BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

338 related articles for article (PubMed ID: 28344327)

  • 1. Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.
    Alizadeh J; Zeki AA; Mirzaei N; Tewary S; Rezaei Moghadam A; Glogowska A; Nagakannan P; Eftekharpour E; Wiechec E; Gordon JW; Xu FY; Field JT; Yoneda KY; Kenyon NJ; Hashemi M; Hatch GM; Hombach-Klonisch S; Klonisch T; Ghavami S
    Sci Rep; 2017 Mar; 7():44841. PubMed ID: 28344327
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.
    Zhu Y; Casey PJ; Kumar AP; Pervaiz S
    Cell Death Dis; 2013 Apr; 4(4):e568. PubMed ID: 23559002
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin.
    Takeda N; Kondo M; Ito S; Ito Y; Shimokata K; Kume H
    Am J Respir Cell Mol Biol; 2006 Dec; 35(6):722-9. PubMed ID: 16858009
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts.
    Schaafsma D; McNeill KD; Mutawe MM; Ghavami S; Unruh H; Jacques E; Laviolette M; Chakir J; Halayko AJ
    Respir Res; 2011 Aug; 12(1):113. PubMed ID: 21864337
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition.
    Tanaka T; Tatsuno I; Uchida D; Moroo I; Morio H; Nakamura S; Noguchi Y; Yasuda T; Kitagawa M; Saito Y; Hirai A
    J Neurosci; 2000 Apr; 20(8):2852-9. PubMed ID: 10751437
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle.
    Schaafsma D; Dueck G; Ghavami S; Kroeker A; Mutawe MM; Hauff K; Xu FY; McNeill KD; Unruh H; Hatch GM; Halayko AJ
    Am J Respir Cell Mol Biol; 2011 Mar; 44(3):394-403. PubMed ID: 20463291
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes.
    Massonnet B; Normand S; Moschitz R; Delwail A; Favot L; Garcia M; Bourmeyster N; Cuisset L; Grateau G; Morel F; Silvain C; Lecron JC
    Eur Cytokine Netw; 2009 Sep; 20(3):112-20. PubMed ID: 19825520
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.
    Kusama T; Mukai M; Tatsuta M; Nakamura H; Inoue M
    Int J Oncol; 2006 Jul; 29(1):217-23. PubMed ID: 16773203
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins).
    Eberlein M; Heusinger-Ribeiro J; Goppelt-Struebe M
    Br J Pharmacol; 2001 Aug; 133(7):1172-80. PubMed ID: 11487529
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells.
    Gbelcová H; Rimpelová S; Knejzlík Z; Šáchová J; Kolář M; Strnad H; Repiská V; D'Acunto WC; Ruml T; Vítek L
    Lipids Health Dis; 2017 Dec; 16(1):250. PubMed ID: 29262834
    [TBL] [Abstract][Full Text] [Related]  

  • 11. HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway.
    Fuchs D; Berges C; Opelz G; Daniel V; Naujokat C
    Biochem Biophys Res Commun; 2008 Sep; 374(2):309-14. PubMed ID: 18625202
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effect of simvastatin on cell proliferation and Ras activation in canine tumour cells.
    Kobayashi K; Baba K; Kambayashi S; Okuda M
    Vet Comp Oncol; 2021 Mar; 19(1):99-108. PubMed ID: 32779819
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension.
    Liu WH; Xu XH; Luo Q; Zhang HL; Wang Y; Xi QY; Zhao ZH; Liu ZH
    Clin Exp Hypertens; 2018; 40(3):224-230. PubMed ID: 29319354
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.
    Lee MH; Cho YS; Han YM
    Stem Cells; 2007 Jul; 25(7):1654-63. PubMed ID: 17464088
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Simvastatin Reduces Cancerogenic Potential of Renal Cancer Cells via Geranylgeranyl Pyrophosphate and Mevalonate Pathway.
    Woschek M; Kneip N; Jurida K; Marzi I; Relja B
    Nutr Cancer; 2016; 68(3):420-7. PubMed ID: 27042994
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway.
    Gopalan A; Yu W; Sanders BG; Kline K
    Cancer Lett; 2013 Feb; 329(1):9-16. PubMed ID: 22960596
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
    Maeda T; Horiuchi N
    J Biochem; 2009 Jun; 145(6):771-81. PubMed ID: 19254925
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins.
    Ghavami S; Sharma P; Yeganeh B; Ojo OO; Jha A; Mutawe MM; Kashani HH; Los MJ; Klonisch T; Unruh H; Halayko AJ
    Biochim Biophys Acta; 2014 Jul; 1843(7):1259-71. PubMed ID: 24637330
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Protein prenylation contributes to the effects of LPS on EFS-induced responses in human isolated bronchi.
    Cazzola M; Calzetta L; Page CP; Rinaldi B; Capuano A; Matera MG
    Am J Respir Cell Mol Biol; 2011 Oct; 45(4):704-10. PubMed ID: 21278325
    [TBL] [Abstract][Full Text] [Related]  

  • 20. HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation.
    Al-Haidari AA; Syk I; Thorlacius H
    Biochem Biophys Res Commun; 2014 Mar; 446(1):68-72. PubMed ID: 24582560
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.