BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

173 related articles for article (PubMed ID: 28377716)

  • 1. Human Cytochrome P450 3A4 as a Biocatalyst: Effects of the Engineered Linker in Modulation of Coupling Efficiency in 3A4-BMR Chimeras.
    Degregorio D; D'Avino S; Castrignanò S; Di Nardo G; Sadeghi SJ; Catucci G; Gilardi G
    Front Pharmacol; 2017; 8():121. PubMed ID: 28377716
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modulation of the interaction between human P450 3A4 and B. megaterium reductase via engineered loops.
    Castrignanò S; D'Avino S; Di Nardo G; Catucci G; Sadeghi SJ; Gilardi G
    Biochim Biophys Acta Proteins Proteom; 2018 Jan; 1866(1):116-125. PubMed ID: 28734977
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Influence of inter-domain dynamics and surrounding environment flexibility on the direct electrochemistry and electrocatalysis of self-sufficient cytochrome P450 3A4-BMR chimeras.
    Castrignanò S; Di Nardo G; Sadeghi SJ; Gilardi G
    J Inorg Biochem; 2018 Nov; 188():9-17. PubMed ID: 30098472
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular Lego of Human Cytochrome P450: The Key Role of Heme Domain Flexibility for the Activity of the Chimeric Proteins.
    Catucci G; Ciaramella A; Di Nardo G; Zhang C; Castrignanò S; Gilardi G
    Int J Mol Sci; 2022 Mar; 23(7):. PubMed ID: 35408976
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The Flavin-Containing Reductase Domain of Cytochrome P450 BM3 Acts as a Surrogate for Mammalian NADPH-P450 Reductase.
    Park SH; Kang JY; Kim DH; Ahn T; Yun CH
    Biomol Ther (Seoul); 2012 Nov; 20(6):562-8. PubMed ID: 24009851
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Understanding uncoupling in the multiredox centre P450 3A4-BMR model system.
    Degregorio D; Sadeghi SJ; Di Nardo G; Gilardi G; Solinas SP
    J Biol Inorg Chem; 2011 Jan; 16(1):109-16. PubMed ID: 20857167
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Coexpression of genetically engineered fused enzyme between yeast NADPH-P450 reductase and human cytochrome P450 3A4 and human cytochrome b5 in yeast.
    Hayashi K; Sakaki T; Kominami S; Inouye K; Yabusaki Y
    Arch Biochem Biophys; 2000 Sep; 381(1):164-70. PubMed ID: 11019832
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The effects of cytochrome b5, NADPH-P450 reductase, and lipid on the rate of 6 beta-hydroxylation of testosterone as catalyzed by a human P450 3A4 fusion protein.
    Shet MS; Faulkner KM; Holmans PL; Fisher CW; Estabrook RW
    Arch Biochem Biophys; 1995 Apr; 318(2):314-21. PubMed ID: 7733659
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.
    Yamazaki H; Johnson WW; Ueng YF; Shimada T; Guengerich FP
    J Biol Chem; 1996 Nov; 271(44):27438-44. PubMed ID: 8910324
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5.
    Shaw PM; Hosea NA; Thompson DV; Lenius JM; Guengerich FP
    Arch Biochem Biophys; 1997 Dec; 348(1):107-15. PubMed ID: 9390180
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Engineering human cytochrome P450 enzymes into catalytically self-sufficient chimeras using molecular Lego.
    Dodhia VR; Fantuzzi A; Gilardi G
    J Biol Inorg Chem; 2006 Oct; 11(7):903-16. PubMed ID: 16862439
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Equilibrium and transient state spectrophotometric studies of the mechanism of reduction of the flavoprotein domain of P450BM-3.
    Sevrioukova I; Shaffer C; Ballou DP; Peterson JA
    Biochemistry; 1996 Jun; 35(22):7058-68. PubMed ID: 8679531
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein.
    Lin HL; Kent UM; Hollenberg PF
    J Pharmacol Exp Ther; 2002 Apr; 301(1):160-7. PubMed ID: 11907170
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Approaches for increasing the electrocatalitic efficiency of cytochrome P450 3A4.
    Shumyantseva VV; Koroleva PI; Bulko TV; Shkel TV; Gilep AA; Veselovsky AV
    Bioelectrochemistry; 2023 Feb; 149():108277. PubMed ID: 36198256
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes.
    Yamazaki H; Nakano M; Imai Y; Ueng YF; Guengerich FP; Shimada T
    Arch Biochem Biophys; 1996 Jan; 325(2):174-82. PubMed ID: 8561495
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Functional characterisation of an engineered multidomain human P450 2E1 by molecular Lego.
    Fairhead M; Giannini S; Gillam EM; Gilardi G
    J Biol Inorg Chem; 2005 Dec; 10(8):842-53. PubMed ID: 16283395
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Chimeric cytochrome P450 3A4 used for in vitro prediction of food-drug interactions.
    Sadeghi SJ; Di Nardo G; Gilardi G
    Biotechnol Appl Biochem; 2020 Jul; 67(4):541-548. PubMed ID: 32713008
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Electron transfer properties and catalytic competence of cytochrome b5 in the fusion protein Hmwb5-EGFP in reactions catalyzed by cytochrome P450 3A4.
    Yantsevich AV; Gilep AA; Usanov SA
    Biochemistry (Mosc); 2009 Aug; 74(8):862-73. PubMed ID: 19817686
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cryo-EM reveals the architecture of the dimeric cytochrome P450 CYP102A1 enzyme and conformational changes required for redox partner recognition.
    Su M; Chakraborty S; Osawa Y; Zhang H
    J Biol Chem; 2020 Feb; 295(6):1637-1645. PubMed ID: 31901079
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer.
    Girvan HM; Dunford AJ; Neeli R; Ekanem IS; Waltham TN; Joyce MG; Leys D; Curtis RA; Williams P; Fisher K; Voice MW; Munro AW
    Arch Biochem Biophys; 2011 Mar; 507(1):75-85. PubMed ID: 20868649
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.