These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

265 related articles for article (PubMed ID: 28299790)

  • 21. Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.
    Faisal A; Mak GWY; Gurden MD; Xavier CPR; Anderhub SJ; Innocenti P; Westwood IM; Naud S; Hayes A; Box G; Valenti MR; De Haven Brandon AK; O'Fee L; Schmitt J; Woodward HL; Burke R; vanMontfort RLM; Blagg J; Raynaud FI; Eccles SA; Hoelder S; Linardopoulos S
    Br J Cancer; 2017 Apr; 116(9):1166-1176. PubMed ID: 28334731
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Novel Mps1 kinase inhibitors: from purine to pyrrolopyrimidine and quinazoline leads.
    Bursavich MG; Dastrup D; Shenderovich M; Yager KM; Cimbora DM; Williams B; Kumar DV
    Bioorg Med Chem Lett; 2013 Dec; 23(24):6829-33. PubMed ID: 24183538
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis.
    Sliedrecht T; Zhang C; Shokat KM; Kops GJ
    PLoS One; 2010 Apr; 5(4):e10251. PubMed ID: 20422024
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer.
    Sugimoto Y; Sawant DB; Fisk HA; Mao L; Li C; Chettiar S; Li PK; Darby MV; Brueggemeier RW
    Bioorg Med Chem; 2017 Apr; 25(7):2156-2166. PubMed ID: 28259529
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Molecular basis underlying resistance to Mps1/TTK inhibitors.
    Koch A; Maia A; Janssen A; Medema RH
    Oncogene; 2016 May; 35(19):2518-28. PubMed ID: 26364596
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer.
    Thu KL; Silvester J; Elliott MJ; Ba-Alawi W; Duncan MH; Elia AC; Mer AS; Smirnov P; Safikhani Z; Haibe-Kains B; Mak TW; Cescon DW
    Proc Natl Acad Sci U S A; 2018 Feb; 115(7):E1570-E1577. PubMed ID: 29378962
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs.
    Tannous BA; Kerami M; Van der Stoop PM; Kwiatkowski N; Wang J; Zhou W; Kessler AF; Lewandrowski G; Hiddingh L; Sol N; Lagerweij T; Wedekind L; Niers JM; Barazas M; Nilsson RJ; Geerts D; De Witt Hamer PC; Hagemann C; Vandertop WP; Van Tellingen O; Noske DP; Gray NS; Würdinger T
    J Natl Cancer Inst; 2013 Sep; 105(17):1322-31. PubMed ID: 23940287
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma.
    Szymiczek A; Carbone M; Pastorino S; Napolitano A; Tanji M; Minaai M; Pagano I; Mason JM; Pass HI; Bray MR; Mak TW; Yang H
    Oncogene; 2017 Nov; 36(46):6501-6507. PubMed ID: 28759042
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Hijacking monopolar spindle 1 (MPS1) for various cancer types by small molecular inhibitors: Deep insights from a decade of research and patents.
    Liang C; Zhou Y; Xin L; Kang K; Tian L; Zhang D; Li H; Zhao Q; Gao H; Shi Z
    Eur J Med Chem; 2024 Jul; 273():116504. PubMed ID: 38795520
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Expression and function analysis of mitotic checkpoint genes identifies TTK as a potential therapeutic target for human hepatocellular carcinoma.
    Liang XD; Dai YC; Li ZY; Gan MF; Zhang SR; Yin-Pan ; Lu HS; Cao XQ; Zheng BJ; Bao LF; Wang DD; Zhang LM; Ma SL
    PLoS One; 2014; 9(6):e97739. PubMed ID: 24905462
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors.
    Huang M; Huang Y; Guo J; Yu L; Chang Y; Wang X; Luo J; Huang Y; Tu Z; Lu X; Xu Y; Zhang Z; Zhang Z; Ding K
    Eur J Med Chem; 2021 Feb; 211():113023. PubMed ID: 33248853
    [TBL] [Abstract][Full Text] [Related]  

  • 32. MPS1 kinase as a potential therapeutic target in medulloblastoma.
    Alimova I; Ng J; Harris P; Birks D; Donson A; Taylor MD; Foreman NK; Venkataraman S; Vibhakar R
    Oncol Rep; 2016 Nov; 36(5):2633-2640. PubMed ID: 27633003
    [TBL] [Abstract][Full Text] [Related]  

  • 33. TTK inhibitor promotes radiosensitivity of liver cancer cells through p21.
    Zhang H; Yao W; Zhang M; Lu Y; Tang J; Jiang M; Mou X; You G; Liang X
    Biochem Biophys Res Commun; 2021 Apr; 550():84-91. PubMed ID: 33689884
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
    Uitdehaag JCM; de Man J; Willemsen-Seegers N; Prinsen MBW; Libouban MAA; Sterrenburg JG; de Wit JJP; de Vetter JRF; de Roos JADM; Buijsman RC; Zaman GJR
    J Mol Biol; 2017 Jul; 429(14):2211-2230. PubMed ID: 28539250
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer.
    Lim JS; Kim E; Song JS; Ahn S
    Oncol Rep; 2024 Aug; 52(2):. PubMed ID: 38904203
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.
    Laufer R; Ng G; Liu Y; Patel NK; Edwards LG; Lang Y; Li SW; Feher M; Awrey DE; Leung G; Beletskaya I; Plotnikova O; Mason JM; Hodgson R; Wei X; Mao G; Luo X; Huang P; Green E; Kiarash R; Lin DC; Harris-Brandts M; Ban F; Nadeem V; Mak TW; Pan GJ; Qiu W; Chirgadze NY; Pauls HW
    Bioorg Med Chem; 2014 Sep; 22(17):4968-97. PubMed ID: 25043312
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma.
    Simon Serrano S; Sime W; Abassi Y; Daams R; Massoumi R; Jemaà M
    Sci Rep; 2020 Jul; 10(1):11997. PubMed ID: 32686724
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III α-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis.
    Pradhan A; Singh TR; Ali AM; Wahengbam K; Meetei AR
    J Biol Chem; 2013 Nov; 288(47):33500-33508. PubMed ID: 24108125
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics.
    Zeng X; Xu WK; Lok TM; Ma HT; Poon RYC
    Cell Death Dis; 2019 Apr; 10(4):314. PubMed ID: 30952840
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
    Innocenti P; Woodward HL; Solanki S; Naud S; Westwood IM; Cronin N; Hayes A; Roberts J; Henley AT; Baker R; Faisal A; Mak GW; Box G; Valenti M; De Haven Brandon A; O'Fee L; Saville H; Schmitt J; Matijssen B; Burke R; van Montfort RL; Raynaud FI; Eccles SA; Linardopoulos S; Blagg J; Hoelder S
    J Med Chem; 2016 Apr; 59(8):3671-88. PubMed ID: 27055065
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 14.