BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

384 related articles for article (PubMed ID: 28351590)

  • 1. Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors.
    Dong G; Fang Y; Liu Y; Liu N; Wu S; Zhang W; Sheng C
    Bioorg Med Chem Lett; 2017 May; 27(9):1929-1933. PubMed ID: 28351590
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors.
    Zhang C; Li S; Ji L; Liu S; Li Z; Li S; Meng X
    Bioorg Med Chem Lett; 2015 Oct; 25(20):4693-6. PubMed ID: 26384290
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents.
    Lee YR; Chen TC; Lee CC; Chen CL; Ahmed Ali AA; Tikhomirov A; Guh JH; Yu DS; Huang HS
    Eur J Med Chem; 2015 Sep; 102():661-76. PubMed ID: 26344783
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and biological evaluations of novel indenoisoquinolines as topoisomerase I inhibitors.
    Zhang X; Wang R; Zhao L; Lu N; Wang J; You Q; Li Z; Guo Q
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1276-81. PubMed ID: 22079759
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity.
    Majumdar P; Bathula C; Basu SM; Das SK; Agarwal R; Hati S; Singh A; Sen S; Das BB
    Eur J Med Chem; 2015 Sep; 102():540-51. PubMed ID: 26312433
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis and biological evaluation of lapachol derivatives possessing indole scaffolds as topoisomerase I inhibitors.
    Zhang C; Qu Y; Niu B
    Bioorg Med Chem; 2016 Nov; 24(22):5781-5786. PubMed ID: 27667553
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor.
    Park S; Thapa Magar TB; Kadayat TM; Lee HJ; Bist G; Shrestha A; Lee ES; Kwon Y
    Eur J Med Chem; 2017 Feb; 127():318-333. PubMed ID: 28068603
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors.
    Yu LM; Zhang XR; Li XB; Yang Y; Wei HY; He XX; Gu LQ; Huang ZS; Pommier Y; An LK
    Eur J Med Chem; 2015 Aug; 101():525-33. PubMed ID: 26188908
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis, Molecular Docking and Biological Evaluation of Quinolone Derivatives as Novel Anticancer Agents.
    Li J; Zheng TC; Jin Y; Xu JG; Yu JG; Lv YW
    Chem Pharm Bull (Tokyo); 2018 Jan; 66(1):55-60. PubMed ID: 29118308
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors.
    Yu Q; Yang H; Zhu TW; Yu LM; Chen JW; Gu LQ; Huang ZS; An LK
    Eur J Med Chem; 2018 May; 152():195-207. PubMed ID: 29705710
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis and biological evaluation of new β-carboline-bisindole compounds as DNA binding, photocleavage agents and topoisomerase I inhibitors.
    Kovvuri J; Nagaraju B; Nayak VL; Akunuri R; Rao MPN; Ajitha A; Nagesh N; Kamal A
    Eur J Med Chem; 2018 Jan; 143():1563-1577. PubMed ID: 29129513
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors.
    Cheng P; Zhu L; Guo W; Liu W; Yao J; Dong G; Zhang Y; Zhuang C; Sheng C; Miao Z; Zhang W
    J Enzyme Inhib Med Chem; 2012 Jun; 27(3):437-42. PubMed ID: 21770860
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors.
    Liu W; Zhu L; Guo W; Zhuang C; Zhang Y; Sheng C; Cheng P; Yao J; Wang W; Dong G; Wang S; Miao Z; Zhang W
    Eur J Med Chem; 2011 Jun; 46(6):2408-14. PubMed ID: 21463912
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and biological evaluation of novel homocamptothecins conjugating with dihydropyrimidine derivatives as potent topoisomerase I inhibitors.
    Zhu L; Cheng P; Lei N; Yao J; Sheng C; Zhuang C; Guo W; Liu W; Zhang Y; Dong G; Wang S; Miao Z; Zhang W
    Arch Pharm (Weinheim); 2011 Nov; 344(11):726-34. PubMed ID: 21956522
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors.
    My Van HT; Woo H; Jeong HM; Khadka DB; Yang SH; Zhao C; Jin Y; Lee ES; Youl Lee K; Kwon Y; Cho WJ
    Eur J Med Chem; 2014 Jul; 82():181-94. PubMed ID: 24904965
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis of 9-(heteroarylmethylidene)amino derivatives of homocamptothecin with biological activities.
    Guo W; Miao Z; Sheng C; Yao J; Liu W; Zhu L; Zhang Y; Cheng P; Dong G; Zhuang C; Zhang W
    Chem Biodivers; 2011 Jul; 8(7):1266-73. PubMed ID: 21766447
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular modelling design, synthesis and cytotoxic evaluation of certain substituted 2-(3,4,5-triacetoxybenzoylamino)benzo[d]thiazole and 2-(galloylamino)benzo[d]thiazole derivatives having potential topoisomerase-I inhibitory activity.
    Ismail MA; Tratrat C; Haroun MG
    J Enzyme Inhib Med Chem; 2013 Dec; 28(6):1331-45. PubMed ID: 22957723
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis and biological evaluation of 3-substituted indenoisoquinoline derivatives as topoisomerase I inhibitors.
    Zhao Q; Xu X; Xie Z; Liu X; You Q; Guo Q; Zhong Y; Li Z
    Bioorg Med Chem Lett; 2016 Feb; 26(3):1068-1072. PubMed ID: 26725027
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel 4-(4-substituted amidobenzyl)furan-2(5H)-one derivatives as topoisomerase I inhibitors.
    Peng CK; Zeng T; Xu XJ; Chang YQ; Hou W; Lu K; Lin H; Sun PH; Lin J; Chen WM
    Eur J Med Chem; 2017 Feb; 127():187-199. PubMed ID: 28063351
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and Topoisomerase I inhibitory properties of klavuzon derivatives.
    Akçok İ; Mete D; Şen A; Kasaplar P; Korkmaz KS; Çağır A
    Bioorg Chem; 2017 Apr; 71():275-284. PubMed ID: 28242062
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.