98 related articles for article (PubMed ID: 28408226)
1. Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors.
Sakurada I; Endo T; Hikita K; Hirabayashi T; Hosaka Y; Kato Y; Maeda Y; Matsumoto S; Mizuno T; Nagasue H; Nishimura T; Shimada S; Shinozaki M; Taguchi K; Takeuchi K; Yokoyama T; Hruza A; Reichert P; Zhang T; Wood HB; Nakao K; Furusako S
Bioorg Med Chem Lett; 2017 Jun; 27(11):2622-2628. PubMed ID: 28408226
[TBL] [Abstract][Full Text] [Related]
2. Development of a novel class of potent and selective FIXa inhibitors.
Zhang T; Andre P; Bateman TJ; Chen YH; Desai K; Ellsworth K; Geissler WM; Guo L; Hruza A; Jian T; Meng D; Parker DL; Qian X; Reichert P; Sherer EC; Shu M; Smith CJ; Sonatore LM; Tschirret-Guth R; Nolting AF; Orr R; Campeau LC; Araki K; Nishimura T; Sakurada I; Wood HB
Bioorg Med Chem Lett; 2015 Nov; 25(21):4945-4949. PubMed ID: 25978966
[TBL] [Abstract][Full Text] [Related]
3. Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Meng D; Andre P; Bateman TJ; Berger R; Chen YH; Desai K; Dewnani S; Ellsworth K; Feng D; Geissler WM; Guo L; Hruza A; Jian T; Li H; Metzger J; Parker DL; Reichert P; Sherer EC; Smith CJ; Sonatore LM; Tschirret-Guth R; Wu J; Xu J; Zhang T; Campeau LC; Orr R; Poirier M; McCabe-Dunn J; Araki K; Nishimura T; Sakurada I; Hirabayashi T; Wood HB
Bioorg Med Chem Lett; 2015 Nov; 25(22):5437-43. PubMed ID: 26318999
[TBL] [Abstract][Full Text] [Related]
4. A Structure Based Study of Selective Inhibition of Factor IXa over Factor Xa.
Kundu S; Wu S
Molecules; 2021 Sep; 26(17):. PubMed ID: 34500804
[TBL] [Abstract][Full Text] [Related]
5. Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors.
Wang S; Beck R; Burd A; Blench T; Marlin F; Ayele T; Buxton S; Dagostin C; Malic M; Joshi R; Barry J; Sajad M; Cheung C; Shaikh S; Chahwala S; Chander C; Baumgartner C; Holthoff HP; Murray E; Blackney M; Giddings A
J Med Chem; 2010 Feb; 53(4):1473-82. PubMed ID: 20121197
[TBL] [Abstract][Full Text] [Related]
6. Sodium-site in serine protease domain of human coagulation factor IXa: evidence from the crystal structure and molecular dynamics simulations study.
Vadivel K; Schreuder HA; Liesum A; Schmidt AE; Goldsmith G; Bajaj SP
J Thromb Haemost; 2019 Apr; 17(4):574-584. PubMed ID: 30725510
[TBL] [Abstract][Full Text] [Related]
7. Heparinless cardiopulmonary bypass with active-site blocked factor IXa: a preliminary study on the dog.
Spanier TB; Oz MC; Minanov OP; Simantov R; Kisiel W; Stern DM; Rose EA; Schmidt AM
J Thorac Cardiovasc Surg; 1998 May; 115(5):1179-88. PubMed ID: 9605089
[TBL] [Abstract][Full Text] [Related]
8. Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.
Wang S; Beck R; Blench T; Burd A; Buxton S; Malic M; Ayele T; Shaikh S; Chahwala S; Chander C; Holland R; Merette S; Zhao L; Blackney M; Watts A
J Med Chem; 2010 Feb; 53(4):1465-72. PubMed ID: 20121198
[TBL] [Abstract][Full Text] [Related]
9. Anti-factor IXa Aptamer reduces propagation of thrombin generation in plasma anticoagulated with warfarin.
Szlam F; Luan D; Bolliger D; Szlam AD; Levy JH; Varner JD; Tanaka KA
Thromb Res; 2010 May; 125(5):432-7. PubMed ID: 20004955
[TBL] [Abstract][Full Text] [Related]
10. In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry.
Tanaka KA; Szlam F; Rusconi CP; Levy JH
Thromb Haemost; 2009 May; 101(5):827-33. PubMed ID: 19404534
[TBL] [Abstract][Full Text] [Related]
11. Investigation on the binding mode of benzothiophene analogues as potent factor IXa (FIXa) inhibitors in thrombosis by CoMFA, docking and molecular dynamic studies.
Hao M; Li Y; Zhang SW; Yang W
J Enzyme Inhib Med Chem; 2011 Dec; 26(6):792-804. PubMed ID: 21381886
[TBL] [Abstract][Full Text] [Related]
12. SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa.
Smallheer JM; Alexander RS; Wang J; Wang S; Nakajima S; Rossi KA; Smallwood A; Barbera F; Burdick D; Luettgen JM; Knabb RM; Wexler RR; Jadhav PK
Bioorg Med Chem Lett; 2004 Nov; 14(21):5263-7. PubMed ID: 15454208
[TBL] [Abstract][Full Text] [Related]
13. Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.
Zhang T; Liu Y; Yang X; Martin GE; Yao H; Shang J; Bugianesi RM; Ellsworth KP; Sonatore LM; Nizner P; Sherer EC; Hill SE; Knemeyer IW; Geissler WM; Dandliker PJ; Helmy R; Wood HB
J Med Chem; 2016 Mar; 59(5):1818-29. PubMed ID: 26871940
[TBL] [Abstract][Full Text] [Related]
14. Molecular Dynamics Simulation Study of the Selective Inhibition of Coagulation Factor IXa over Factor Xa.
Yoon HJ; Kundu S; Wu S
Molecules; 2023 Oct; 28(19):. PubMed ID: 37836752
[TBL] [Abstract][Full Text] [Related]
15. New insights into how blood clots: implications for the use of APTT and PT as coagulation screening tests and in monitoring of anticoagulant therapy.
Bajaj SP; Joist JH
Semin Thromb Hemost; 1999; 25(4):407-18. PubMed ID: 10548073
[TBL] [Abstract][Full Text] [Related]
16. Factor IXa as a target for anticoagulation in thrombotic disorders and conditions.
Smiley DA; Becker RC
Drug Discov Today; 2014 Sep; 19(9):1445-53. PubMed ID: 24998782
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological evaluation of Isosteviol derivatives as FXa inhibitors.
Shi Y; Pan BW; Li WC; Wang Q; Wu Q; Pan M; Fu HZ
Bioorg Med Chem Lett; 2020 Jan; 30(2):126585. PubMed ID: 31859158
[TBL] [Abstract][Full Text] [Related]
18. Discovery of hydroxy pyrimidine Factor IXa inhibitors.
Jayne CL; Andreani T; Chan TY; Chelliah MV; Clasby MC; Dwyer M; Eagen KA; Fried S; Greenlee WJ; Guo Z; Hawes B; Hruza A; Ingram R; Keertikar KM; Neelamkavil S; Reichert P; Xia Y; Chackalamannil S
Bioorg Med Chem Lett; 2020 Aug; 30(15):127279. PubMed ID: 32527459
[TBL] [Abstract][Full Text] [Related]
19. A novel inhibitor of factor X activation from the salivary glands of the bed bug Cimex lectularius.
Valenzuela JG; Guimaraes JA; Ribeiro JM
Exp Parasitol; 1996 Jul; 83(2):184-90. PubMed ID: 8682187
[TBL] [Abstract][Full Text] [Related]
20. RNA aptamers as reversible antagonists of coagulation factor IXa.
Rusconi CP; Scardino E; Layzer J; Pitoc GA; Ortel TL; Monroe D; Sullenger BA
Nature; 2002 Sep; 419(6902):90-4. PubMed ID: 12214238
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]