238 related articles for article (PubMed ID: 28315321)
21. The intricate interplay between HIFs, ROS, and the ubiquitin system in the tumor hypoxic microenvironment.
Wang Y; Liu X; Huang W; Liang J; Chen Y
Pharmacol Ther; 2022 Dec; 240():108303. PubMed ID: 36328089
[TBL] [Abstract][Full Text] [Related]
22. Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.
Turner KJ; Moore JW; Jones A; Taylor CF; Cuthbert-Heavens D; Han C; Leek RD; Gatter KC; Maxwell PH; Ratcliffe PJ; Cranston D; Harris AL
Cancer Res; 2002 May; 62(10):2957-61. PubMed ID: 12019178
[TBL] [Abstract][Full Text] [Related]
23. Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
Mole DR; Pugh CW; Ratcliffe PJ; Maxwell PH
Adv Enzyme Regul; 2002; 42():333-47. PubMed ID: 12123724
[No Abstract] [Full Text] [Related]
24. The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease.
Haase VH
Kidney Int; 2006 Apr; 69(8):1302-7. PubMed ID: 16531988
[TBL] [Abstract][Full Text] [Related]
25. Homotypic association between tumour-associated VHL proteins leads to the restoration of HIF pathway.
Chung J; Roberts AM; Chow J; Coady-Osberg N; Ohh M
Oncogene; 2006 May; 25(21):3079-83. PubMed ID: 16407835
[TBL] [Abstract][Full Text] [Related]
26. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
Blancher C; Moore JW; Robertson N; Harris AL
Cancer Res; 2001 Oct; 61(19):7349-55. PubMed ID: 11585776
[TBL] [Abstract][Full Text] [Related]
27. RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha.
van Hagen M; Overmeer RM; Abolvardi SS; Vertegaal AC
Nucleic Acids Res; 2010 Apr; 38(6):1922-31. PubMed ID: 20026589
[TBL] [Abstract][Full Text] [Related]
28. Molecular cloning and characterization of the von Hippel-Lindau-like protein.
Qi H; Gervais ML; Li W; DeCaprio JA; Challis JR; Ohh M
Mol Cancer Res; 2004 Jan; 2(1):43-52. PubMed ID: 14757845
[TBL] [Abstract][Full Text] [Related]
29. RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization.
Liu YV; Semenza GL
Cell Cycle; 2007 Mar; 6(6):656-9. PubMed ID: 17361105
[TBL] [Abstract][Full Text] [Related]
30. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
Marxsen JH; Stengel P; Doege K; Heikkinen P; Jokilehto T; Wagner T; Jelkmann W; Jaakkola P; Metzen E
Biochem J; 2004 Aug; 381(Pt 3):761-7. PubMed ID: 15104534
[TBL] [Abstract][Full Text] [Related]
31. Identification of novel VHL target genes and relationship to hypoxic response pathways.
Maina EN; Morris MR; Zatyka M; Raval RR; Banks RE; Richards FM; Johnson CM; Maher ER
Oncogene; 2005 Jun; 24(28):4549-58. PubMed ID: 15824735
[TBL] [Abstract][Full Text] [Related]
32. Activation of hypoxia-induced transcription in normoxia.
Hägg M; Wennström S
Exp Cell Res; 2005 May; 306(1):180-91. PubMed ID: 15878343
[TBL] [Abstract][Full Text] [Related]
33. The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.
Clifford SC; Astuti D; Hooper L; Maxwell PH; Ratcliffe PJ; Maher ER
Oncogene; 2001 Aug; 20(36):5067-74. PubMed ID: 11526493
[TBL] [Abstract][Full Text] [Related]
34. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction.
Buckley DL; Van Molle I; Gareiss PC; Tae HS; Michel J; Noblin DJ; Jorgensen WL; Ciulli A; Crews CM
J Am Chem Soc; 2012 Mar; 134(10):4465-8. PubMed ID: 22369643
[TBL] [Abstract][Full Text] [Related]
35. K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression.
Wu HT; Kuo YC; Hung JJ; Huang CH; Chen WY; Chou TY; Chen Y; Chen YJ; Chen YJ; Cheng WC; Teng SC; Wu KJ
Nat Commun; 2016 Dec; 7():13644. PubMed ID: 27934968
[TBL] [Abstract][Full Text] [Related]
36. Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
Hewitson KS; Schofield CJ; Ratcliffe PJ
Methods Enzymol; 2007; 435():25-42. PubMed ID: 17998047
[TBL] [Abstract][Full Text] [Related]
37. Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas.
Cuevas Y; Hernández-Alcoceba R; Aragones J; Naranjo-Suárez S; Castellanos MC; Esteban MA; Martín-Puig S; Landazuri MO; del Peso L
Cancer Res; 2003 Oct; 63(20):6877-84. PubMed ID: 14583486
[TBL] [Abstract][Full Text] [Related]
38. The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL.
Wang J; Pantopoulos K
Biochim Biophys Acta; 2005 Mar; 1743(1-2):79-85. PubMed ID: 15777842
[TBL] [Abstract][Full Text] [Related]
39. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Hon WC; Wilson MI; Harlos K; Claridge TD; Schofield CJ; Pugh CW; Maxwell PH; Ratcliffe PJ; Stuart DI; Jones EY
Nature; 2002 Jun; 417(6892):975-8. PubMed ID: 12050673
[TBL] [Abstract][Full Text] [Related]
40. Constitutive/hypoxic degradation of HIF-alpha proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein.
Kong X; Alvarez-Castelao B; Lin Z; Castaño JG; Caro J
J Biol Chem; 2007 May; 282(21):15498-505. PubMed ID: 17403672
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]