270 related articles for article (PubMed ID: 28330869)
1. Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.
Avellaneda Matteo D; Grunseth AJ; Gonzalez ER; Anselmo SL; Kennedy MA; Moman P; Scott DA; Hoang A; Sohl CD
J Biol Chem; 2017 May; 292(19):7971-7983. PubMed ID: 28330869
[TBL] [Abstract][Full Text] [Related]
2. Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants.
Avellaneda Matteo D; Wells GA; Luna LA; Grunseth AJ; Zagnitko O; Scott DA; Hoang A; Luthra A; Swairjo MA; Schiffer JM; Sohl CD
Biochem J; 2018 Oct; 475(20):3221-3238. PubMed ID: 30249606
[TBL] [Abstract][Full Text] [Related]
3. Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.
Chambers JM; Miller W; Quichocho G; Upadhye V; Matteo DA; Bobkov AA; Sohl CD; Schiffer JM
Biochemistry; 2020 Feb; 59(4):479-490. PubMed ID: 31869219
[TBL] [Abstract][Full Text] [Related]
4. Isocitrate dehydrogenase mutations in gliomas.
Waitkus MS; Diplas BH; Yan H
Neuro Oncol; 2016 Jan; 18(1):16-26. PubMed ID: 26188014
[TBL] [Abstract][Full Text] [Related]
5. Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics.
Weeks J; Strom AI; Widjaja V; Alexander S; Pucher DK; Sohl CD
Biomolecules; 2021 May; 11(5):. PubMed ID: 34065652
[TBL] [Abstract][Full Text] [Related]
6. An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.
Luna LA; Lesecq Z; White KA; Hoang A; Scott DA; Zagnitko O; Bobkov AA; Barber DL; Schiffer JM; Isom DG; Sohl CD
Biochem J; 2020 Aug; 477(16):2999-3018. PubMed ID: 32729927
[TBL] [Abstract][Full Text] [Related]
7. Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.
Rendina AR; Pietrak B; Smallwood A; Zhao H; Qi H; Quinn C; Adams ND; Concha N; Duraiswami C; Thrall SH; Sweitzer S; Schwartz B
Biochemistry; 2013 Jul; 52(26):4563-77. PubMed ID: 23731180
[TBL] [Abstract][Full Text] [Related]
8. Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.
van Lith SA; Navis AC; Lenting K; Verrijp K; Schepens JT; Hendriks WJ; Schubert NA; Venselaar H; Wevers RA; van Rooij A; Wesseling P; Molenaar RJ; van Noorden CJ; Pusch S; Tops B; Leenders WP
Sci Rep; 2016 Jul; 6():30486. PubMed ID: 27460417
[TBL] [Abstract][Full Text] [Related]
9. Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate.
Dexter JP; Ward PS; Dasgupta T; Hosios AM; Gunawardena J; Vander Heiden MG
J Biol Chem; 2018 Dec; 293(52):20051-20061. PubMed ID: 30381394
[TBL] [Abstract][Full Text] [Related]
10. IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis.
Gao Y; de Wit M; Struys EA; van der Linde HCZ; Salomons GS; Lamfers MLM; Willemsen R; Sillevis Smitt PAE; French PJ
PLoS One; 2018; 13(6):e0199737. PubMed ID: 29953513
[TBL] [Abstract][Full Text] [Related]
11. Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1
Waitkus MS; Pirozzi CJ; Moure CJ; Diplas BH; Hansen LJ; Carpenter AB; Yang R; Wang Z; Ingram BO; Karoly ED; Mohney RP; Spasojevic I; McLendon RE; Friedman HS; He Y; Bigner DD; Yan H
Cancer Res; 2018 Jan; 78(1):36-50. PubMed ID: 29097607
[TBL] [Abstract][Full Text] [Related]
12. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.
Gross S; Cairns RA; Minden MD; Driggers EM; Bittinger MA; Jang HG; Sasaki M; Jin S; Schenkein DP; Su SM; Dang L; Fantin VR; Mak TW
J Exp Med; 2010 Feb; 207(2):339-44. PubMed ID: 20142433
[TBL] [Abstract][Full Text] [Related]
13. A tale of two subunits: how the neomorphic R132H IDH1 mutation enhances production of αHG.
Pietrak B; Zhao H; Qi H; Quinn C; Gao E; Boyer JG; Concha N; Brown K; Duraiswami C; Wooster R; Sweitzer S; Schwartz B
Biochemistry; 2011 May; 50(21):4804-12. PubMed ID: 21524095
[TBL] [Abstract][Full Text] [Related]
14. Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation.
Leonardi R; Subramanian C; Jackowski S; Rock CO
J Biol Chem; 2012 Apr; 287(18):14615-20. PubMed ID: 22442146
[TBL] [Abstract][Full Text] [Related]
15. Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
Yang B; Zhong C; Peng Y; Lai Z; Ding J
Cell Res; 2010 Nov; 20(11):1188-200. PubMed ID: 20975740
[TBL] [Abstract][Full Text] [Related]
16. Isocitrate dehydrogenase mutation as a therapeutic target in gliomas.
Han CH; Batchelor TT
Chin Clin Oncol; 2017 Jun; 6(3):33. PubMed ID: 28705010
[TBL] [Abstract][Full Text] [Related]
17. Catalytically distinct IDH1 mutants tune phenotype severity in tumor models.
Adam MAA; Robinson M; Schwartz AV; Wells G; Hoang A; Albekioni E; Chao G; Weeks J; George UZ; House CD; Turcan Ş; Sohl CD
bioRxiv; 2024 Apr; ():. PubMed ID: 38712107
[TBL] [Abstract][Full Text] [Related]
18. Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities.
Cairns RA; Mak TW
Cancer Discov; 2013 Jul; 3(7):730-41. PubMed ID: 23796461
[TBL] [Abstract][Full Text] [Related]
19. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.
Badur MG; Muthusamy T; Parker SJ; Ma S; McBrayer SK; Cordes T; Magana JH; Guan KL; Metallo CM
Cell Rep; 2018 Oct; 25(4):1018-1026.e4. PubMed ID: 30355481
[TBL] [Abstract][Full Text] [Related]
20. Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation.
Ohka F; Ito M; Ranjit M; Senga T; Motomura A; Motomura K; Saito K; Kato K; Kato Y; Wakabayashi T; Soga T; Natsume A
Tumour Biol; 2014 Jun; 35(6):5911-20. PubMed ID: 24590270
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]