240 related articles for article (PubMed ID: 28369545)
1. Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites.
Deshpande RA; Lee JH; Paull TT
Nucleic Acids Res; 2017 May; 45(9):5255-5268. PubMed ID: 28369545
[TBL] [Abstract][Full Text] [Related]
2. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
Lee JH; Mand MR; Deshpande RA; Kinoshita E; Yang SH; Wyman C; Paull TT
J Biol Chem; 2013 May; 288(18):12840-51. PubMed ID: 23525106
[TBL] [Abstract][Full Text] [Related]
3. ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.
Hopfner KP
Bioessays; 2014 Dec; 36(12):1170-8. PubMed ID: 25213441
[TBL] [Abstract][Full Text] [Related]
4. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
Deshpande RA; Williams GJ; Limbo O; Williams RS; Kuhnlein J; Lee JH; Classen S; Guenther G; Russell P; Tainer JA; Paull TT
EMBO J; 2014 Mar; 33(5):482-500. PubMed ID: 24493214
[TBL] [Abstract][Full Text] [Related]
5. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
Williams RS; Williams JS; Tainer JA
Biochem Cell Biol; 2007 Aug; 85(4):509-20. PubMed ID: 17713585
[TBL] [Abstract][Full Text] [Related]
6. A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair.
Boswell ZK; Rahman S; Canny MD; Latham MP
Sci Rep; 2018 Jan; 8(1):1639. PubMed ID: 29374232
[TBL] [Abstract][Full Text] [Related]
7. The ATP-bound conformation of the Mre11-Rad50 complex is essential for Tel1/ATM activation.
Cassani C; Vertemara J; Bassani M; Marsella A; Tisi R; Zampella G; Longhese MP
Nucleic Acids Res; 2019 Apr; 47(7):3550-3567. PubMed ID: 30698745
[TBL] [Abstract][Full Text] [Related]
8. The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.
Lammens K; Bemeleit DJ; Möckel C; Clausing E; Schele A; Hartung S; Schiller CB; Lucas M; Angermüller C; Söding J; Strässer K; Hopfner KP
Cell; 2011 Apr; 145(1):54-66. PubMed ID: 21458667
[TBL] [Abstract][Full Text] [Related]
9. Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.
Rojowska A; Lammens K; Seifert FU; Direnberger C; Feldmann H; Hopfner KP
EMBO J; 2014 Dec; 33(23):2847-59. PubMed ID: 25349191
[TBL] [Abstract][Full Text] [Related]
10. Human RAD50 makes a functional DNA-binding complex.
Kinoshita E; van Rossum-Fikkert S; Sanchez H; Kertokalio A; Wyman C
Biochimie; 2015 Jun; 113():47-53. PubMed ID: 25828805
[TBL] [Abstract][Full Text] [Related]
11. Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET.
Cannon B; Kuhnlein J; Yang SH; Cheng A; Schindler D; Stark JM; Russell R; Paull TT
Proc Natl Acad Sci U S A; 2013 Nov; 110(47):18868-73. PubMed ID: 24191051
[TBL] [Abstract][Full Text] [Related]
12. The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity.
Ghosal G; Muniyappa K
J Mol Biol; 2007 Sep; 372(4):864-882. PubMed ID: 17698079
[TBL] [Abstract][Full Text] [Related]
13. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
Lee JH; Paull TT
Science; 2005 Apr; 308(5721):551-4. PubMed ID: 15790808
[TBL] [Abstract][Full Text] [Related]
14. NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein.
Zhou H; Kawamura K; Yanagihara H; Kobayashi J; Zhang-Akiyama QM
J Radiat Res; 2017 Jul; 58(4):487-494. PubMed ID: 28369484
[TBL] [Abstract][Full Text] [Related]
15. Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts.
Deshpande RA; Lee JH; Arora S; Paull TT
Mol Cell; 2016 Nov; 64(3):593-606. PubMed ID: 27814491
[TBL] [Abstract][Full Text] [Related]
16. Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.
Henrich SM; Usadel C; Werwein E; Burdova K; Janscak P; Ferrari S; Hess D; Klempnauer KH
Sci Rep; 2017 Jan; 7():41663. PubMed ID: 28128338
[TBL] [Abstract][Full Text] [Related]
17. Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Rotheneder M; Stakyte K; van de Logt E; Bartho JD; Lammens K; Fan Y; Alt A; Kessler B; Jung C; Roos WP; Steigenberger B; Hopfner KP
Mol Cell; 2023 Jan; 83(2):167-185.e9. PubMed ID: 36577401
[TBL] [Abstract][Full Text] [Related]
18. Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
Bhaskara V; Dupré A; Lengsfeld B; Hopkins BB; Chan A; Lee JH; Zhang X; Gautier J; Zakian V; Paull TT
Mol Cell; 2007 Mar; 25(5):647-61. PubMed ID: 17349953
[TBL] [Abstract][Full Text] [Related]
19. Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in
Li Y; Wang J; Zhou G; Lajeunesse M; Le N; Stawicki BN; Corcino YL; Berkner KL; Runge KW
Genetics; 2017 May; 206(1):481-496. PubMed ID: 28292918
[TBL] [Abstract][Full Text] [Related]
20. Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Gut F; Käshammer L; Lammens K; Bartho JD; Boggusch AM; van de Logt E; Kessler B; Hopfner KP
Mol Cell; 2022 Sep; 82(18):3513-3522.e6. PubMed ID: 35987200
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
