BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

282 related articles for article (PubMed ID: 28349921)

  • 1. Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability.
    Julian MC; Li L; Garde S; Wilen R; Tessier PM
    Sci Rep; 2017 Mar; 7():45259. PubMed ID: 28349921
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs.
    Tiller KE; Li L; Kumar S; Julian MC; Garde S; Tessier PM
    J Biol Chem; 2017 Oct; 292(40):16638-16652. PubMed ID: 28778924
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies.
    Julian MC; Lee CC; Tiller KE; Rabia LA; Day EK; Schick AJ; Tessier PM
    Protein Eng Des Sel; 2015 Oct; 28(10):339-50. PubMed ID: 26386257
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions.
    Perchiacca JM; Ladiwala AR; Bhattacharya M; Tessier PM
    Protein Eng Des Sel; 2012 Oct; 25(10):591-601. PubMed ID: 22843678
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation.
    Wang F; Sen S; Zhang Y; Ahmad I; Zhu X; Wilson IA; Smider VV; Magliery TJ; Schultz PG
    Proc Natl Acad Sci U S A; 2013 Mar; 110(11):4261-6. PubMed ID: 23440204
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis.
    Tiller KE; Chowdhury R; Li T; Ludwig SD; Sen S; Maranas CD; Tessier PM
    Front Immunol; 2017; 8():986. PubMed ID: 28928732
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide.
    Lee CC; Julian MC; Tiller KE; Meng F; DuConge SE; Akter R; Raleigh DP; Tessier PM
    J Biol Chem; 2016 Feb; 291(6):2858-73. PubMed ID: 26601942
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Development of an affinity-matured humanized anti-epidermal growth factor receptor antibody for cancer immunotherapy.
    Nakanishi T; Maru T; Tahara K; Sanada H; Umetsu M; Asano R; Kumagai I
    Protein Eng Des Sel; 2013 Feb; 26(2):113-22. PubMed ID: 23118340
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Chemical basis for the affinity maturation of a camel single domain antibody.
    De Genst E; Handelberg F; Van Meirhaeghe A; Vynck S; Loris R; Wyns L; Muyldermans S
    J Biol Chem; 2004 Dec; 279(51):53593-601. PubMed ID: 15383540
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold.
    Perchiacca JM; Lee CC; Tessier PM
    Protein Eng Des Sel; 2014 Feb; 27(2):29-39. PubMed ID: 24398633
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
    Tu C; Terraube V; Tam AS; Stochaj W; Fennell BJ; Lin L; Stahl M; LaVallie ER; Somers W; Finlay WJ; Mosyak L; Bard J; Cunningham O
    J Biol Chem; 2016 Jan; 291(3):1267-76. PubMed ID: 26515064
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR.
    Simons JF; Lim YW; Carter KP; Wagner EK; Wayham N; Adler AS; Johnson DS
    MAbs; 2020; 12(1):1803646. PubMed ID: 32744131
    [TBL] [Abstract][Full Text] [Related]  

  • 13. An integrated approach to extreme thermostabilization and affinity maturation of an antibody.
    McConnell AD; Spasojevich V; Macomber JL; Krapf IP; Chen A; Sheffer JC; Berkebile A; Horlick RA; Neben S; King DJ; Bowers PM
    Protein Eng Des Sel; 2013 Feb; 26(2):151-64. PubMed ID: 23173178
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antibody Affinity and Stability Maturation by Error-Prone PCR.
    Unkauf T; Hust M; Frenzel A
    Methods Mol Biol; 2018; 1701():393-407. PubMed ID: 29116518
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Thermodynamic consequences of mutations in vernier zone residues of a humanized anti-human epidermal growth factor receptor murine antibody, 528.
    Makabe K; Nakanishi T; Tsumoto K; Tanaka Y; Kondo H; Umetsu M; Sone Y; Asano R; Kumagai I
    J Biol Chem; 2008 Jan; 283(2):1156-66. PubMed ID: 17947238
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The Antibody Light-Chain Linker Is Important for Domain Stability and Amyloid Formation.
    Nokwe CN; Hora M; Zacharias M; Yagi H; John C; Reif B; Goto Y; Buchner J
    J Mol Biol; 2015 Nov; 427(22):3572-3586. PubMed ID: 26408269
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.
    Rothe C; Urlinger S; Löhning C; Prassler J; Stark Y; Jäger U; Hubner B; Bardroff M; Pradel I; Boss M; Bittlingmaier R; Bataa T; Frisch C; Brocks B; Honegger A; Urban M
    J Mol Biol; 2008 Feb; 376(4):1182-200. PubMed ID: 18191144
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
    Chan DTY; Jenkinson L; Haynes SW; Austin M; Diamandakis A; Burschowsky D; Seewooruthun C; Addyman A; Fiedler S; Ryman S; Whitehouse J; Slater LH; Gowans E; Shibata Y; Barnard M; Wilkinson RW; Vaughan TJ; Holt SV; Cerundolo V; Carr MD; Groves MAT
    Proc Natl Acad Sci U S A; 2020 Jul; 117(29):16949-16960. PubMed ID: 32616569
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments.
    Chang HJ; Jian JW; Hsu HJ; Lee YC; Chen HS; You JJ; Hou SC; Shao CY; Chen YJ; Chiu KP; Peng HP; Lee KH; Yang AS
    Structure; 2014 Jan; 22(1):9-21. PubMed ID: 24268648
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Affinity maturation of a humanized rat antibody for anti-RAGE therapy: comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions.
    Finlay WJ; Cunningham O; Lambert MA; Darmanin-Sheehan A; Liu X; Fennell BJ; Mahon CM; Cummins E; Wade JM; O'Sullivan CM; Tan XY; Piche N; Pittman DD; Paulsen J; Tchistiakova L; Kodangattil S; Gill D; Hufton SE
    J Mol Biol; 2009 May; 388(3):541-58. PubMed ID: 19285987
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.