169 related articles for article (PubMed ID: 28314512)
1. Modulation of opioid receptor affinity and efficacy via N-substitution of 9β-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study.
Truong PM; Hassan SA; Lee YS; Kopajtic TA; Katz JL; Chadderdon AM; Traynor JR; Deschamps JR; Jacobson AE; Rice KC
Bioorg Med Chem; 2017 Apr; 25(8):2406-2422. PubMed ID: 28314512
[TBL] [Abstract][Full Text] [Related]
2. Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series.
Hiebel AC; Lee YS; Bilsky E; Giuvelis D; Deschamps JR; Parrish DA; Aceto MD; May EL; Harris LS; Coop A; Dersch CM; Partilla JS; Rothman RB; Cheng K; Jacobson AE; Rice KC
J Med Chem; 2007 Aug; 50(16):3765-76. PubMed ID: 17625813
[TBL] [Abstract][Full Text] [Related]
3. Probes for narcotic receptor mediated phenomena. 44. Synthesis of an N-substituted 4-hydroxy-5-(3-hydroxyphenyl)morphan with high affinity and selective μ-antagonist activity.
Iyer MR; Lee YS; Deschamps JR; Dersch CM; Rothman RB; Jacobson AE; Rice KC
Eur J Med Chem; 2012 Apr; 50():44-54. PubMed ID: 22341895
[TBL] [Abstract][Full Text] [Related]
4. N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.
Thomas JB; Zheng X; Mascarella SW; Rothman RB; Dersch CM; Partilla JS; Flippen-Anderson JL; George CF; Cantrell BE; Zimmerman DM; Carroll FI
J Med Chem; 1998 Oct; 41(21):4143-9. PubMed ID: 9767649
[TBL] [Abstract][Full Text] [Related]
5. Probes for narcotic receptor mediated phenomena. Part 28: new opioid antagonists from enantiomeric analogues of 5-(3-hydroxyphenyl)-N-phenylethylmorphan.
Hashimoto A; Jacobson AE; Rothman RB; Dersch CM; George C; Flippen-Anderson JL; Rice KC
Bioorg Med Chem; 2002 Oct; 10(10):3319-29. PubMed ID: 12150879
[TBL] [Abstract][Full Text] [Related]
6. Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.
Bertha CM; Flippen-Anderson JL; Rothman RB; Porreca F; Davis P; Xu H; Becketts K; Cha XY; Rice KC
J Med Chem; 1995 Apr; 38(9):1523-37. PubMed ID: 7739011
[TBL] [Abstract][Full Text] [Related]
7. Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists.
Cheng K; Kim IJ; Lee MJ; Adah SA; Raymond TJ; Bilsky EJ; Aceto MD; May EL; Harris LS; Coop A; Dersch CM; Rothman RB; Jacobson AE; Rice KC
Org Biomol Chem; 2007 Apr; 5(8):1177-1190. PubMed ID: 17406716
[TBL] [Abstract][Full Text] [Related]
8. A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands.
Bertha CM; Mattson MV; Flippen-Anderson JL; Rothman RB; Xu H; Cha XY; Becketts K; Rice KC
J Med Chem; 1994 Sep; 37(19):3163-70. PubMed ID: 7932540
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues.
May EL; Jacobson AE; Mattson MV; Traynor JR; Woods JH; Harris LS; Bowman ER; Aceto MD
J Med Chem; 2000 Dec; 43(26):5030-6. PubMed ID: 11150174
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and pharmacological effects of the enantiomers of the N-phenethyl analogues of the ortho and para e- and f-oxide-bridged phenylmorphans.
Zezula J; Singer L; Przybył AK; Hashimoto A; Dersch CM; Rothman RB; Deschamps J; Lee YS; Jacobson AE; Rice KC
Org Biomol Chem; 2008 Aug; 6(16):2868-83. PubMed ID: 18688479
[TBL] [Abstract][Full Text] [Related]
11. Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [(35)S]GTP-gamma-S functional binding assay.
Xu H; Hashimoto A; Rice KC; Jacobson AE; Thomas JB; Carroll FI; Lai J; Rothman RB
Synapse; 2001 Jan; 39(1):64-9. PubMed ID: 11071711
[TBL] [Abstract][Full Text] [Related]
12. Probes for narcotic receptor mediated phenomena. 41. Unusual inverse μ-agonists and potent μ-opioid antagonists by modification of the N-substituent in enantiomeric 5-(3-hydroxyphenyl)morphans.
Cheng K; Lee YS; Rothman RB; Dersch CM; Bittman RW; Jacobson AE; Rice KC
J Med Chem; 2011 Feb; 54(4):957-69. PubMed ID: 21247164
[TBL] [Abstract][Full Text] [Related]
13. Differentiating aspects of opioid receptor binding by [3H](-) (1R,5R,9R,2''S)-5,9-dimethyl-2-tetrahydrofurfuryl-2'-hydroxy-6,7- benzomorphan hydrochloride ([3H]Mr 2034), a drug preferentially acting on kappa-receptors.
Ensinger HA
Arzneimittelforschung; 1985; 35(1A):447-51. PubMed ID: 2985096
[TBL] [Abstract][Full Text] [Related]
14. Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.
Ananthan S; Johnson CA; Carter RL; Clayton SD; Rice KC; Xu H; Davis P; Porreca F; Rothman RB
J Med Chem; 1998 Jul; 41(15):2872-81. PubMed ID: 9667975
[TBL] [Abstract][Full Text] [Related]
15. G-Protein biased opioid agonists: 3-hydroxy-
Gutman ES; Bow E; Li F; Sulima A; Kaska S; Crowley R; Prisinzano TE; Lee YS; Hassan SA; Imler GH; Deschamps JR; Jacobson AE; Rice KC
RSC Med Chem; 2020 Aug; 11(8):896-904. PubMed ID: 33479684
[TBL] [Abstract][Full Text] [Related]
16. Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans.
Lutz JA; Sulima A; Gutman ES; Bow EW; Luo D; Kaska S; Prisinzano TE; Paronis CA; Bergman J; Imler GH; Kerr AT; Jacobson AE; Rice KC
Molecules; 2023 Jun; 28(12):. PubMed ID: 37375350
[TBL] [Abstract][Full Text] [Related]
17. Functional Activity of Enantiomeric Oximes and Diastereomeric Amines and Cyano Substituents at C9 in 3-Hydroxy-
Roth HG; Das M; Sulima A; Luo D; Kaska S; Prisinzano TE; Kerr AT; Jacobson AE; Rice KC
Molecules; 2024 Apr; 29(9):. PubMed ID: 38731416
[TBL] [Abstract][Full Text] [Related]
18. Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.
McLamore S; Ullrich T; Rothman RB; Xu H; Dersch C; Coop A; Davis P; Porreca F; Jacobson AE; Rice KC
J Med Chem; 2001 Apr; 44(9):1471-4. PubMed ID: 11311071
[TBL] [Abstract][Full Text] [Related]
19. Absolute configuration and conformation of the pure opioid antagonist (+)-2,9 alpha-dimethyl-5-(m-hydroxyphenyl)morphan.
Froimowitz M; Pangborn W; Cody V
Chirality; 1992; 4(6):377-83. PubMed ID: 1449951
[TBL] [Abstract][Full Text] [Related]
20. Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors.
Zaveri NT; Journigan VB; Polgar WE
ACS Chem Neurosci; 2015 Apr; 6(4):646-57. PubMed ID: 25635572
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
