O; Fredlund E; Spruck C; Lehtiö J; Rantala JK; Larsson LG; Sangfelt O
    Elife; 2020 Jul; 9():. PubMed ID: 32628111
    [TBL] [Abstract][Full Text] [Related]  

  • 23. WEE1 inhibitor, AZD1775, overcomes trastuzumab resistance by targeting cancer stem-like properties in HER2-positive breast cancer.
    Sand A; Piacsek M; Donohoe DL; Duffin AT; Riddell GT; Sun C; Tang M; Rovin RA; Tjoe JA; Yin J
    Cancer Lett; 2020 Mar; 472():119-131. PubMed ID: 31866466
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk
    Tanaka N; Patel AA; Tang L; Silver NL; Lindemann A; Takahashi H; Jaksik R; Rao X; Kalu NN; Chen TC; Wang J; Frederick MJ; Johnson F; Gleber-Netto FO; Fu S; Kimmel M; Wang J; Hittelman WN; Pickering CR; Myers JN; Osman AA
    Clin Cancer Res; 2017 Nov; 23(21):6541-6554. PubMed ID: 28790110
    [No Abstract]   [Full Text] [Related]  

  • 25. DNA-dependent protein kinase: effect on DSB repair, G2/M checkpoint and mode of cell death in NSCLC cell lines.
    Sak A; Groneberg M; Stuschke M
    Int J Radiat Biol; 2019 Sep; 95(9):1205-1219. PubMed ID: 31287365
    [No Abstract]   [Full Text] [Related]  

  • 26. Wee1 Inhibitor AZD1775 Combined with Cisplatin Potentiates Anticancer Activity against Gastric Cancer by Increasing DNA Damage and Cell Apoptosis.
    Chen D; Lin X; Gao J; Shen L; Li Z; Dong B; Zhang C; Zhang X
    Biomed Res Int; 2018; 2018():5813292. PubMed ID: 29977914
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.
    Webster PJ; Littlejohns AT; Gaunt HJ; Young RS; Rode B; Ritchie JE; Stead LF; Harrison S; Droop A; Martin HL; Tomlinson DC; Hyman AJ; Appleby HL; Boxall S; Bruns AF; Li J; Prasad RK; Lodge JPA; Burke DA; Beech DJ
    Oncotarget; 2017 Jun; 8(26):42288-42299. PubMed ID: 28178688
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Development of Potent Pyrazolopyrimidinone-Based WEE1 Inhibitors with Limited Single-Agent Cytotoxicity for Cancer Therapy.
    Matheson CJ; Casalvieri KA; Backos DS; Reigan P
    ChemMedChem; 2018 Aug; 13(16):1681-1694. PubMed ID: 29883531
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Pharmacological Inhibition of WEE1 Potentiates the Antitumoral Effect of the
    Iannuzzi CA; Indovina P; Forte IM; Di Somma S; Malfitano AM; Bruno M; Portella G; Pentimalli F; Giordano A
    Int J Mol Sci; 2020 Oct; 21(19):. PubMed ID: 33020398
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Development and Characterization of a Wee1 Kinase Degrader.
    Li Z; Pinch BJ; Olson CM; Donovan KA; Nowak RP; Mills CE; Scott DA; Doctor ZM; Eleuteri NA; Chung M; Sorger PK; Fischer ES; Gray NS
    Cell Chem Biol; 2020 Jan; 27(1):57-65.e9. PubMed ID: 31735695
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells.
    Wen C; Chen J; Zhang D; Wang H; Che J; Qin Q; He L; Cai Z; Lin M; Lou Q; Huang L; Chen D; Iwamoto A; Ren D; Wang L; Lan P; Wang J; Liu H; Yang X
    Cancer Lett; 2016 Dec; 383(2):295-308. PubMed ID: 27713084
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil.
    Dörsam B; Göder A; Seiwert N; Kaina B; Fahrer J
    Arch Toxicol; 2015 Oct; 89(10):1829-46. PubMed ID: 25526924
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Wee1 inhibition can suppress tumor proliferation and sensitize p53 mutant colonic cancer cells to the anticancer effect of irinotecan.
    Yin Y; Shen Q; Tao R; Chang W; Li R; Xie G; Liu W; Zhang P; Tao K
    Mol Med Rep; 2018 Feb; 17(2):3344-3349. PubMed ID: 29257266
    [TBL] [Abstract][Full Text] [Related]  

  • 34. PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors.
    Parsels LA; Karnak D; Parsels JD; Zhang Q; Vélez-Padilla J; Reichert ZR; Wahl DR; Maybaum J; O'Connor MJ; Lawrence TS; Morgan MA
    Mol Cancer Res; 2018 Feb; 16(2):222-232. PubMed ID: 29133592
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months.
    Leijen S; van Geel RM; Sonke GS; de Jong D; Rosenberg EH; Marchetti S; Pluim D; van Werkhoven E; Rose S; Lee MA; Freshwater T; Beijnen JH; Schellens JH
    J Clin Oncol; 2016 Dec; 34(36):4354-4361. PubMed ID: 27998224
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301.
    Chopra A; Bond MJ; Bleiler M; Yeagley M; Wright D; Giardina C
    PLoS One; 2016; 11(4):e0153818. PubMed ID: 27097159
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells.
    Yun HJ; Hyun SK; Park JH; Kim BW; Kwon HJ
    Mol Cell Biochem; 2012 Apr; 363(1-2):281-9. PubMed ID: 22160829
    [TBL] [Abstract][Full Text] [Related]  

  • 38. WEE1 Inhibitor: Clinical Development.
    Kong A; Mehanna H
    Curr Oncol Rep; 2021 Jul; 23(9):107. PubMed ID: 34269904
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin.
    Wiegering A; Matthes N; Mühling B; Koospal M; Quenzer A; Peter S; Germer CT; Linnebacher M; Otto C
    Neoplasia; 2017 Apr; 19(4):301-309. PubMed ID: 28284059
    [TBL] [Abstract][Full Text] [Related]  

  • 40. 53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM-CHK2-P53 pathway.
    Yao J; Huang A; Zheng X; Liu T; Lin Z; Zhang S; Yang Q; Zhang T; Ma H
    J Cancer Res Clin Oncol; 2017 Mar; 143(3):419-431. PubMed ID: 27838786
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.